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Compare Zilretta vs. Synvisc

Head-to-head comparisons of medication uses, side effects, warnings, and more.

  • Zilretta (triamcinolone)
    Synvisc (hylan G-F 20)
  • Zilretta (triamcinolone)
    Synvisc (hylan G-F 20)

  • Summary of Zilretta vs. Synvisc

    Summary for Corticosteroid
    Prescription only

    Zilretta (triamcinolone) is a steroid injection used to treat knee pain from osteoarthritis in adults. It works by reducing inflammation in the joint, helping to relieve pain and stiffness. The typical dose is 32 mg injected directly into the knee (intra-articular) by a healthcare professional. Some potential side effects include joint swelling, cough, and bruising where the medication is injected.

    Summary for Viscoelastic
    Prescription only

    Synvisc (hylan G-F 20) is a viscosupplement used to treat knee pain due to osteoarthritis (OA) in adults. It's an option for people who still have pain despite having tried certain treatments, like exercise and acetaminophen (Tylenol). Synvisc (hylan G-F 20) is a type of knee joint gel that's injected directly into the knee by a healthcare professional (HCP) to lubricate the joint. Synvisc is given as 3 weekly injections, whereas Synvisc-One is given as a single injection. Side effects include injection site reactions, such as redness, pain, and swelling around the knee.

  • Indications of Zilretta vs. Synvisc

    Indications for
    •Pain from osteoarthritis of the knee
    Indications for
    •Pain due to osteoarthritis (OA) of the knee

  • Pros and Cons of Zilretta vs. Synvisc

    Pros and Const for Corticosteroid
    Pros
    •Injected directly into the affected knee joint
    •Single injection per treatment
    •Lasts up to 3 months or longer
    Cons
    •Must be given by a trained healthcare professional
    •Unknown if safe during pregnancy or breastfeeding
    •Side effects include joint swelling and bruising at the injection site
    Pros and Const for Viscoelastic
    Pros
    •Only need 1 or 3 injections, depending on the brand name
    •Effects might last up to 1 year
    •Might delay time for total knee replacement surgery
    •Good option if other treatments for OA pain didn't work well
    Cons
    •Must be given by a healthcare professional
    •Might not be the best option for people with an allergy to egg products
    •Can cause temporary pain at the injection site
    •Not studied in people age 21 years old or younger

  • Common Side Effects of Zilretta vs. Synvisc

    Common Side Effects for
    •Joint swelling (3%)
    •Bruising at the injection site (2%)
    •Sinus infection (2%)
    •Cough (2%)
    Common Side Effects for

    Synvisc:

    •Knee pain and swelling (7%)

    Synvisc-One:

    •Joint pain (25%)
    •Joint stiffness (8%)
    •Joint swelling (up to 6%)

  • Warnings of Zilretta vs. Synvisc

    Common Side Effects for
    •Serious nervous system problems
    •Severe allergic reactions
    •Greater risk of infections
    •Hormone effects
    •Heart and kidney problems
    •Eye problems
    •Stomach problems
    •Bone problems
    •Changes in mood and behavior
    Common Side Effects for
    •Severe allergic reaction
    •Serious skin damage

  • Prices with our coupons for Zilretta vs. Synvisc

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    Learn more about Synvisc

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