Hympavzi
Hympavzi (marstacimab or marstacimab‑hncq) is a tissue factor pathway inhibitor (TFPI) antagonist used to help prevent or reduce bleeding in adults and children 6 years and older with hemophilia A or hemophilia B who don’t have inhibitors. The medication is given as a once‑weekly injection under the skin using a prefilled pen or syringe. Common side effects include injection‑site reactions, headache, and itching.
What is Hympavzi (marstacimab)?
What is Hympavzi (marstacimab) used for?
To prevent or reduce bleeds in people 6 years and older with:
- Hemophilia A without factor VIII inhibitors, or
- Hemophilia B without factor IX inhibitors
How Hympavzi (marstacimab) works
Hympavzi (marstacimab) is a tissue factor pathway inhibitor (TFPI) antagonist. It blocks a protein called TFPI, which normally slows down blood clotting.
By blocking TFPI, Hympavzi (marstacimab) helps your body make more thrombin, a protein that helps blood clot. This helps your blood clot more effectively and can reduce bleeding episodes in people with hemophilia.
Drug facts
| Common Brands | Hympavzi |
|---|---|
| Drug Class | TFPI antagonist |
| Controlled Substance Classification | Not a controlled medication |
| Generic Status | No lower-cost generic available |
| Availability | Prescription only |
Side effects of Hympavzi (marstacimab)
The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- Injection‑site reactions (9%)
- Headache (7%)
- Itching (3%)
Hympavzi (marstacimab) serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Blood clots: swelling or pain in the arms or legs, redness or skin color changes in the arms or legs, shortness of breath, chest or upper‑back pain, fast heartbeat, coughing up blood, fainting, headache, facial droop or numbness, eye pain or swelling, trouble seeing
- Severe allergic reaction: swelling of the face or throat, trouble breathing, wheezing, dizziness or fainting, fast or pounding heartbeat, sweating
The following Hympavzi (marstacimab) side effects have also been reported
Side effects that you should report to your care team as soon as possible:
- Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
- Blood clot—pain, swelling, or warmth in the leg, shortness of breath, chest pain
Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):
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Pros and cons of Hympavzi (marstacimab)
Pros
- Injected once a week
- Given under the skin instead of into a vein
- Helps reduce bleeding events in both hemophilia A and hemophilia B
Cons
- Can raise the risk of dangerous blood clots
- Not studied or approved for people with inhibitors
- Not safe in pregnancy
Pharmacist tips for Hympavzi (marstacimab)
- Learn how to use Hympavzi (marstacimab) from a healthcare professional before injecting it at home. Read the Instructions for Use and ask your care team if you have questions.
- If you miss a dose of Hympavzi (marstacimab), inject it as soon as you remember. Follow the missed‑dose directions from your package insert or prescriber so you stay protected between doses.
- Don’t use Hympavzi (marstacimab) to treat a bleeding event. Ask your care team what treatment to use if you have a bleed.
- Watch for signs of a blood clot while taking Hympavzi (marstacimab). Get medical help right away if you have leg swelling, chest pain, shortness of breath, vision changes, or sudden weakness.
- Tell your care team if you have surgery planned while taking Hympavzi (marstacimab). Your treatment might need to be changed before the procedure.
- If you become very sick or have a serious injury while taking Hympavzi (marstacimab), contact your care team. They might have you pause treatment until you recover.
- Pregnancy: Hympavzi (marstacimab) might harm an unborn baby, so call your care team right away if you become pregnant. If you can get pregnant, use reliable birth control during treatment and for 2 months after your last dose.
- Breastfeeding: Talk with your care team before breastfeeding while taking Hympavzi (marstacimab). It’s not known if the medication passes into breast milk.
- Storage: Keep Hympavzi (marstacimab) in the refrigerator in its original carton. You can keep it at room temperature one time for up to 7 days, but don't put it back in the refrigerator afterward.
How to inject Hympavzi (marstacimab):
- Before injecting, let it sit at room temperature for 15 to 30 minutes.
- Wash your hands to lower the risk of infection and clean the skin with an alcohol swab or soap and water. Let it air dry.
- Choose an injection site on your stomach (2 inches away from your belly button) or front thigh. If someone is helping you, they can also inject into the back of the upper arm (prefilled syringe only) or buttocks (prefilled pen only).
- Don't inject into skin that's tender, red, or hard, and make sure to rotate the injection sites to reduce irritation.
- If using the prefilled syringe: Insert the uncapped needle at a 45° angle into your skin and push down the plunger all the way down.
- If using the prefilled pen: Hold the pen at a 90° angle against your skin and push firmly until you hear a click; continue pushing for 5 seconds after you hear the second click.
- Throw away the used pen or syringe in a sharps container right after use.
Risks and warnings for Hympavzi (marstacimab)
Hympavzi (marstacimab) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Blood clots
- Risk factors: Currently have health conditions that raise your risk for blood clots | History of clotting problems
Hympavzi (marstacimab) helps your body form blood clots to prevent bleeding episodes. While this is helpful for treating hemophilia, it can also increase your risk of serious blood clots. Your risk might be higher if you already have certain medical conditions or a history of blood clots.
Tell your care team right away if you have symptoms like leg pain or swelling, chest pain, or shortness of breath. If a blood clot is suspected, your care team might have you stop the medication and start treatment for the clot.
Allergic reactions
Allergic reactions can happen with Hympavzi (marstacimab). Mild reactions may include rash, itching, or hives. Rarely, serious allergic reactions can occur and may cause swelling of your face, lips, or tongue, trouble breathing, dizziness, fainting, or a fast heartbeat. Stop taking this medication and get emergency medical help right away if you have symptoms of a severe allergic reaction.
Harm to unborn babies
Hympavzi (marstacimab) might harm an unborn baby based on how it works. There isn’t enough information from people who are pregnant to know the exact risks, so talk with your prescriber if you’re pregnant or planning to become pregnant. They can help you weigh the benefits and risks of treatment.
If you can become pregnant, you’ll need a pregnancy test before starting Hympavzi (marstacimab). Use reliable birth control during treatment and for 2 months after your last dose. If you become pregnant while taking this medication, contact your care team right away.
Hympavzi (marstacimab) dosage
Carton| Dosage | Quantity | Price as low as | Price per unit |
|---|---|---|---|
| 1 prefilled pen of 150mg/ml | 4 cartons | $60,520.81 | $15,130.20 |
Typical dosage for Hympavzi (marstacimab)
Adults and children 12 years and older: The typical dose starts with a one‑time loading dose of 300 mg (given as two 150 mg injections under the skin) on the same day. Then one week later, 150 mg once a week starting on the same day each week.
Children 6 years to less than 12 years old: The typical dose starts with a one‑time loading dose of 150 mg (given as two 75 mg injections under the skin) on the same day. Then one week later, 75 mg once a week starting on the same day each week.
The dose might differ if your child weighs more than 55 lbs.
How much does Hympavzi (marstacimab) cost?
$60,520.81
What are alternatives to Hympavzi (marstacimab)?
To prevent or reduce bleeds in people 6 years and older with:
Hympavzi (marstacimab) images
