Juvisync
Juvisync (sitagliptin / simvastatin) is a combination medication used for people with Type 2 diabetes who might also have high cholesterol. It's used along with diet and exercise to help lower blood sugar and "bad" cholesterol, which can help lower the risk of heart attack and stroke. This medication has been discontinued by the manufacturer and is no longer available in the United States.
What is Juvisync (sitagliptin / simvastatin)?
What is Juvisync (sitagliptin / simvastatin) used for?
Type 2 diabetes with:
- High cholesterol
- Risk of heart attack or stroke
Drug facts
Common questions about Juvisync (sitagliptin / simvastatin)
Juvisync (sitagliptin / simvastatin) is a combination of two medications. Sitagliptin is a medication that helps bring down blood sugar in people with Type 2 diabetes. It works by blocking dipeptidyl peptidase-4 (DPP-4), which is a protein that lowers the amount of insulin in the body. By stopping DPP-4, sitagliptin helps the body make more insulin so it can break down sugar for energy. This lowers blood sugar levels. Simvastatin is a statin that works by slowing the production of cholesterol in the body. It helps lower your low-density lipoprotein (LDL, or "bad" cholesterol) and triglyceride (fat) levels. This can help lower the risk of heart attack or stroke. Statins are often recommended in people with Type 2 diabetes, because they also tend to have high cholesterol levels. Both diabetes and high cholesterol can raise your risk of heart attack or stroke.
No, Juvisync (sitagliptin / simvastatin) has been discontinued as of 2013 and is no longer available in the United States.
The manufacturer (Merck) voluntarily discontinued Juvisync (sitagliptin / simvastatin) in 2013 for business reasons only. It wasn't taken off the market for safety concerns or lack of benefit.
Juvisync (sitagliptin / simvastatin) is a combination of two medications, sitagliptin and simvastatin, which are both still available and are sold separately. Sitagliptin is only available as brand-name Januvia. Simvastatin is available as both brand-name Zocor and generic. Keep in mind that there are many factors that your provider must consider when choosing a medication for Type 2 diabetes. Talk with your provider to determine which medications are best for your health conditions.
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Juvisync (sitagliptin / simvastatin) dosage
Typical dosage for Juvisync (sitagliptin / simvastatin)
Interactions between Juvisync (sitagliptin / simvastatin) and other drugs
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.
- Amprenavir
- Atazanavir
- Boceprevir
- Clarithromycin
- Cobicistat
- Cyclosporine
- Danazol
- Darunavir
- Erythromycin
- Fosamprenavir
- Gemfibrozil
- Idelalisib
- Indinavir
- Itraconazole
- Ketoconazole
- Letermovir
- Lopinavir
- Mibefradil
- Mifepristone
- Nefazodone
- Nelfinavir
- Paritaprevir
- Posaconazole
- Ritonavir
- Saquinavir
- Telaprevir
- Telithromycin
- Tipranavir
- Voriconazole
Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Acarbose
- Acenocoumarol
- Amiodarone
- Amlodipine
- Azithromycin
- Balofloxacin
- Bempedoic Acid
- Besifloxacin
- Bezafibrate
- Carbamazepine
- Ceritinib
- Chloroquine
- Chlorpropamide
- Ciprofibrate
- Ciprofloxacin
- Clofibrate
- Colchicine
- Conivaptan
- Dabigatran Etexilate
- Dalfopristin
- Daptomycin
- Darolutamide
- Delavirdine
- Diltiazem
- Dronedarone
- Duvelisib
- Eltrombopag
- Enasidenib
- Enoxacin
- Eslicarbazepine Acetate
- Fenofibrate
- Fenofibric Acid
- Fleroxacin
- Fluconazole
- Flumequine
- Fosnetupitant
- Fusidic Acid
- Gatifloxacin
- Gemifloxacin
- Glecaprevir
- Glimepiride
- Glipizide
- Glyburide
- Hydroxychloroquine
- Ivosidenib
- Lanreotide
- Larotrectinib
- Lefamulin
- Leflunomide
- Levamlodipine
- Levofloxacin
- Lomefloxacin
- Lomitapide
- Lorlatinib
- Lumacaftor
- Metformin
- Moxifloxacin
- Nadifloxacin
- Nateglinide
- Netupitant
- Niacin
- Norfloxacin
- Octreotide
- Ofloxacin
- Pasireotide
- Pazopanib
- Pazufloxacin
- Pefloxacin
- Pibrentasvir
- Prulifloxacin
- Quinupristin
- Ranolazine
- Repaglinide
- Risperidone
- Rufloxacin
- Simeprevir
- Sparfloxacin
- Tadalafil
- Teriflunomide
- Thioctic Acid
- Tolazamide
- Tolbutamide
- Tosufloxacin
- Verapamil
- Warfarin
Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Acebutolol
- Albiglutide
- Alitretinoin
- Atenolol
- Betaxolol
- Bisoprolol
- Bosentan
- Carteolol
- Carvedilol
- Celiprolol
- Cilostazol
- Clopidogrel
- Digoxin
- Efavirenz
- Esmolol
- Fosphenytoin
- Fostemsavir
- Interferon Beta
- Labetalol
- Levobunolol
- Levothyroxine
- Metipranolol
- Metoprolol
- Nadolol
- Nebivolol
- Oat Bran
- Oxcarbazepine
- Oxprenolol
- Pectin
- Penbutolol
- Phenytoin
- Pindolol
- Practolol
- Propranolol
- Rifampin
- Sotalol
- St John's Wort
- Ticagrelor
- Timolol
