7 Statin Alternatives You Can Take to Help Lower Your Cholesterol
Statins may not be safe and effective for all people with high cholesterol. Some statin alternatives, like fibrates, may be able to help. Review your options here.
fenofibrate
Used for High Cholesterol, High Triglycerides
Used for High Cholesterol, High Triglycerides
Fenofibrate (also known as fenofibric acid) is used as an add-on medication to diet to treat high triglycerides and high cholesterol. Common side effects include liver problems, breathing problems, and stomach pain. Fenofibrate includes a warning about avoiding statin medications because of the risk of muscle damage, and also because it doesn't add any extra benefit in reducing the risk of heart problems compared to taking a statin alone. Fenofibrate is available in many brand names (e.g., Antara, Tricor, Trilipix), generics, and dosage forms (e.g., micronized capsules, delayed-release capsules, tablets).
What is Fenofibrate?
What is Fenofibrate used for?
- Treatment of high triglycerides - add-on to diet
- Treatment of high "bad" cholesterol (LDL), with or without high triglycerides and low "good" cholesterol (HDL) - add-on to diet
How Fenofibrate works
Fenofibrate is a fibrate. It works by breaking down lipids (fatty substances) in your blood, such as "bad" cholesterol (low-density lipoprotein or LDL) and triglycerides. This lowers the amount of lipids that can clog your arteries and helps blood flow more smoothly to different parts of your body.
Fenofibrate also helps make more "good" cholesterol (high-density lipoprotein or HDL) in your body. Having more HDL can lower your risk for heart problems or stroke.
When does Fenofibrate start working?Time passed since treatment started:
Drug facts
| Common Brands | Fenoglide, Trilipix, Antara, Tricor, Lipofen |
|---|---|
| Drug Class | Fibrate |
| Controlled Substance Classification | Not a controlled medication |
| Generic Status | Lower-cost generic available |
| Availability | Prescription only |
Side effects of Fenofibrate
The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- Liver damage (8%)
- Lung problems (6%)
- Stomach pain (5%)
Less Common Side Effects
- Back pain
- Headache
- Stuffy nose
- Nausea
- Constipation
- Rash
Fenofibrate serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Serious allergic and skin reactions: sore throat, fever, fatigue, rash, hives, painful blisters, skin reddening, skin peeling, swollen lymph nodes
- Liver damage: swelling of your stomach, stomach pain, nausea, vomiting, yellowing of your skin or the whites of your eyes, confusion
- Severe muscle pain: fever, tired, dark-colored (brown or red color) urine, muscle pain, cramps, or weakness
- Blood clots in lungs or legs: chest pain, difficulty breathing, swelling or warmth in your legs, leg muscles that are tender to the touch
When do Fenofibrate possible side effects begin and end?
Time passed since treatment started:
H
D
W
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Possible effect on the kidneys
Risk of liver damage
Risk of severe muscle damage
Seek immediate medical care if you experience this side effect.
If a line continues to the right, you'll likely keep experiencing this side effect once it starts.
More on Fenofibrate side effects
The following Fenofibrate side effects have also been reported
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
Rare
Chronic indigestion
dark urine
muscle cramps, spasms, stiffness, swelling, or weakness
troubled breathing
unusual bleeding or bruising
unusual tiredness or weakness
yellow eyes or skin
Incidence not known
Agitation
bloody urine
decreased frequency or amount of urine
difficulty in moving
fast heartbeat
general tiredness and weakness
increased blood pressure
increased thirst
indigestion
joint pain or swelling
light-colored stools
loss of appetite
lower back or side pain
pains in the stomach, side, or abdomen, possibly radiating to the back
pale skin
swelling of the face, fingers, or lower legs
troubled breathing with exertion
upper right abdominal or stomach pain
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Incidence not known
Lack or loss of strength
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
Get your GoodRx coupon
$95.28
GoodRx discount
$16.02
Pros and cons of Fenofibrate
Pros
- Lowers triglycerides and LDL ("bad" cholesterol) while raising HDL ("good" cholesterol)
- Only needs to be taken once daily
- Some brands can be taken with or without food
- Some brands available as lower-cost generics
Cons
- Need to take it alongside a low-fat diet; doesn't work well on its own
- Can cause muscle damage, especially if taken with a statin
- Not recommended during pregnancy or breastfeeding
- Can't take if you have liver, severe kidney, or gallbladder problems
Pharmacist tips for Fenofibrate
- Make sure to mark your appointment and scheduled lab work dates on your calendar. Typically, you'll need to get lab work done every 1 to 2 months to see how well fenofibrate is working for you.
