Skip to main content
HomeDrug Comparisons
Drug bottle and Pill

Compare Sunosi vs. Wakix

Head-to-head comparisons of medication uses, side effects, warnings, and more.

  • Sunosi (solriamfetol)
    Wakix (pitolisant)
  • Sunosi (solriamfetol)
    Wakix (pitolisant)

  • Summary of Sunosi vs. Wakix

    Summary for Dopamine and norepinephrine reuptake inhibitor
    Prescription only

    Sunosi (solriamfetol) is used to improve wakefulness in adults with narcolepsy or obstructive sleep apnea. Sunosi (solriamfetol) belongs to the drug class called dopamine and norepinephrine reuptake inhibitors, and it's currently only available as a brand-name medication. Sunosi (solriamfetol) is available as tablets that are taken by mouth once daily when you first wake up. Common side effects include headache, a smaller appetite, and nausea.

    Summary for Histamine-3 (H3) receptor antagonist / Inverse agonist
    Prescription only

    Wakix (pitolisant) is a medication that treats excessive daytime sleepiness in adults and children ages 6 and older with narcolepsy. It's also used to treat cataplexy, or sudden muscle weakness after having strong emotions, in adults with narcolepsy. This medication is taken by mouth once a day in the morning. You'll typically start the medication at a lower dose and then slowly raise the dose over time. Side effects include headache, nausea, and trouble sleeping.

  • Indications of Sunosi vs. Wakix

    Indications for

    Extreme daytime sleepiness caused by:

    •Narcolepsy
    •Obstructive sleep apnea (OSA)
    Indications for
    •Excessive daytime sleepiness or cataplexy (sudden muscle weakness) in adults with narcolepsy
    •Excessive daytime sleepiness in children ages 6 and older with narcolepsy

  • Pros and Cons of Sunosi vs. Wakix

    Pros and Const for Dopamine and norepinephrine reuptake inhibitor
    Pros
    •Taken once a day
    •Comes in two different strengths
    •Unlikely to cause withdrawal symptoms if you stop taking the medication suddenly
    Cons
    •No lower-cost generic available
    •Can make your blood pressure go up
    •Is a controlled substance so there are special requirements to getting a prescription filled
    •Not approved for children
    Pros and Const for Histamine-3 (H3) receptor antagonist / Inverse agonist
    Pros
    •Lowers how many cataplexy attacks you get per week
    •A narcolepsy treatment that's not a controlled substance
    •Only need to take it once a day
    Cons
    •Not the best medication if you have liver or kidney problems
    •Might need to take more than one tablet for your dose
    •Can take a couple months to see the full effects of this medication

  • Common Side Effects of Sunosi vs. Wakix

    Common Side Effects for
    •Headache (16%)
    •Having a smaller appetite (9%)
    •Nausea (7%)
    •Anxiety (6%)
    •Insomnia (trouble sleeping, 5%)

    Note: Side effect percentages were reported from studies of adults with narcolepsy. These percentages might differ slightly for adults with obstructive sleep apnea.

    Common Side Effects for

    Adults:

    •Headache (18%)
    •Trouble sleeping (6%)
    •Nausea (6%)
    •Anxiety (5%)

    Children:

    •Headache (19%)
    •Trouble sleeping (7%)

  • Warnings of Sunosi vs. Wakix

    Common Side Effects for
    •High blood pressure and fast heart rate
    •Symptoms of mental health problems
    Common Side Effects for
    •Life-threatening abnormal heart rhythm (QT prolongation)

  • Prices with our coupons for Sunosi vs. Wakix

    Learn more about Sunosi
    Learn more about Wakix

Compare other Narcolepsy drugs

Sunosi vs AdderallSunosi vs WellbutrinWakix vs SunosiXywav vs SunosiAdderall vs ConcertaAdderall vs StratteraAdderall vs XanaxAdderall Xr vs AdderallArmodafinil vs AdderallAtivan vs AdderallAzstarys vs AdderallDaytrana vs AdderallDesoxyn vs AdderallDexedrine vs AdderallDextroamphetamine vs AdderallEvekeo vs AdderallFocalin vs AdderallGuanfacine vs AdderallIntuniv vs AdderallKapvay vs AdderallLexapro vs AdderallModafinil vs AdderallMydayis vs AdderallNamenda vs AdderallPhentermine vs AdderallProzac vs AdderallQelbree vs AdderallRitalin vs AdderallVyvanse vs AdderallWakix vs Adderall
View More

Browse medications

View All

Research prescriptions and over-the-counter medications from A to Z, compare drug prices, and start saving.