Compare
Sunosi vs. Wakix

Sunosi (solriamfetol) is used to improve wakefulness in adults with narcolepsy or obstructive sleep apnea. Sunosi (solriamfetol) belongs to the drug class called dopamine and norepinephrine reuptake inhibitors, and it's currently only available as a brand-name medication. Sunosi (solriamfetol) is available as tablets that are taken by mouth once daily when you first wake up. Common side effects include headache, a smaller appetite, and nausea.

Extreme daytime sleepiness caused by:

• Narcolepsy
• Obstructive sleep apnea (OSA)

• Headache (16%)
• Having a smaller appetite (9%)
• Nausea (7%)
• Anxiety (6%)
• Insomnia (trouble sleeping, 5%)

Note: Side effect percentages were reported from studies of adults with narcolepsy. These percentages might differ slightly for adults with obstructive sleep apnea.

• High blood pressure and fast heart rate
• Symptoms of mental health problems

Wakix (pitolisant) is a medication that treats excessive daytime sleepiness in adults and children ages 6 and older with narcolepsy. It's also used to treat cataplexy, or sudden muscle weakness after having strong emotions, in adults with narcolepsy. This medication is taken by mouth once a day in the morning. You'll typically start the medication at a lower dose and then slowly raise the dose over time. Side effects include headache, nausea, and trouble sleeping.

• Excessive daytime sleepiness or cataplexy (sudden muscle weakness) in adults with narcolepsy
• Excessive daytime sleepiness in children ages 6 and older with narcolepsy

Adults:

• Headache (18%)
• Trouble sleeping (6%)
• Nausea (6%)
• Anxiety (5%)

Children:

• Headache (19%)
• Trouble sleeping (7%)

• Life-threatening abnormal heart rhythm (QT prolongation)