provider image
Welcome! You’re in GoodRx for healthcare professionals. Now, you’ll enjoy a streamlined experience created specifically for healthcare professionals.
Skip to main content

GoodRx Guide

Long COVID

Comprehensive information for you or a loved one — including treatment options and discounts on popular medications.
Alice Perlowski, MD, MA, FACCMandy Armitage, MD
Updated on September 24, 2024

Definition

“Long COVID” is a condition of symptoms that last 3 months or more after infection with COVID-19. Other names for it include: 

  • Long-haul COVID

  • Chronic COVID

  • Post-COVID condition (PCC)

  • Post-acute sequelae of SARS-CoV-2 (PASC

Long COVID can affect almost any organ in the body. But some of the most common symptoms are fatigue, shortness of breath, and headache (more on this below). It can affect both children and adults. And it can happen even after mild or asymptomatic (no symptoms) illness with COVID. 

It’s difficult to determine how many people have been affected or can be affected by long COVID. Estimates range from 3% to 38% of people previously infected with COVID. This is due to differences in how it has been defined and monitored. Most recent survey data suggests around 5.5% of U.S. adults have long COVID. 

To address this discrepancy and others, the National Institutes of Health (NIH) is conducting a large, multi-year research program on long COVID. It aims to better understand the causes and symptoms, determine a universal definition, and find effective treatments. This program is called Researching COVID to Enhance Recovery (RECOVER).

Causes

Researchers haven’t pinpointed one single cause of long COVID. But they now understand that COVID is unlike other viral infections in its complexity. It affects several different systems in the body and interferes with many cellular and molecular pathways. So, finding a single “cause” of long COVID is unlikely. 

That said, research has shed some light on the following pathways that likely contribute to long COVID:

  • Remaining virus: Some people with long COVID might not be able to get rid of the virus. Some evidence suggests that people with long COVID are more likely to have COVID proteins in their tissues more than a year after their original infection. Others have found that the virus continues to replicate in many organs, where it can continue to directly harm those tissues. 

  • Changes in the immune system: COVID may trigger the immune system to respond differently in certain people. It can also cause persistent overactivation of the immune system. This chronic inflammation can lead to many of the symptoms of long COVID.

  • Reactivation of other viruses: COVID can reactivate other viruses that linger in the body. For example, people with long COVID are more likely to show signs that an old infection with Epstein-Barr virus (EBV), the virus that causes mono, was reactivated. 

  • Changes to the gut microbiome: People with long COVID are more likely to have changes to their gut microbiome 6 months after illness. There’s evidence that the type of bacteria found in the gut is associated with certain long COVID symptoms. 

  • Damage to the vascular system: Studies suggest the virus can harm the endothelium, which is the inner lining of blood vessels. This damage plus activation of certain blood components can cause clots in small vessels and further inflammation.

Risk factors

Certain factors can increase your risk for developing long COVID after COVID infection. These risk factors include:

  • Older age

  • Female sex

  • Body mass index (BMI) 30 or greater

  • Smoking

  • Medical conditions, including diabetes, chronic obstructive pulmonary disease (COPD), asthma, heart disease, immunosuppressive disorders, and obstructive sleep apnea

  • Lower socioeconomic status

With regard to COVID and vaccinations, the following increase the risk of long COVID: 

  • First COVID infection, as opposed to additional infections

  • Infection with early variants (before Omicron)

  • Requiring in-hospital care

  • Fewer than 2 vaccinations (risk decreases with each booster)

Symptoms

Many symptoms involving all organ systems have been linked to long COVID. In an effort to better define this condition, the RECOVER working group identified 12 key symptoms that can help separate long COVID from other conditions 6 months or more after infection:

  • Post-exertional malaise (the worsening of symptoms after physical or mental activity)

  • Fatigue

  • Brain fog

  • Dizziness

  • Gut symptoms

  • Heart palpitations

  • Sexual problems

  • Change in smell or taste

  • Thirst

  • Chronic cough

  • Chest pain

  • Abnormal movements such as muscle twitching or jerking

But that doesn’t mean these are the only symptoms possible. Other commonly reported symptoms of long-COVID include:

  • Shortness of breath

  • Headache

  • Skin changes

  • Sleep disturbance

  • Joint pain

It’s important to note that long COVID doesn’t look the same for everyone. For example, one study found that: 

  • Black and Hispanic adults were more likely to have joint pain and headache. 