- Swallow fenofibrate pills whole. Don't chew, break, or open the pills since this can damage the medication and cause you to take the wrong dose.
- Make sure to check with your provider or pharmacist if you should take fenofibrate with or without food, since it depends on which brand you're taking. You'll need to take some forms with food (e.g., Fenoglide, Lipofen), while you can take other forms with or without food (e.g., Antara, Tricor).
- Fenofibrate can change the way other medications work. Make sure to tell your provider about all the medications you're taking before starting fenofibrate. Don't start any new medications while taking fenofibrate without talking to your provider or pharmacist first.
- If you're taking blood thinners like warfarin (Coumadin), you should get your INR checked more frequently when you first start fenofibrate because it can raise your INR level and bleeding risk. If you have any signs or symptoms of bleeding (e.g., feeling faint, dizziness, bleeding that is difficult to stop, blood in your urine or stool), seek medical attention right away.
- If you're also taking a bile acid sequestrant for your high cholesterol, make sure to take fenofibrate at least 1 hour before or 4 to 6 hours after the bile acid sequestrant. Bile acid sequestrants can affect how well fenofibrate works.
- Fenofibrate works best when combined with a healthy and balanced diet that's low in fat and a regular exercise routine. Ask your healthcare provider for more recommendations on how to manage your cholesterol and triglyceride levels through lifestyle changes.
Risks and warnings for Fenofibrate
Fenofibrate can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Liver damage
- Risk factors: Taking higher doses of fenofibrate
Fenofibrate can cause serious liver damage that can lead to liver failure and even death. Liver damage can happen anytime during treatment, but it might go away after you stop this medication. You'll need to get your blood drawn before starting fenofibrate and during treatment to make sure your liver is healthy. If there are concerning lab results or if you have symptoms of liver damage, you might need to stop using fenofibrate to prevent further liver damage. What's more, you can't use this medication if you already have liver problems. Get medical attention right away if you notice symptoms of liver problems, such as swelling of your stomach, stomach pain, nausea, vomiting, yellowing of your skin or the whites of your eyes, stool changes (black, tarry, or bloody stools), or confusion.
Muscle damage (myopathy and rhabdomyolysis)
- Risk factors: Older adults | Kidney failure | Diabetes | Low thyroid hormones (hypothyroidism) | Taking other medications that can cause muscle damage
Fenofibrate can raise the risk of muscle damage. If muscle damage is severe, it can lead to muscle breakdown (rhabdomyolysis), which can negatively affect your other organs. Your risk is higher if you're taking other medications that can cause muscle damage, such as statins, or if you have certain medical conditions, such as diabetes. Before starting fenofibrate, ask your provider if you're taking any other medications that might put you at risk for muscle damage. Seek medical attention right away if you develop fever, sudden muscle pain, cramps, weakness, or dark red or brown-colored urine.
Possible effect on the kidneys
- Risk factors: Age 65 years and older | Diabetes | Kidney problems
During clinical studies, some people taking fenofibrate have had higher levels of a protein in the blood called creatinine. This lab result suggests possible kidney damage, but keep in mind that it's unclear whether the medication actually harms the kidney or affects kidney function. To be safe, your provider might start you at a lower dose of fenofibrate and check your kidney function through blood tests. Your risk might be higher if you're 65 years and older, if you have diabetes, or if you have kidney problems. Let your provider know if you notice any changes in urination or dark-colored urine, as these can be signs of kidney problems.
Allergic reactions
Allergic reactions to fenofibrate are possible. These reactions can be life-threatening and can include mouth or facial swelling and anaphylaxis (closing of the throat). If you notice hives, swelling of your lips or tongue, or difficulty breathing after using fenofibrate, stop using it and seek medical attention right away.
