The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- Headache (3%)
- Stomach pain (2%)
- Diarrhea (2%)
- Abnormal liver enzyme levels (2%)
Less Common Side Effects
- Stomach bloating
- Indigestion
- Back pain
- Joint pain
- Fatigue
- High blood pressure
- Rash
- Itching
- Hair loss
Note: Side effects listed were reported by adults who took 2.4 grams of mesalamine DR (Lialda) per day for maintenance of remission. Side effects might differ depending on dosage and age.
Lialda serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Kidney damage: urinating less often than usual; dry and itchy skin; muscle cramps; swelling in your feet, ankles, or hands
- Kidney stone: trouble urinating, bloody urine, fever, chills, back or side pain
- Liver problems: stomach bloating, right-sided stomach pain, yellowing of your skin or the whites of your eyes, dark urine
- Serious allergic reactions: hives, swelling of the lips or tongue, trouble breathing
- Serious skin reactions: hives, blisters, peeling skin, skin reddening, fever, sore throat, swollen lymph nodes
Source: DailyMed
The following Lialda side effects have also been reported
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
Less common
Bloody stools
bloody urine
blurred vision
chest tightness
chills
clay-colored stools
dark urine
difficulty with breathing
dizziness
full or bloated feeling
general feeling of discomfort or illness
headache
itching, skin rash
joint pain
loss of appetite
muscle aches and pains
nervousness
pain or tenderness around the eyes and cheekbones
pounding in the ears
pressure in the stomach
runny or stuffy nose
shivering
slow or fast heartbeat
stomach cramps
sweating
swelling of the stomach area
trouble sleeping
unpleasant breath odor
unusual tiredness or weakness
vomiting
vomiting of blood
yellow eyes or skin
Incidence not known
Black, tarry stools
blistering, peeling, or loosening of the skin
change in the ability to see colors, especially blue or yellow
chest discomfort
decreased frequency or amount of urine
greatly increased frequency of urination or amount of urine
hives or welts
hoarseness
inability to move the arms and legs
increased thirst
indigestion
large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or genitals
light-colored stools
lower back or side pain
muscle weakness, sudden and progressing
pain in the ankles or knees
painful or difficult urination
painful, red lumps under the skin, mostly on the legs
rapid breathing
red skin lesions, often with a purple center
red, irritated eyes
severe nausea or vomiting
sores, ulcers, or white spots in the mouth or on the lips
stomach tenderness
sudden numbness and weakness in the arms and legs
swelling of the feet or lower legs
swollen or painful glands
thickening of bronchial secretions
unusual bleeding or bruising
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
Less common
belching
continuing ringing or buzzing or other unexplained noise in the ears
difficulty with moving
dizziness or lightheadedness
excess air or gas in the stomach or bowels
feeling of constant movement of self or surroundings
hair loss or thinning of the hair
hearing loss
muscle stiffness
passing gas
sensation of spinning
stomach discomfort or upset
Incidence not known
Burning, numbness, tingling, or painful sensations
unsteadiness or awkwardness
weakness in the arms, hands, legs, or feet
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.




