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Zilretta vs. Synvisc

Zilretta (triamcinolone) is a steroid injection used to treat knee pain from osteoarthritis in adults. It works by reducing inflammation in the joint, helping to relieve pain and stiffness. The typical dose is 32 mg injected directly into the knee (intra-articular) by a healthcare professional. Some potential side effects include joint swelling, cough, and bruising where the medication is injected.

• Pain from osteoarthritis of the knee

• Joint swelling (3%)
• Bruising at the injection site (2%)
• Sinus infection (2%)
• Cough (2%)

• Serious nervous system problems
• Severe allergic reactions
• Greater risk of infections
• Hormone effects
• Heart and kidney problems
• Eye problems
• Stomach problems
• Bone problems
• Changes in mood and behavior

Synvisc (hylan G-F 20) is a viscosupplement used to treat knee pain due to osteoarthritis (OA) in adults. It's an option for people who still have pain despite having tried certain treatments, like exercise and acetaminophen (Tylenol). Synvisc (hylan G-F 20) is a type of knee joint gel that's injected directly into the knee by a healthcare professional (HCP) to lubricate the joint. Synvisc is given as 3 weekly injections, whereas Synvisc-One is given as a single injection. Side effects include injection site reactions, such as redness, pain, and swelling around the knee.

• Pain due to osteoarthritis (OA) of the knee

Synvisc:

• Knee pain and swelling (7%)

Synvisc-One:

• Joint pain (25%)
• Joint stiffness (8%)
• Joint swelling (up to 6%)

• Severe allergic reaction
• Serious skin damage