Although rare, it's also possible for people who take fenofibrate to have severe and potentially fatal skin reactions. These reactions include Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and drug reaction with eosinophilia and systemic symptoms (DRESS)). The reactions can occur days to weeks after starting fenofibrate. Seek medical attention right away if you develop a fever, blistering rash, or swollen lymph nodes.
Gallstones
Fenofibrate can raise your risk of gallstones. For this reason, you can't use fenofibrate if you have gallbladder problems. Let your provider know right away if you experience stomach pain, back pain, nausea, or vomiting so you can be tested for gallstones.
Pancreatitis
Rarely, some people taking fenofibrate have developed inflammation in the pancreas (called pancreatitis). It's possible that this pancreas problem is due to having high triglyceride levels despite taking fenofibrate, the medication itself, or some other cause. Your provider can measure blood levels of certain proteins made by your pancreas and do imaging of your pancreas to check for this problem. Contact your provider if you develop sudden stomach pain, nausea, vomiting, or fluid buildup in your stomach area. These can be signs of problems in the pancreas.
Blood clots
Fenofibrate might raise your risk for blood clots in your lung (pulmonary embolism, PE) or leg (deep vein thrombosis, DVT). If you have chest pain, difficulty breathing, swelling in your leg, or warm skin that's tender to the touch, get medical help right away.
Fenofibrate dosage
The average cost for 30 tablets of 160mg of Fenofibrate is $16.02 with a free GoodRx coupon. This is 83.19% off the average retail price of $95.28.
Typical dosage for Fenofibrate
Your dose depends on what condition you’re using fenofibrate for. It also depends on what formulation of fenofibrate you're using. Your dose might differ if you have kidney problems.
Capsules
- Antara (micronized fenofibrate): The typical dose is 43 mg to 130 mg by mouth once per day.
- Generic micronized fenofibrate capsule: The typical dose is 67 mg to 200 mg by mouth once per day.
- Lipofen (fenofibrate): The typical dose is 50 mg to 150 mg by mouth once per day.
- Trilipix (fenofibric acid) and generic delayed-release fenofibric acid capsule: The typical dose is 45 mg to 135 mg by mouth once per day.
Tablets
- Fenoglide (fenofibrate): The typical dose is 40 mg to 120 mg by mouth once per day.
- Tricor (fenofibrate): The typical dose is 48 mg to 145 mg by mouth once per day.
More on Fenofibrate dosage
Interactions between Fenofibrate and other drugs
Fenofibrate may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Fenofibrate. Please note that only the generic name of each medication is listed below.
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.
- Ciprofibrate
Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Acenocoumarol
- Anisindione
- Atorvastatin
- Colchicine
- Dicumarol
- Fluvastatin
- Lovastatin
- Phenprocoumon
- Pitavastatin
- Pravastatin
- Rosuvastatin
- Simvastatin
- Warfarin
Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Colestipol
- Cyclosporine
- Ezetimibe
- Rosiglitazone
How much does Fenofibrate cost?
To access savings, use a GoodRx coupon and pay just a fraction of the retail price.
Fenofibrate contraindications
Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Fenofibrate will not be safe for you to take.
- Severe kidney disease or on dialysis
- Liver disease
- Gallbladder disease
- Nusing mothers
What are alternatives to Fenofibrate?
There are a number of medications that your doctor can prescribe in place of Fenofibrate. Compare a few possible alternatives below.
News about Fenofibrate
10 Fenofibrate Side Effects: What to Expect From Taking Tricor, Trilipix, and More
Fenofibrate is a medication that can help manage high cholesterol and high triglycerides. Common fenofibrate side effects include digestive issues, headaches, and muscle pain.
Fenofibrate Dosages: Your GoodRx Guide for Tricor, Trilipix, and More
Fenofibrate is a medication to lower cholesterol and triglyceride levels. Fenofibrate dosages are individualized and may be adjusted over time.
What Is Fenofibrate? And Does it Help to Treat COVID-19 Infections?
Fenofibrate is often taken to help with high cholesterol. But other uses are being studied — including the use of fenofibrate in fighting COVID-19 infections.
Fenofibrate images
