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Sudafed vs. Phenylephrine

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Sudafed

(pseudoephedrine)

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phenylephrine eye drops

 

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Summary for Sudafed

Over-the-counter

Sudafed (pseudoephedrine) is a non-drowsy decongestant taken by mouth to treat nasal and sinus congestion from allergies and the common cold. It's available in a short-acting version that's taken once every 4 to 6 hours. It also comes in longer-acting versions that are taken every 12 or 24 hours, depending on the dose. Side effects of Sudafed (pseudoephedrine) include anxiety and headache. This medication might also keep you awake at night if you take it too close to bedtime. Sudafed (pseudoephedrine) is an OTC medication, but it's restricted, so you can only purchase it at the pharmacy counter.

Indications for Sudafed

  • Short-term relief of nasal and sinus congestion and pressure

Pros and Cons for Sudafed

Pros

  • Works well to treat congestion
  • Available in longer-acting versions that last 12 hours or 24 hours
  • Children's oral liquids can be taken by kids as young as 4 years old
  • Available as lower-cost generics

Cons

  • Several products have different age cut-offs for use in children, so can be confusing
  • Might make it hard for some people to sleep
  • Can raise blood pressure and heart rate
  • Not recommended during pregnancy

Common Side Effects for Sudafed

  • Sweating
  • Nervousness
  • Excitability
  • Difficulty sleeping
  • Low appetite
  • Difficulty urinating

Warnings for Sudafed

  • Fast heart rate and high blood pressure
  • Worsening of medical conditions
  • Accidental overdose

Summary for Phenylephrine

Prescription only

Phenylephrine eye drops are used to dilate (widen) pupils for eye exams or certain eye procedures. Side effects include temporary burning or stinging in the eye, blurry vision, and possibly raise your blood pressure. Let your provider know if your pregnant or breastfeeding because you might need to use a different medication.

Indications for Phenylephrine

  • Dilate (widen) pupils

Pros and Cons for Phenylephrine

Pros

  • Can be used in adults and children
  • Starts working quickly (within 15 minutes)
  • Available as a lower-cost generic medication

Cons

  • Can cause eye pain and stinging
  • Dilating effects can last for up to 7 hours (or longer)
  • The 10% strength can raise blood pressure in people with certain heart or thyroid problems

Common Side Effects for Phenylephrine

  • Temporary stinging or burning in your eye
  • Temporary blurry vision
  • Sensitivity to light

Warnings for Phenylephrine

  • For use in the eyes only
  • Heart problems
  • High blood pressure
  • Rebound pupil constriction

Prices with our coupons for Sudafed vs. Phenylephrine

Price Card Drug Icon
Pseudoephedrine24 tablets / 30mg
$10.68-
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Price Card Drug Icon
Phenylephrine1 eye dropper / 2ml of 2.5%
$21.67$40.99
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