topotecan

Hycamtin (topotecan) is only FDA-approved to treat small cell lung cancer. But topotecan injection is approved to treat certain types of ovarian cancer and cervical cancer, in addition to small cell lung cancer. For small cell lung cancer, the dosing is different between oral and IV forms of the medication. While you’ll typically receive topotecan injection in a clinic or infusion center, Hycamtin (topotecan) can be taken at home. But be aware that Hycamtin (topotecan) needs to be refrigerated, so you'll need to properly and safely store this medication.

There are many ways you can lower your chances of developing an infection while you’re receiving Hycamtin (topotecan). For example, wash your hands often with soap, especially before eating, after using the bathroom, or after touching things like door knobs. If you can, avoid crowded places and people who are sick. But if you need to be around crowds, it’s best to wear a mask. To avoid food-borne illnesses, make sure to wash raw fruits and vegetables before eating, and cook foods thoroughly. It’s important to follow these tips during Hycamtin (topotecan) treatment because the medication weakens your immune system, and makes you more likely to develop a serious infection. Let your provider know right away if you have any signs of an infection, such as fever, tiredness, chills.

Hycamtin (topotecan) can cause hair loss and hair thinning because it damages your hair follicles. But not everyone will experience this side effect. According to clinical studies, 10-20% of people who took Hycamtin (topotecan) reported hair loss, but most of the time it was mild. For people who did experience hair loss, it typically starts 3 to 4 weeks after the first dose. This side effect is usually temporary and hair typically grows back after you’re done with the treatment. If you’re concerned about hair loss from Hycamtin (topotecan), talk with your provider about how to minimize this side effect. They might recommend that you try a cooling cap, or give you tips on proper hair care during chemotherapy.

If you’ve kidney problems, you might be at higher risk for side effects from Hycamtin (topotecan). Typically, the kidneys help get rid of Hycamtin (topotecan) from the body through urine. But if you have kidney problems, your body will have a hard time getting rid of the medication. This can lead to higher levels of the medication in your body and higher risk of side effects, such as risk of infection, nausea, vomiting, and diarrhea. Let your provider know if you have problems with your kidneys, as you’ll need to be monitored more closely and might need a lower dose of Hycamtin (topotecan).

Avoid breastfeeding while receiving Hycamtin (topotecan) and for one week after the last dose. We don’t know if it can pass into human breast milk. But if it does, the medication has a risk of causing serious harm to nursing babies. Talk to your provider if you have any questions about other ways to feed your baby while receiving Hycamtin (topotecan).