Zilretta vs. Synvisc for Osteoarthritis: Important Differences and Potential Risks.

Zilretta

(triamcinolone)

Synvisc

(hylan G-F 20)

Summary for Zilretta

Prescription only

Zilretta (triamcinolone) is a steroid injection used to treat knee pain from osteoarthritis in adults. It works by reducing inflammation in the joint, helping to relieve pain and stiffness. The typical dose is 32 mg injected directly into the knee (intra-articular) by a healthcare professional. Some potential side effects include joint swelling, cough, and bruising where the medication is injected.

Indications for Zilretta

Pain from osteoarthritis of the knee

Pros and Cons for Zilretta

Pros

Injected directly into the affected knee joint
Single injection per treatment
Lasts up to 3 months or longer

Cons

Must be given by a trained healthcare professional
Unknown if safe during pregnancy or breastfeeding
Side effects include joint swelling and bruising at the injection site

Common Side Effects for Zilretta

Joint swelling (3%)
Bruising at the injection site (2%)
Sinus infection (2%)
Cough (2%)

Warnings for Zilretta

Serious nervous system problems
Severe allergic reactions
Greater risk of infections
Hormone effects
Heart and kidney problems
Eye problems
Stomach problems
Bone problems
Changes in mood and behavior

Summary for Synvisc

Prescription only

Synvisc (hylan G-F 20) is a viscosupplement used to treat knee pain due to osteoarthritis (OA) in adults. It's an option for people who still have pain despite having tried certain treatments, like exercise and acetaminophen (Tylenol). Synvisc (hylan G-F 20) is a type of knee joint gel that's injected directly into the knee by a healthcare professional (HCP) to lubricate the joint. Synvisc is given as 3 weekly injections, whereas Synvisc-One is given as a single injection. Side effects include injection site reactions, such as redness, pain, and swelling around the knee.

Indications for Synvisc

Pain due to osteoarthritis (OA) of the knee

Pros and Cons for Synvisc

Pros

Only need 1 or 3 injections, depending on the brand name
Effects might last up to 1 year
Might delay time for total knee replacement surgery
Good option if other treatments for OA pain didn't work well

Cons

Must be given by a healthcare professional
Might not be the best option for people with an allergy to egg products
Can cause temporary pain at the injection site
Not studied in people age 21 years old or younger

Common Side Effects for Synvisc

Synvisc:

Knee pain and swelling (7%)

Synvisc-One:

Joint pain (25%)
Joint stiffness (8%)
Joint swelling (up to 6%)

Warnings for Synvisc

Severe allergic reaction
Serious skin damage

Prices with our coupons for Zilretta vs. Synvisc

Zilretta1 kit / 32mg vial of 5ml

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Synvisc1 kit / 3 syringes of 16mg/2ml

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Zilretta vs. Synvisc

Zilretta

Synvisc

Summary for Zilretta

Indications for Zilretta

Pros and Cons for Zilretta

Pros

Cons

Common Side Effects for Zilretta

Warnings for Zilretta

Summary for Synvisc

Indications for Synvisc

Pros and Cons for Synvisc

Pros

Cons

Common Side Effects for Synvisc

Warnings for Synvisc

Prices with our coupons for Zilretta vs. Synvisc

Browse medications by letter

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Zilretta

Synvisc

Summary for Zilretta

Indications for Zilretta

Pros and Cons for Zilretta

Pros

Cons

Common Side Effects for Zilretta

Warnings for Zilretta

Summary for Synvisc

Indications for Synvisc

Pros and Cons for Synvisc

Pros

Cons

Common Side Effects for Synvisc

Warnings for Synvisc