Invega Sustenna, a brand name for paliperidone, is a long-acting injection. It's an atypical antipsychotic that helps treat schizophrenia or schizoaffective disorder in adults. The injection is given into the shoulder muscle or buttock by a trained healthcare professional. The first two starting doses are given one week apart. Then, the rest of the doses are given once a month. Side effects can include injection site reactions, headache, and sleepiness.
Schizophrenia in adults
Schizoaffective disorder in adults
Invega Sustenna (paliperidone) is an atypical antipsychotic. It's not exactly known how it works for schizophrenia and schizoaffective disorder.
Researchers think it balances out how much dopamine and serotonin is in your brain. These chemicals play a role in helping to control your thoughts, mood, and behaviors.
Source:Â DailyMed
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur:
More common
bladder pain
bloody or cloudy urine
body aches or pain
chills
deep or fast breathing with dizziness
difficult, burning, or painful urination
difficulty with breathing
difficulty with swallowing
ear congestion
frequent urge to urinate
headache
inability to sit still
irregular heartbeat
irritability
loss of balance control
loss of voice
lower back or side pain
mask-like face
need to keep moving
nervousness
numbness of the feet, hands, and around the mouth
restlessness
runny or stuffy nose
shaking
shuffling walk
slowed movements
slurred speech
stiffness of the arms and legs
tic-like (jerky) movements of the head, face, mouth, and neck
trembling and shaking of the fingers and hands
trouble with sleeping
twitching, twisting, uncontrolled repetitive movements of the tongue, lips, face, arms, or legs
unusual tiredness or weakness
Less common
Blurred vision
difficulty with speaking
dizziness
inability to move the eyes
increase in body movements
increased blinking or spasms of the eyelid
loss of balance control
muscle trembling, jerking, or stiffness
pounding in the ears
slow or fast heartbeat
sticking out of the tongue
uncontrolled movements, especially of the face, neck, and back
uncontrolled twisting movements of the neck, trunk, arms, or legs
unusual facial expressions
Incidence not known
Change in mental status
decrease in the amount and frequency of urination
difficulty speaking
large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or genitals
loss of bladder control
pale color of the skin
pinpoint red spots on the skin
puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
seizures
severe constipation
severe vomiting
stomach pain
swollen tongue
tightness in the chest
yellow eyes or skin
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
Less common
Back pain
difficulty with moving
increased weight
lack or loss of strength
muscle pains, cramps, or stiffness
nightmares
pain and swelling in the joints
pain in the arms or legs
tearing of the skin
toothache
upper abdominal or stomach pain
vomiting
Incidence not known
Sleepwalking
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
Maintenance doses are given once a month
Good option if you have trouble remembering to take your oral medication
Less side effects than typical antipsychotics
Might start to help with schizophrenia symptoms within the first week
Must go to the medical office to get the injections
Can cause pain, redness, and swelling where the medication is injected
Could take some time to find a dose that works best for you, since adjustments can only be made once a month
Not approved for people under 18
Set your appointments in your calendar for your Invega Sustenna (paliperidone) injections. The first two injections are a week apart, and then the rest of the injections are once a month. This helps make sure you remember to get your treatment on time.
Talk to your care team if you need to get your Invega Sustenna (paliperidone) injection early. They can work with you to reschedule. It depends on how much earlier you want to get your injection.
Call your care team if you forget or miss your appointment for your Invega Sustenna (paliperidone) injection. Your care team can help you reschedule. It depends on how much time has passed since you missed the injection.
Invega Sustenna (paliperidone) can make your blood pressure drop when you stand up. This can make you dizzy and make you fall. It's more likely to happen when you start the medication for the first time or when you switch to a higher dose. Make sure to stand up slowly. Tell your prescriber if you get too dizzy from the medication.
Invega Sustenna (paliperidone) can make you have strange, repetitive movements you can't control. This can look like face grimacing, lip smacking, sticking out your tongue, or swinging arm arms. These might be signs of tardive dyskinesia, which can become permanent. Let your care team know right away if this happens.
Drink lots of water and other liquids to stay hydrated. This is extra important if you're out in the sun, exercising hard, or going somewhere that's very hot. Invega Sustenna (paliperidone) might make it hard for your body to cool itself down. This can raise your risk of dehydration.
It's best not to drink alcohol while taking Invega Sustenna (paliperidone). Alcohol can sometimes make your schizophrenia problems worse. And it can make side effects from the medication worse. This can include feeling very sleepy and dizzy. Talk to your prescriber if you have questions about not drinking alcohol while taking this medication.
