The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
Less Common Side Effects
- Dizziness
- Vomiting
Guaifenesin/Codeine serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Allergic reactions: trouble breathing, hives, swelling of your face, lips, tongue, or throat
- Dangerously slow breathing: trouble breathing; bluish-colored lips, fingers, or toes
- Accidentally taking too much (overdose): not responding to sound or touch, slowed breathing, extreme sleepiness, slow heartbeat, cold or clammy skin
Source: DailyMed
The following Guaifenesin/Codeine side effects have also been reported
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Although serious side effects occur rarely when this medicine is taken as recommended, they may be more likely to occur if: too much medicine is taken, it is taken in large doses, or it is taken for a long period of time.
Get emergency help immediately if any of the following symptoms of overdose occur:
For narcotic antitussive (codeine, dihydrocodeine, hydrocodone, or hydromorphone)-containing
Cold, clammy skin
confusion (severe)
convulsions (seizures)
drowsiness or dizziness (severe)
nervousness or restlessness (severe)
pinpoint pupils of eyes
slow heartbeat
slow or troubled breathing
If you are a nursing mother and you notice any of the following symptoms of overdose in your baby, get emergency help immediately:
Difficulty breathing
difficulty nursing
increased sleepiness (more than usual)
limpness
For acetaminophen-containing
increased sweating
loss of appetite
nausea or vomiting
stomach cramps or pain
swelling or tenderness in the upper abdomen or stomach area
For salicylate-containing
Any loss of hearing
bloody urine
confusion
convulsions (seizures)
dizziness or lightheadedness
drowsiness (severe)
excitement or nervousness (severe)
fast or deep breathing
hallucinations (seeing, hearing, or feeling things that are not there)
increased sweating
nausea or vomiting (severe or continuing)
shortness of breath or troubled breathing (for salicylamide only)
stomach pain (severe or continuing)
uncontrollable flapping movements of the hands, especially in elderly patients
unusual thirst
vision problems
For decongestant-containing
Fast, pounding, or irregular heartbeat
headache (continuing and severe)
nausea or vomiting (severe)
nervousness or restlessness (severe)
shortness of breath or troubled breathing (severe or continuing)
Check with your doctor as soon as possible if any of the following side effects occur:
For antihistamine- or anticholinergic-containing
Clumsiness or unsteadiness
convulsions (seizures
drowsiness (severe)
dryness of mouth, nose, or throat (severe)
flushing or redness of face
hallucinations (seeing, hearing, or feeling things that are not there)
restlessness (severe)
shortness of breath or troubled breathing
slow or fast heartbeat
For iodine-containing
Headache (continuing)
increased watering of mouth
loss of appetite
metallic taste
skin rash, hives, or redness
swelling of face, lips, or eyelids
For acetaminophen-containing
Unexplained sore throat and fever
unusual tiredness or weakness
yellow eyes or skin
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
decreased sweating
difficult or painful urination
dizziness or lightheadedness
drowsiness
dryness of mouth, nose, or throat
false sense of well-being
increased sensitivity of skin to sun
nausea or vomiting
nightmares
stomach pain
thickening of mucus
trouble in sleeping
unusual excitement, nervousness, restlessness, or irritability
unusual tiredness or weakness
Not all of the side effects listed above have been reported for each of these medicines, but they have been reported for at least one of them. There are some similarities among these combination medicines, so many of the above side effects may occur with any of these medicines.
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