  • White adults were more likely to have sleep disorders, problems with thinking, or fatigue.

Related Health Conditions

Diagnosis

There’s no specific test to diagnose long COVID. Long COVID can be a continuation of symptoms from the original COVID infection or new symptoms that develop as many as 3 months later.

A positive COVID test isn’t needed to diagnose long COVID. Some people may not know when they were originally infected. 

If you have symptoms of long COVID, your primary care provider will take a full medical history and perform a physical exam. Then, based on your symptoms, they’ll decide which labs and imaging tests you may need. They may order additional tests to rule out other conditions as well.

As researchers learn more about long COVID, better testing will become available for this condition. In the meantime, primary care physicians are working together with specialists to provide care for people with this condition.

Treatments

There are no specific treatments for long COVID at the moment. Research is underway, including clinical trials, to find better treatments. 

In the meantime, the goal of treatment is to alleviate symptoms. Some of the symptoms of long COVID overlap with other syndromes such as myalgic encephalomyelitis (chronic fatigue syndrome) and postural orthostatic tachycardia syndrome (POTS). 

So, some of the same strategies can be used to reduce symptoms. For example:

Pulmonary rehabilitation can improve breathlessness, function, and even quality of life.

Living

Millions of people in the U.S. and around the world are living with long COVID. As many as 25% of them say it affects their day-to-day living. Symptoms can be severe enough to prevent people from returning to their daily life or work. It can qualify as a disability and require accommodations, according to the Americans with Disabilities Act (ADA).

If you or a loved one is living with long COVID, you may be searching for something that can help. Here are a few tips to consider:

  • Exercise: Many people experience post-exertional malaise, or relapses of symptoms, after physical exercise. Before exercising again, talk with your healthcare team for guidance. Recommendations for your physical rehabilitation may differ depending on your individual health issues and condition.

  • Work: Talk with your primary care provider before returning to work. And consider asking your employer for a reduced work schedule or special accommodations because of your condition.

  • Sleep: Quality sleep is important for healing the body and mind. But it might be tough to get if long COVID is affecting your sleep. Improving or trying sleep hygiene, meditation, and even therapy can help. 

  • Support: There are many support groups on social media and online for people with long COVID and their caregivers. Connecting with others can be helpful for your mental health. Consider working with a mental health specialist if you’re struggling with your well-being.

Frequently asked questions

Do the COVID vaccines help prevent long COVID?

Yes. If you’re vaccinated against COVID, you’re less likely to develop long COVID after getting sick. And people who got 3 COVID shots have an even lower chance of getting long COVID than those who got 1 shot. 

Vaccination remains the best preventive strategy for everyone. Fully vaccinated people who get COVID are less likely to develop severe illness needing hospitalization. And they’re less likely to develop long COVID symptoms.

Can you have long COVID without ever having a positive COVID test?

Yes. Reverse-transcription polymerase chain reaction (RT-PCR) and/or serologic (antibody) tests aren’t required to diagnose long COVID, according to the CDC. Healthcare professionals should use clinical judgment to determine if a person is experiencing a post-COVID condition.

Are people with long COVID contagious to other people?

Usually not. The virus that causes COVID can only be detected in the nose and throat for an average of 2 weeks after a person first has symptoms. If someone has long COVID, that means they’ve had symptoms for months, so it’s outside the window of viral shedding.

Can you catch COVID again if you have long COVID?

Yes, it’s possible for someone with long COVID to get reinfected with COVID. If you have long COVID, getting COVID again can worsen your long COVID symptoms. This is why it’s important to stay up to date with COVID vaccines to lower your chance of getting infected again. 

Can you recover from long COVID? 

Unfortunately, there’s not much data yet on recovery. But survey data suggests fewer people are now reporting symptoms of long COVID than before. And this study found that about 83% of people who had persistent symptoms at 6 months after infection reported recovery at 24 months.

View All References (33)

Boufidou, F., et al. (2023). SARS-CoV-2 reinfections and long COVID in the post-Omicron phase of the pandemic. International Journal of Molecular Sciences.

