Key takeaways:
Entyvio (vedolizumab) can cost over $20,000 per year without insurance. What you pay for Entyvio depends largely on whether you have insurance coverage and your plan details. Where you live, what form you’re using, and other factors also affect the cost.
The Entyvio infusion is given in a healthcare setting. So it has additional costs to consider, such as administration fees, that don’t apply to the at-home injections. The infusion may be covered under medical insurance instead of prescription insurance.
If you qualify, the manufacturer’s copay program could help you save on the cost of your medication.
Save on related medications
Entyvio (vedolizumab) is an injectable biologic that treats Crohn’s disease and ulcerative colitis. It’s a specialty medication, which means that it’s typically only available through a specialty pharmacy or directly from the medical office where you receive infusions. It also means that Entyvio comes at a higher cost than many nonspecialty prescription medications.
Let’s take a look at how much Entyvio costs without insurance and ways to save on your prescription.
How much does Entyvio cost without insurance?
Entyvio can cost over $20,000 per year without insurance. It comes as an IV infusion, a prefilled syringe, and an injection pen.
Keep in mind that you’ll receive your first two doses of Entyvio as an infusion. The infusion is administered in a medical setting. So there may be extra costs beyond the medication itself, such as administration fees. Your healthcare team and insurance company (if applicable) can provide more information about the additional costs for an Entyvio infusion.
What factors affect the cost of Entyvio?
There are several factors that can affect the cost of Entyvio.
Generic availability
Entyvio is a reference (“brand-name”) biologic medication. Some biologic medications have one or more biosimilars. A biosimilar is a lower-cost version of a biologic that’s similar to a generic.
Entyvio biosimilars aren’t expected to be available until 2028. But they may help you access Entyvio at a lower cost once approved.
Dosage and quantity
As mentioned, Entyvio prices can vary depending on which form you’re using. The injections you can give yourself at home may be more cost-effective than an infusion. Talk to your prescriber about your options.
Location
Where you live plays a role in the cash prices of your medications. For instance, prices for prescription medications are generally lower in Tampa, Florida, than in New York City.
Pharmacy
Since Entyvio is a specialty medication, it isn’t usually available at local pharmacies. Instead, it’s filled and shipped to you by a specialty pharmacy. But which specialty pharmacy you choose can play a role in the cash price. So it’s often worth shopping around to compare prices.
Good to know: The Entyvio infusion is usually supplied by your infusion center. So you likely won’t need to bring it with you to your appointment.
Insurance coverage
If you have prescription insurance, how much you pay for Entyvio will depend on where it’s placed within your plan’s formulary (list of covered medications). Most insurance plans have tiers, or levels, within their formulary. Lower-tier medications typically have a lower copay, while higher-tier medications typically have a higher copay. Your plan’s formulary should be available online, or you can call the number on the back of your prescription insurance card.
Entyvio infusions may be covered under your medical insurance instead of your prescription insurance. That’s because they’re administered in a healthcare setting. The costs involved can vary depending on what type of coverage you have. You may pay a flat fee or a percentage of a visit’s cost, for example. You can usually find this information online or by calling the customer service number on the back of your insurance card.
What to do if Entyvio isn’t covered by your insurance
If your insurance doesn’t cover Entyvio, try these options:
Request a formulary exception from your insurance company. You can also file an appeal if your claim is denied.
Talk to your prescriber about potential Entyvio alternatives, such as Omvoh (mirikizumab-mrkz), to see if there’s an option that’s covered by your insurance plan.
When your next open enrollment window comes, look for a health insurance plan that includes Entyvio as a covered medication.
Ways to save on Entyvio
There are ways to save on the cost of Entyvio. Some options require insurance coverage, while others help reduce the cash price. Here are four savings strategies to consider.
1. See if you qualify for a copay savings program
If you have commercial insurance, you could pay as little as $0 per dose of Entyvio through a savings program from the manufacturer. The program, called EntyvioConnect, has a maximum benefit of $20,000 per year. To be eligible, you must:
Have commercial insurance
Have a valid Entyvio prescription for an FDA-approved use
Be a resident of the U.S., Puerto Rico, or another U.S. territory
Not be enrolled in a government-funded health insurance program, such as Medicare, Medicaid, or Tricare
EntyvioConnect also offers the medication at no cost (for up to 3 years) to people who don’t have insurance coverage for the medication. For those who experience a loss or gap in insurance coverage during treatment, the program offers Entyvio at no cost for up to 6 months.
You can apply for EntyvioConnect online or call 1-844-368-9846 for assistance.
2. Ask about a 90-day supply
If you have insurance, your plan may offer Entyvio at a lower monthly cost if you fill a 90-day (3-month) supply instead of 1 month at a time. This only applies to the syringe and injection pen that you can administer yourself at home.
3. Tap into your HSA, FSA, or HRA
If you have a health savings account (HSA), a flexible spending account (FSA), or a health reimbursement arrangement (HRA), you can use it to help cover your out-of-pocket costs for Entyvio. These tax-advantaged healthcare accounts let you pay for eligible expenses with tax-free dollars.
Pay directly with your HSA or FSA card at the pharmacy, or cover the cost yourself and submit a request for reimbursement. The funds in HSAs and HRAs typically roll over annually, but you have to use FSA dollars before the deadline or they’ll expire.
4. Ask your prescriber about lower-cost alternatives
As mentioned, Entyvio doesn’t have a biosimilar available yet. But other biologics for inflammatory bowel disease may have lower-cost biosimilar options. Examples include Humira (adalimumab) and Remicade (infliximab). Talk to your prescriber about your options.
The bottom line
Entyvio (vedolizumab) is an injectable biologic that treats inflammatory bowel disease. It can cost over $20,000 per year without insurance. What you pay for Entyvio depends on whether you have insurance coverage, where you live, and what form you’re using, among other factors. The manufacturer’s copay program could help you save on the cost of your medication.
The Entyvio infusion is given in a healthcare setting. So it has additional costs, such as administration fees, that don’t apply to the at-home injections. The infusion may be covered under medical insurance instead of prescription insurance.
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References
Entyvio. (n.d.). Cost support. Takeda Pharmaceuticals U.S.A.
Entyvio. (2023). EntyvioConnect: Co-pay terms and conditions. Takeda Pharmaceuticals U.S.A.
Entyvio. (2025). EntyvioConnect: Enrollment and prescription form. Takeda Pharmaceuticals U.S.A.
Grand View Research. (2025). Vedolizumab (Entyvio) market: Facing the patent cliff and intensifying competitive landscape.
Myshko, D. (2024). FDA approves pen form of Entyvio for Crohn’s disease. Managed Healthcare Executive.
Takeda Pharmaceuticals America. (2026). Entyvio - vedolizumab injection, powder, lyophilized, for solution, Entyvio Pen - vedolizumab injection, solution, Entyvio - vedolizumab injection, solution [package insert].
