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Postpartum Depression

Is Postpartum Depression Treatment Safe While Breastfeeding?

Some, but not all, treatments for PPD are safe to take while nursing.

Lauren Smith, MABrian Clista, MD
Written by Lauren Smith, MA | Reviewed by Brian Clista, MD
Updated on January 17, 2026
Featuring Naomi Torres-Mackie, PhDReviewed by Brian Clista, MD | January 17, 2026

Not all antidepressants are safe to take while nursing. This can pose a challenge for treating postpartum depression (PPD).

In this video, learn which medications for PPD are safe while nursing, according to Naomi Torres-Mackie, PhD, Clinical Psychologist at Lenox Hill Hospital, Northwell Health. Plus, learn what research is showing so far for newer PPD medications.

References

American College of Obstetricians and Gynecologists. (2021). Postpartum depression.

Bullock, A., et al. (2022). An open-label study to evaluate concentrations of zuranolone in the breast milk of healthy lactating women

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Lauren Smith, MA
Written by:
Lauren Smith, MA
Lauren Smith, MA, has worked in health journalism since 2017. Before joining GoodRx, she was the senior health editor and writer for HealthiNation.
Brian Clista, MD
Reviewed by:
Brian Clista, MD
Dr. Clista is a board-certified pediatrician who works in private practice in Pittsburgh, Pennsylvania. He previously served as a National Health Service Corporation Scholar in the inner city of Pittsburgh for 11 years.

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