Is chlorothiazide/reserpine still available?

No, chlorothiazide/reserpine has been [discontinued](https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=011635) and is no longer available in the United States. It's not clear why chlorothiazide/reserpine was discontinued.

Are there currently available medications that are used in place of chlorothiazide/reserpine?

Yes. Although [reserpine](https://www.goodrx.com/reserpine/what-is) as a single-ingredient medication has also been discontinued, [chlorothiazide (Diuril)](https://www.goodrx.com/chlorothiazide/what-is) is still available. There are also other [available medications that work well for treating high blood pressure](https://www.goodrx.com/conditions/hypertension/high-blood-pressure-medications).

Diupres

Q: What is chlorothiazide/reserpine?

Chlorothiazide/reserpine is made up of two medications that both lower your blood pressure. [__Chlorothiazide__](https://www.goodrx.com/chlorothiazide/what-is) is a thiazide diuretic (water pill) that [works in the kidneys](https://www.ahajournals.org/doi/10.1161/01.cir.26.1.121) to remove extra water, which lowers blood pressure and gets rid of swelling. [__Reserpine__](https://www.goodrx.com/reserpine/what-is) is a [*Rauwolfia* alkaloid](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4566472/) that [works by](https://www.ncbi.nlm.nih.gov/books/NBK557767/#article-28402.s3) lowering the levels of certain chemicals in your body that can raise your blood pressure.

chlorothiazide and reserpine

Used for Heart Failure, Hypertension

Chlorothiazide/reserpine is a combination medication used to lower blood pressure. It's no longer available in the United States because it was discontinued.

Reviewed by:

Robert Chad Hakim, PharmD, BCCCP

Allison Gourley, PharmD

Last reviewed on June 27, 2022

What is Chlorothiazide/reserpine?

What is Chlorothiazide/reserpine used for?

High blood pressure

Are you looking for information on chlorothiazide (Diuril), hydrochlorothiazide (Microzide), or Hydropres (reserpine / hydrochlorothiazide) instead?

Drug facts

Common Brands	Diupres(brand no longer available)
Drug Class	Diuretic / Rauwolfia alkaloid
Controlled Substance Classification	Not a controlled medication
Generic Status	No lower-cost generic available
Availability	Discontinued

Common Brands

Diupres(brand no longer available)

Drug Class

Diuretic / Rauwolfia alkaloid

Controlled Substance Classification

Not a controlled medication

Generic Status

No lower-cost generic available

Availability

Discontinued

Common questions about Diupres

Diupres is made up of two medications that both lower your blood pressure. Chlorothiazide is a thiazide diuretic (water pill) that works in the kidneys to remove extra water, which lowers blood pressure and gets rid of swelling. Reserpine is a Rauwolfia alkaloid that works by lowering the levels of certain chemicals in your body that can raise your blood pressure.

No, Diupres has been discontinued and is no longer available in the United States. It's not clear why Diupres was discontinued.

Yes. Although reserpine as a single-ingredient medication has also been discontinued, chlorothiazide (Diuril) is still available. There are also other available medications that work well for treating high blood pressure.