Tell your prescriber and pharmacist about all the medications you take and plan to take. Invega Sustenna (paliperidone) can interact with many medications. This includes some medications for seizure, high blood pressure, and the heart. Your care team can check that all your medications are safe to take together.
If you're pregnant or thinking about getting pregnant, talk to your prescriber. They can explain the risks and benefits of taking Invega Sustenna (paliperidone). Taking antipsychotics during late pregnancy might raise the risk that your newborn can have movement problems. They also might have withdrawal symptoms. But it's also important for you to keep getting help for your mental health while pregnant. Your prescriber can help you decide what's the best choice for you.
If you're trying to get pregnant, talk to your prescriber or gynecologist. Invega Sustenna (paliperidone) might make it harder for you to get pregnant.
Invega Sustenna (paliperidone) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Risk factors: Older adults with dementia-related psychosis
Older adults with dementia can sometimes have some symptoms of schizophrenia. They might see, hear, or believe things that aren't real. This is called dementia-related psychosis. Studies show that older adults with this problem taking antipsychotic medications like Invega Sustenna (paliperidone) have a higher risk of stroke or death. The cause of death was typically from heart problems or infections.
Because of this risk, Invega Sustenna (paliperidone) is not approved for older adults with dementia-related psychosis. Tell your prescriber if you have dementia before starting this medication. Caregivers should let the prescriber know if the person they care for has dementia.
Invega Sustenna (paliperidone) has been linked to a rare but serious problem called neuroleptic malignant syndrome (NMS). Stop taking this medication and get medical help as soon as you can if you have signs of NMS. Watch for signs like a very high fever, sweating a lot, stiff muscles, and problems thinking clearly.
Risk factors: History of heart problems or abnormal heart rhythms (arrhythmias) | Slow heart rate | Born with QT prolongation | Low potassium or magnesium levels | Taking other medications that can cause QT prolongation
Although rare, Invega Sustenna (paliperidone) can affect your heart rhythm. It can make the heart take longer to relax after each beat. This is called QT prolongation and it can be life-threatening.
Tell your prescriber about all your medical conditions. Also let your prescriber and pharmacist know about all the medications you take or plan to take. Certain medical conditions and medications can raise your risk of QT prolongation. Your care team can check that Invega Sustenna (paliperidone) is safe for you. For example, people born with QT prolongation or those who have arrhythmia shouldn't take this medication.
If you feel your chest pounding, have trouble breathing, have chest pain, or feel like you might faint while taking Invega Sustenna (paliperidone), call 911 right away. These can be signs of a problem with your heart rhythm.
Risk factors: Older adults | Female 65 years and older
Antipsychotics like Invega Sustenna (paliperidone) can cause movements you can't control. This is called tardive dyskinesia. It can look like face twitching or grimacing, mouth movements, and sticking out your tongue. Other examples include rocking back and forth or swinging your arms.
The risk for these movement problems, and that they'll become permanent, goes up if you take the medication for a long time or at a high dose. But it can also sometimes happen even at low doses or after you stop treatment. To help lower the risk, you'll be given the lowest dose for the shortest time needed to treat your symptoms.
Get medical help right away if you notice any unusual movements you can't control while taking Invega Sustenna (paliperidone).
Risk factors: Diabetes | High cholesterol
Some people taking Invega Sustenna (paliperidone) might have higher blood sugar. In rare cases, blood sugar levels can get dangerously high. Tell your prescriber if you or a family member has diabetes. You might need to check your blood sugar more often. Tell them if it stays higher than usual. Watch for signs like feeling very thirsty, hungry, or weak; urinating more often; or having fruity-smelling breath. These could be signs of very high blood sugar.
Antipsychotics like Invega Sustenna (paliperidone) might also make your cholesterol and triglycerides high. Get blood tests done when your prescriber tells you. This helps keep track of your cholesterol and makes sure it doesn't get too high.
In addition, some people might gain weight while taking Invega Sustenna (paliperidone). Try to eat balanced, nutritious meals and stay active to help stay healthy. If you're worried about your weight, talk to your prescriber or primary care provider.
Risk factors: Older adults | Low blood pressure | Dehydration | Heart problems | Taking blood pressure medications | Starting Invega Sustenna (paliperidone) for the first time
Invega Sustenna (paliperidone) can make your blood pressure drop when you stand up. This can make you feel dizzy and lightheaded, which can make you lose your balance. Although rare, some people have also fainted. These effects can lead to falls or accidental injuries.
