Key takeaways
Tizanidine (Zanaflex) and cyclobenzaprine (Flexeril) are both muscle relaxants, but they have some key differences. Tizanidine is an alpha-2 adrenergic receptor agonist that treats muscle stiffness and rigidity, often related to conditions like multiple sclerosis. It's taken up to three times a day and can cause side effects like low blood pressure, dry mouth, and sleepiness. Cyclobenzaprine, on the other hand, is used for short-term muscle pain and discomfort from acute conditions, such as injuries. It comes in immediate-release tablets taken three times a day or extended-release capsules taken once a day. Cyclobenzaprine can also cause drowsiness and dry mouth, but it has additional risks like serotonin syndrome when combined with certain medications. While both medications are available in generic forms, tizanidine is not recommended for people with liver or kidney problems, whereas cyclobenzaprine should be used cautiously in those with liver issues.
