Type your drug name (like Atorvastatin, Sildenafil, etc)
EfavirenzGeneric Sustiva
EFAVIRENZ is an antiretroviral medicine. It is used with other medicines to treat HIV. This medicine is not a cure for HIV. It will not stop the spread of HIV to others. The lowest GoodRx price for the most common version of efavirenz is around $288.23, 71% off the average retail price of $1,025.52. Compare HIV NNRTIs.
Prescription Settings
30 capsules
30 capsules

Efavirenz Side Effects

What should I watch for?

Visit your doctor or health care professional for regular checkups. Discuss any new symptoms with your doctor. You will need to have important blood work done while on this medicine.

HIV is spread to others through sexual or blood contact. Talk to your doctor about how to stop the spread of HIV.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Avoid alcohol and mood altering (street) drugs while taking this medicine because they can make these side effects worse.

Birth control pills may not work properly while you are taking this medicine. Talk to your doctor about using an extra method of birth control. Women who can still have children must use a reliable form of barrier contraception, like a condom or diaphragm.


Common and Rare Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common


skin rash or itching

Less common

Blood in the urine

difficult or painful urination

pain in the lower back or side


Abdominal or stomach pain


changes in vision

clumsiness or unsteadiness


convulsions (seizures)


dark urine


double vision


fast or pounding heartbeat

fever or chills

headache (severe and throbbing)


inappropriate behavior

loss of appetite

mood or mental changes (severe)

muscle cramps or pain

nausea or vomiting

nerve pain

open sores

pain, tenderness, bluish color, or swelling of the leg or foot

rapid weight gain

seeing, hearing, or feeling things that are not there

sense of constant movement of self or surroundings

sores, ulcers, or white spots in the mouth or on the lips

speech disorder

swelling or tenderness in the upper abdominal or stomach area

swelling of the hands, arms, feet, or legs

thoughts of suicide or attempts at suicide

tightness in the chest

tingling, burning, numbness, or pain in the hands, arms, feet, or legs

tingling, burning, or prickling sensations


troubled breathing

unusual tiredness

weight loss

yellow eyes or skin

Incidence not known

Actions that are out of control

attack, assault, or force

continuing vomiting

decreased awareness or responsiveness

delusions of persecution, mistrust, suspiciousness, or combativeness

difficult or labored breathing

early appearance of redness or swelling of the skin

general feeling of tiredness or weakness

irregular heartbeat recurrent


late appearance of rash with or without weeping blisters that become crusted, especially in sun-exposed areas of the skin, may extend to unexposed areas

light-colored stools

mimicry of speech or movements




peculiar postures or movements, mannerisms, or grimacing

severe sleepiness

talking, feeling, and acting with excitement

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common





increased sweating

poor concentration

trouble sleeping

Less common or rare

Abnormally decreased sensitivity, particularly to touch

agitation or anxiety


change in sense of taste or smell

dry mouth

excessive gas

false sense of well-being

flaking and falling off of the skin


general feeling of discomfort



joint pain

lack of feeling or emotion

loss of hair

loss of memory

loss of sense of reality

mood changes


painful, red, hot, or irritated hair follicles

ringing in the ears

stomach discomfort

unusual dreams


Incidence not known

Difficulty having a bowel movement (stool)

discoloration of the fingernails or toenails

dizziness or lightheadedness

feeling of constant movement of self or surroundings

increased amount of fat in the upper back and neck, or around the chest and stomach area

lose fat from the legs, arms, and face

sensation of spinning

swelling of the breasts or breast soreness in both females and males

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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