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Fondaparinux

Fondaparinux Side Effects

Robert Chad Hakim, PharmD, BCCCPKristianne Hannemann, PharmD
Reviewed by Robert Chad Hakim, PharmD, BCCCP, Kristianne Hannemann, PharmD
Last reviewed on January 11, 2024

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Bleeding
  • Irritation around the injection site (e.g., bleeding, rash, itching)

Less Common Side Effects

  • Bruising
  • Anemia (low red blood cell count)
  • Dizziness
  • Low blood pressure
  • Confusion

Fondaparinux serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Severe bleeding: feeling faint, lightheaded, or dizzy; vomiting blood; bloody or dark-colored stools; severe stomach pain or discomfort
  • Blood clots due to stopping Fondaparinux too soon: in leg or arm (e.g., swelling or redness in arms or legs, skin that's warm to touch); in lungs (e.g., trouble breathing, chest pain, cough, irregular heartbeat)
  • Serious allergic reaction: rash; trouble breathing; swelling of the lips, tongue, or face; vomiting; chills; fever

Source: DailyMed

The following Fondaparinux side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Pale skin

troubled breathing with exertion

unusual bleeding or bruising

unusual tiredness or weakness

Less common

Black, tarry stools

bladder pain

bleeding gums

blood in the urine or stools

blurred vision

chest pain

chills

collection of blood under the skin

confusion

convulsions

cough

decreased or cloudy urine

deep, dark purple bruise

difficult, burning, or painful urination

dizziness

dry mouth

fainting or lightheadedness when getting up from a lying or sitting position

fever

frequent urge to urinate

increased thirst

irregular heartbeat

itching, pain, redness, or swelling at the injection site

loss of appetite

lower back or side pain

muscle pain or cramps

nausea or vomiting

numbness or tingling in the hands, feet, or lips

pinpoint red spots on the skin

red, tender, or oozing skin at incision

shortness of breath

sore throat

sores, ulcers, or white spots on the lips or in the mouth

sudden sweating

Incidence not known

Back pain

bowel or bladder dysfunction

difficulty with swallowing

fast heartbeat

hives, itching, or skin rash

large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs

leg weakness

numbness

paralysis

puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue

tightness in the chest

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

Abdominal or stomach pain or swelling

bruising or purple areas on the skin

coughing up blood

decreased alertness

headache

joint pain or swelling

nosebleeds

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Difficulty having a bowel movement

swelling

trouble sleeping

Less common

Acid or sour stomach

belching

diarrhea

heartburn

indigestion

pain

skin blisters

stomach discomfort, upset, or pain

tightness in the chest

unusual changes to site of surgery

wound drainage, increased

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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Why trust our experts?

Robert Chad Hakim, PharmD, BCCCP, started his full-time career as a clinical pharmacist at UCLA Health in the general medicine, general cardiology, and ICU units after completing residency in 2016. He also was the preceptor for the general medicine rotation from 2017 to 2021, which was a required rotation for all pharmacy residents.
Kristianne Hannemann, PharmD, is a licensed pharmacist in California. She has been a retail pharmacy manager and staff pharmacist for over 7 years and has contributed drug information content to different health companies.

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