The risk of these effects is higher for older adults. It also might be higher for people who are dehydrated or have certain heart problems.
Be sure to sit or stand up slowly, especially during the first few days after starting Invega Sustenna (paliperidone). If you feel dizzy, sit back down until you feel better. Talk to your care team if you still while taking Invega Sustenna (paliperidone). Call for medical help if you accidentally fall and get hurt.
Risk factors: History of low white blood cell counts | Taking other medications that lower white blood cell counts
Some people who took Invega Sustenna (paliperidone) had a drop in their white blood cell counts. White blood cells are important for fighting off germs. So when you have a low white blood cell count, it can put you at risk of getting infections.
People who already have a low white blood cell count might need blood tests often during the first few months of treatment. This helps the care team check that your blood cell count is okay. If it drops too much, you might need to stop taking Invega Sustenna (paliperidone).
Call your care team right away if you have any signs of infection while taking Invega Sustenna (paliperidone). Watch for signs like fever, chills, weakness, cough, trouble breathing, and sore throat.
Invega Sustenna (paliperidone) can raise your prolactin levels. When your prolactin levels are high, it can cause milky discharge from the nipple and larger breasts. You might also have irregular menstrual periods, sexual dysfunction, and problems with fertility. Your bones might also become weak if your prolactin levels stay high for a long time. Talk to your prescriber if you notice these symptoms while taking Invega Sustenna (paliperidone).
Risk factors: Age 65 years and older | Drinking alcohol | Taking other medications that can make you sleepy and have trouble thinking
Invega Sustenna (paliperidone) can make you very sleepy, which can raise your risk of falls. It can also make it hard to think, pay attention, and react quickly.
Your risk of these side effects is higher if you also take other medications that make you sleepy. Examples include benzodiazepines, muscle relaxants, and sleep medications.
These side effects can make driving or doing other things dangerous. Be sure you know how Invega Sustenna (paliperidone) affects you before doing anything that needs your full attention. Tell your prescriber if you get too sleepy and it's hard to go about your daily life.
Risk factors: History of seizures | Health conditions that make it easier to have a seizure
Invega Sustenna (paliperidone) might raise the risk of seizures in certain people. Tell your prescriber if you've had a seizure before or have a medical condition makes seizures more likely to happen. They can help you decide if Invega Sustenna (paliperidone) is right for you. Call for medical help if you have a seizure.
Some people taking antipsychotic medications like Invega Sustenna (paliperidone) might have trouble swallowing. If food or liquid accidentally get into your lungs, it can be dangerous. It can cause lead to breathing problems or pneumonia (a lung infection).
Be sure to chew your food well and swallow slowly, especially if your throat or neck area feels tight. Talk to your prescriber if you have any trouble swallowing.
Invega Sustenna (paliperidone) is given as an injection by a trained healthcare professional.
Your prescriber will decide what your dose will be based on how you respond to the medication. The typical dosing schedule is outlined below.
Schizophrenia
Day 1: 234 mg once into the shoulder muscle.
Day 8: 156 mg once into the shoulder muscle.
Maintenance dose: Starting 5 weeks after the first injection, the recommended maintenance dose is 117 mg once a month. But it can range between 39 mg and 234 mg per month, depending on your response. It's given into either the shoulder or buttock muscle.
Schizoaffective disorder
Day 1: 234 mg once into the shoulder muscle..
Day 8: 156 mg once into the shoulder muscle..
Maintenance dose: The typical maintenance dose ranges from 78 mg and 234 mg once a month, starting 5 weeks after the first injection. It's given into either the shoulder or buttock muscle.
Your dose might be different if you have kidney problems.
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.
Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
Allergy to paliperidone (Invega) or risperidone (Risperdal)
Schizophrenia in adults
Schizoaffective disorder in adults
Schizophrenia in adults
Bipolar 1 disorder in adults
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Bossie, C. A., et al. (2011). Onset of efficacy and tolerability following the initiation dosing of long-acting paliperidone palmitate: Post-hoc analyses of a randomized, double-blind clinical trial. BioMed Central Psychiatry.
Emsley, R., et al. (2013). The nature of relapse in schizophrenia. BioMed Central Psychiatry.
Janssen Pharmaceuticals, Inc. (2025). Invega Sustenna- paliperidone palmitate injection [package insert]. DailyMed.
MedlinePlus. (2023). Aspiration pneumonia.
MedlinePlus. (2024). Agitation.
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