Key takeaways
Ethosuximide (Zarontin) and valproic acid (Depakene) are both antiepileptic medications, but they have some key differences. Ethosuximide is specifically used to treat absence (petit mal) seizures and is available in both pill and liquid forms. Valproic acid, on the other hand, treats a broader range of seizures, including focal impaired awareness seizures and absence seizures, and is also available in capsules and liquid solution. Ethosuximide is generally considered a first-choice treatment for absence seizures, while valproic acid can be used alone or with other medications for various seizure types. Valproic acid can severe side effects such as serious liver problems and birth defects, and requires regular blood work to monitor liver health. Ethosuximide can also cause serious liver problems as well as kidney problems. Both medications can cause drowsiness and require careful dose adjustments, but valproic acid interacts with more medications. Neither medication should be stopped suddenly without consulting your provider, as this can lead to withdrawal seizures.
