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Fosamax Plus D

Fosamax Plus D Side Effects

Cydnee Ng, PharmDMichelle Nguyen, PharmD
Reviewed by Cydnee Ng, PharmD, Michelle Nguyen, PharmD
Last reviewed on December 19, 2024

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Stomach pain (4%)
  • Indigestion (3%)
  • Bone, muscle, or joint pain (3%)
  • Nausea (2%)
  • Acid reflux (2%)

Less Common Side Effects

  • Bloating
  • Constipation
  • Passing gas

Note: Side effects were reported in postmenopausal women who were taking 70 mg of alendronate (Fosamax) once weekly.

Fosamax Plus D serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Stomach or esophagus irritation: trouble swallowing, new pain with swallowing, pain around the middle of your chest, new or worsening heartburn
  • Severe pain in the bone, muscle, or joint
  • New fracture: dull or aching pain in your thigh or groin

Source: DailyMed

The following Fosamax Plus D side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Less common

Chest pain, discomfort, or burning

difficulty with swallowing

heartburn

muscle or bone pain

pain with swallowing

vomiting blood

Rare

Abdominal or stomach cramps

blistering, peeling, or loosening of the skin

bloating or swelling of the face, arms, hands, lower legs, or feet

chills

confusion

convulsions

cough

diarrhea

difficulty with breathing

fever

irregular heartbeats

itching

joint pain

large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs

mood or mental changes

muscle cramps in the hands, arms, feet, legs, or face

numbness and tingling around the mouth, fingertips, or feet

rapid weight gain

red skin lesions, often with a purple center

red, irritated eyes

shortness of breath

sore throat

sores, ulcers, or white spots in the mouth or on the lips

swelling of the neck

tremor

unusual tiredness or weakness

unusual weight gain or loss

vomiting

Incidence not known

Burning upper abdominal or stomach pain

difficulty with moving

heavy jaw feeling

loosening of a tooth

loss of appetite

muscle aching or cramping

muscle pains or stiffness

pain or burning in the throat

pain, swelling, or numbness in the mouth or jaw

severe bone, joint, or muscle pain

stomach bloating, burning, cramping, or pain

swollen joints

weight loss

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

Acid or sour stomach

belching

constipation

excess air or gas in the stomach or intestines

full feeling

headache

indigestion

passing gas

pressure in the stomach

stomach discomfort, upset, or pain

swelling of the abdominal or stomach area

Rare

Blurred vision or other change in vision

decreased vision

eye pain

eye redness

eye tenderness

flushing or redness of the skin

increased tearing

rash

redness of the eye

sensitivity of the eye to light

severe eye pain

tearing

unusually warm skin

Incidence not known

Dizziness or lightheadedness

feeling of constant movement of self or surroundings

general feeling of discomfort or illness

hair loss

hives or welts

lack or loss of strength

sensation of spinning

thinning of the hair

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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Why trust our experts?

Cydnee Ng, PharmD
Reviewed by:
Cydnee Ng, PharmD
Cydnee Ng, PharmD, is a drug information pharmacist at GoodRx, where she lends her expertise to providing reader-friendly, accessible content about medications. She holds her pharmacist license in California.
Michelle Nguyen, PharmD, has been a clinical pharmacist for 6 years (and counting). She has a diverse skill set within managed care pharmacy, specifically in the settings of a medical group, pharmacy benefit manager (PBM), and health plan.

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