A flare-up of multiple sclerosis (MS), also known as an attack or a relapse, is when you have new MS symptoms or the worsening of old symptoms.
Flare-ups are caused by inflammation within the central nervous system (CNS), which is made up of the brain and the spinal cord. This inflammation damages myelin, which is a protective sheath that coats your nerve cells. When this happens, your nerve impulses are slowed down and you may have symptoms of MS, such as vision difficulties, weakness, numbness, or balance problems.
When should you call your doctor about an MS flare-up?
If you think you’re experiencing a flare-up of your MS, you should contact your provider and let them know.
“I always tell my patients to contact me with any concerning symptom, anything, especially if it’s lasting,” says Asaff Harell, MD, Neurologist and Director of the Multiple Sclerosis Center at Lenox Hill Hospital in New York City.
If you are indeed having a relapse of your MS, it means that you’re experiencing new inflammation in your CNS, and that may be creating new lesions or scars. Other times, Harel says, you can have fluctuations in your symptoms that may seem like you are having a relapse, but you actually don’t have new inflammation.
That’s why it’s important to check in with your provider to make sure that your symptoms are actually related to MS.
“Just because somebody has MS, doesn’t mean that there couldn’t be other things going on,” says Dr. Harel.
Mild vs. severe MS flare-ups
If you’re having a more mild flare-up of MS, you might experience a little bit of numbness without any weakness or incoordination. Your ability to carry out your everyday activities might not be affected. In this case, you may not need any treatment, and the flare-up may go away on its own.
But if you’re having a more severe flare-up that does impact your physical functioning, Dr. Harel says you could benefit from treatment with corticosteroids, which helps decrease inflammation, as well as physical therapy.
- PrednisoneGeneric Deltasone and Rayos and Sterapred
- MedrolMethylprednisolone
- KenalogTriamcinolone
What should you do if you are having frequent MS flares?
If your MS flare-ups are happening frequently, it could be a sign that your current treatment isn’t the right fit for you.
“We have a lot of different options as far as preventative therapy goes,” Dr. Harel says. “If one doesn't work as well as we’d like, there are other options that we can escalate to, and this is the good thing about the modern era.”
Asaff Harel, MD, is a Neurologist specializing in multiple sclerosis and related neuro-immunological conditions, serving as the Director of the Multiple Sclerosis Center at Lenox Hill Hospital, Northwell Health.
References
Kalincik, T. (2015). Multiple sclerosis relapses: Epidemiology, outcomes and management. A systematic review. Neuroepidemiology.
Multiple Sclerosis Trust. (2019). Central nervous system (CNS).
National Institute of Neurological Disorders and Stroke. (2024). Multiple sclerosis.
National Multiple Sclerosis Society. (n.d.). Managing relapses in multiple sclerosis.
National Multiple Sclerosis Society. (n.d.). Rehabilitation and multiple sclerosis.
Why trust our experts?










