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Compare Soliris vs. Ultomiris

Head-to-head comparisons of medication uses, side effects, warnings, and more.

  • Soliris (eculizumab)
    Ultomiris (ravulizumab)
  • Soliris (eculizumab)
    Ultomiris (ravulizumab)

  • Summary of Soliris vs. Ultomiris

    Summary for Complement inhibitor
    Prescription only

    Soliris (eculizumab) is used to treat certain nerve problems, such as myasthenia gravis. It can also help with rare blood problems, like paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome. This medication is a monoclonal antibody known as a complement inhibitor. It's given as an infusion through the vein by a healthcare professional. Side effects include headache, nausea, and high blood pressure. There's also a risk of serious meningococcal infection. So, it's only available through a special program called the Soliris Risk Evaluation and Mitigation Strategy (REMS). Currenly, Soliris (eculizumab) is a brand-name medication only.

    Summary for Complement inhibitor
    Prescription only

    Ultomiris (ravulizumab or ravulizumab-cwvz) is a type of monoclonal antibody called a complement inhibitor. This medication is used to treat adults and children with certain autoimmune conditions that affect the blood or nerves. It's given as an infusion through the veins (IV) once every 1 or 2 months. For certain adults, the medication can also be injected under the skin (subcutaneous) once per week. Side effects include upper respiratory tract infections and headache. Ultomiris (ravulizumab) is available only through the FDA’s Ultomiris REMS program because of the risk for serious meningococcal infections.

  • Indications of Soliris vs. Ultomiris

    Indications for
    •Paroxysmal nocturnal hemoglobinuria (PNH) in adults
    •Atypical hemolytic uremic syndrome (aHUS) in adults and children
    •Generalized myasthenia gravis (gMG)) in certain people who are 6 years and older
    •Neuromyelitis optica spectrum disorder (NMOSD)) in certain adults
    Indications for
    •Paroxysmal nocturnal hemoglobinuria (PNH) in adults and children ages 1 month and older
    •Atypical hemolytic uremic syndrome (aHUS) in adults and children ages 1 month and older
    •Generalized myasthenia gravis (gMG) in adults
    •Neuromyelitis optica spectrum disorder (NMOSD) in adults

  • Pros and Cons of Soliris vs. Ultomiris

    Pros and Const for Complement inhibitor
    Pros
    •Given every week or every 2 weeks for most people
    •Can be given to some children with aHUS or gMG
    •Monitored by a healthcare professional for safety during and a little while after each infusion
    Cons
    •Must be given as an infusion through the vein at a medical center
    •Need to get certain vaccines before starting treatment
    •Higher risk of serious infection
    Pros and Const for Complement inhibitor
    Pros
    •Can be given to adults and children 1 month of age and older (for PNH and aHUS)
    •IV infusions generally given every 1 or 2 months (except for first few doses)
    •Adults with certain autoimmune conditions have option of weekly, under-the-skin injections at home
    Cons
    •Appointments for IV infusion can last a few hours
    •Raises the risk of serious infection
    •Might need to follow up with your healthcare team even after you stop treatment because of risk for complications

  • Common Side Effects of Soliris vs. Ultomiris

    Common Side Effects for

    PNH:

    •Headache (44%)
    •Cold-like symptoms (23%)
    •Back pain (19%)
    •Nausea (16%)
    •Tiredness (12%)
    •Cough (12%)

    aHUS:

    •Headache (41%)
    •Diarrhea (37%)
    •Vomiting (30%)
    •High blood pressure (33%)
    •Cold-like symptoms (27%)
    •Anemia (26%)
    •Nausea (23%)
    •Swelling in the arms or legs (23%)
    •Cough (23%)
    •Urinary tract infection (22%)
    •Fever (21%)

    gMG:

    •Headache (26%)
    •Cold-like symptoms (24%)
    •Diarrhea (15%)
    •Joint pain (12%)
    •Upper respiratory tract infection (11%)
    •Nausea (10%)

    NMOSD:

    •Upper respiratory tract infection (29%)
    •Cold-like symptoms (21%)
    •Diarrhea (16%)
    •Dizziness (15%)
    •Back pain (15%)
    •Joint pain (11%)
    •Flu (11%)
    •Sore throat (10%)
    •Bruising (10%)
    Common Side Effects for

    PNH: Note: Side effects reported by adults with PNH getting IV infusions of Ultomiris (ravulizumab)

    •Upper respiratory tract infection (39%)
    •Headache (32%)

    aHUS:

    •Headache (40%)
    •Diarrhea (31%)
    •Nausea (26%)
    •Vomiting (26%)
    •Upper respiratory tract infection (26%)
    •High blood pressure (24%)
    •Joint pain (22%)
    •Fever (19%)
    •Cough (17%)
    •Shortness of breath (17%)
    •Swelling in arms or legs (17%)
    •Urinary tract infection (17%)

    gMG:

    •Diarrhea (15%)
    •Upper respiratory tract infection (14%)

    NMOSD:

    •COVID-19 infection (24%)
    •Headache (24%)
    •Back pain (12%)
    •Joint pain (10%)
    •Urinary tract infection (10%)

  • Warnings of Soliris vs. Ultomiris

    Common Side Effects for
    •Risk of serious meningococcal infections
    •Risk of other serious infections
    •Worsening of PNH after stopping treatment
    •Worsening of aHUS after stopping treatment
    •Infusion reactions
    Common Side Effects for
    •Serious infections (especially meningococcal infections)
    •Problems that happen after you stop treatment - for people with PNH or aHUS only
    •Infusion-related reactions and allergic reactions
    •Allergy to acrylic adhesives - for Ultomiris (ravulizumab) on-body injector only

  • Prices with our coupons for Soliris vs. Ultomiris

    Learn more about Soliris
    Learn more about Ultomiris

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