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Heparin Sodium

Heparin Sodium Side Effects

Robert Chad Hakim, PharmD, BCCCPKristianne Hannemann, PharmD
Reviewed by Robert Chad Hakim, PharmD, BCCCP, Kristianne Hannemann, PharmD
Last reviewed on July 26, 2023

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

The side effects from [[EDITOR|DRUG_DISPLAY_NAME]] that you experience will depend on how you receive the medication (through the vein or under the skin) and the dose.

  • Anemia (low red blood cells; 5%)
  • Bleeding (4%)
  • Fever (4%)
  • Swelling in arms or legs (2-4%)
  • Bruising (3%)
  • Nausea (2%)
  • Blood in urine (2%)

Heparin Sodium serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Severe bleeding: feeling faint, lightheadedness, dizziness, vomiting blood, bloody or dark-colored stools, severe stomach pain or discomfort
  • Heparin-induced thrombocytopenia (HIT) or heparin-induced thrombocytopenia with thrombosis (HITT): skin changes or bruising, shortness of breath, chest pain or tightness, trouble speaking, numbness on one side of your body, vision problems
  • Serious allergic reaction: rash; trouble breathing; swelling of the lips, tongue, or face; vomiting; chills; fever
  • Blood clots due to stopping Heparin Sodium too soon: leg or arm (e.g., swelling or redness in arms or legs, skin that's warm to touch); lungs (e.g., trouble breathing, chest pain, cough, irregular heartbeat)

Source: DailyMed

The following Heparin Sodium side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

Less common

Abdominal or stomach pain or swelling

back pain or backaches

bleeding from the gums when brushing teeth

blood in the urine

constipation

coughing up blood

dizziness

headaches, severe or continuing

heavy bleeding or oozing from cuts or wounds

joint pain, stiffness, or swelling

menstrual bleeding, unexpected or unusually heavy

unexplained bruising or purplish areas on the skin

unexplained nosebleeds

vomiting of blood or material that looks like coffee grounds

Rare

Blood under the skin (blood blister) at the place of injection

chest pain

chills or fever

fast or irregular breathing

irritation, pain, redness, or ulcers at the place of injection

itching and burning feeling, especially on the bottom of the feet

nausea or vomiting

numbness or tingling in the hands or feet

pain, coldness, or blue color of the skin on the arms or legs

peeling of the skin

puffiness or swelling of the eyelids or around the eyes

shortness of breath

skin color change, especially near the place of injection or in the fingers, toes, arms, or legs

skin rash, hives, or itching

tearing of the eyes

tightness in the chest

trouble with breathing

wheezing

After you stop using this medicine, it may still produce some side effects that need attention. During this period of time, check with your doctor immediately if you notice the following side effects:

Black, tarry stools

bleeding gums

blood in the urine or stools

pain in the chest, groin, or legs, especially calves of legs

pinpoint red spots on the skin

severe headaches of sudden onset

sudden loss of coordination

sudden shortness of breath for no apparent reason

sudden slurred speech

sudden vision changes

unusual bleeding or bruising

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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