Bull-Otterson, L., et al. (2022). Post–COVID conditions among adult COVID-19 survivors aged 18–64 and ≥65 Years — United States, March 2020–November 2021. Centers for Disease Control and Prevention.

Burns, A. (2024). As recommendations for isolation end, how common is long COVID? Kaiser Family Foundation.

Centers for Disease Control and Prevention. (2024). Living with long COVID.

Centers for Disease Control and Prevention. (2024). Long COVID.

Centers for Disease Control and Prevention. (2024). Long COVID basics.

Constantinescu-Bercu, A., et al. (2023). Long COVID: Molecular mechanisms and detection techniques. International Journal of Molecular Sciences.

Covid.gov. (2024). 2024 NASEM long COVID definition.

da Silva, R., et al. (2024). The silent syndrome of long COVID and gaps in scientific knowledge: A narrative review. Viruses.

DeMars, J., et al. (2023). What is safe long COVID rehabilitation? Journal of Occupational Rehabilitation.

Doctrow, B. (2023). Immune and hormonal features of long COVID. National Institutes of Health.

Donald, J., et al. (2024). Exploring the complexities of long COVID. Viruses.

Gold, J. E., et al. (2021). Investigation of long COVID prevalence and its relationship to Epstein-Barr virus reactivation. Pathogens.

Lundberg-Morris, L., et al. (2023). Covid-19 vaccine effectiveness against post-Covid-19 condition among 589,722 individuals in Sweden: Population based cohort study. The BMJ.

Li, J., et al. (2023). The long-term health outcomes, pathophysiological mechanisms and multidisciplinary management of long COVID. Signal Transduction and Targeted Therapy.

Liu, Q., et al. (2022). Gut microbiota dynamics in a prospective cohort of patients with post-acute COVID-19 syndrome. Gut.

Meléndez-Oliva, E., et al. (2023). Efficacy of pulmonary rehabilitation in post-COVID-19: A systematic review and meta-analysis. Biomedicines.

National Institutes of Health. (2023). NIH RECOVER research identifies potential long COVID disparities.

Proal, A. D., et al. (2023). SARS-CoV-2 reservoir in post-acute sequelae of COVID-19 (PASC). Nature Immunology.

RECOVER. (n.d.). RECOVER clinical trials.

RECOVER. (n.d.). RECOVER leadership.

RECOVER. (2023). Obstructive sleep apnea associated with increased risks for long COVID

RECOVER. (2024). Routine lab tests are not a reliable way to diagnose long COVID.

Sánchez-García, J. C., et al. (2023). Long COVID and physical therapy: A systematic review. Diseases.

Soriano, J. B., et al. (2022). A clinical case definition of post-COVID-19 condition by a Delphi consensus. The Lancet.

Stein, S. R. (2022). SARS-CoV-2 infection and persistence in the human body and brain at autopsy. Nature.

Tsampasian, V., et al. (2023). Risk factors associated with post−COVID-19 condition: A systematic review and meta-analysis. JAMA Internal Medicine.

Thaweethai, T., et al. (2023). Development of a definition of postacute sequelae of SARS-CoV-2 infection. JAMA.

Universitätsmedizin Halle. (2024). Study on post-COVID-19 condition: Which factors have an impact on the risk.

U.S. Department of Health and Human Services. (2024). Guidance on “Long COVID” as a disability under the ADA, Section 504, and Section 1557.

Walsh, K. A., et al. (2020). SARS-CoV-2 detection, viral load and infectivity over the course of an infection. The Journal of Infection.

Watanabe, A., et al. (2023). Protective effect of COVID-19 vaccination against long COVID syndrome: A systematic review and meta-analysis. Vaccine.

Yin, Kailin. (2024). Long COVID manifests with T cell dysregulation, inflammation and an uncoordinated adaptive immune response to SARS-CoV-2. Nature Immunology.

GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.

Get the facts on Long COVID.

Sign up for our newsletter to get expert tips on condition management and prescription savings.

By signing up, I agree to GoodRx's Terms and Privacy Policy, and to receive marketing messages from GoodRx.

Latest Articles