Hemgenix

Hemgenix (etranacogene dezaparvovec) can cause infusion reactions, such as rash, headaches, belly pain, lightheadedness, shivering, and flushing. Serious reactions like anaphylaxis or closing of the throat are possible as well. Your provider will watch for these reactions during your infusion and for at least 3 hours after you've received Hemgenix (etranacogene dezaparvovec). If you experience any reaction to Hemgenix (etranacogene dezaparvovec) during treatment, tell your provider right away so they can slow or stop your infusion until your symptoms go away. If your symptoms worsen, your provider might give you steroids or antihistamines for symptom relief.

Hemgenix (etranacogene dezaparvovec) can sometimes cause liver damage. This is most common in the first 3 or 4 months after the infusion, but it can happen later and last up to 2 years or more. You’ll need to get weekly blood tests done for at least the first 3 months after receiving Hemgenix (etranacogene dezaparvovec). This is so your provider can check your liver health. If you experience signs and symptoms of liver damage, such as upper right stomach pain, yellowing of the skin or whites of the eyes, or dark urine, talk with your provider immediately.

Based on the way Hemgenix (etranacogene dezaparvovec) works, there's a possible risk of developing liver cancer after treatment. Your risk might be higher if you have a history of liver problems, are older in age, or have a history of long-term alcohol use. For your safety, your provider might order ultrasound screenings and blood tests every year for at least 5 years after treatment to check for cancer. Speak with your provider if you have concerns about the risk of liver cancer. Let your provider know right away if you have symptoms of liver cancer, such as swelling in the belly, yellowing of the skin or whites of the eyes, or confusion.