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Compare Sertraline vs. Amoxapine

Head-to-head comparisons of medication uses, side effects, warnings, and more.

  • Sertraline (Zoloft)
    Amoxapine
  • Sertraline (Zoloft)
    Amoxapine

  • Summary of Sertraline vs. Amoxapine

    Summary for SSRI
    Prescription only

    Sertraline (Zoloft) is a selective serotonin reuptake inhibitor (SSRI). It's used to treat different mental health conditions, including depression and certain types of anxiety disorder, such as panic disorder. It's typically taken by mouth once per day. This medication is available as both a tablet and liquid. Common side effects of sertraline (Zoloft) include nausea, diarrhea, and dry mouth. It's best to avoid alcohol while taking sertraline (Zoloft) because this combination can worsen side effects of sertraline (Zoloft).

    Summary for Tricyclic antidepressant
    Prescription only

    Amoxapine is an antidepressant that's used for people who have both depression and anxiety. But, it's not a first-choice option because it has a higher risk of side effects. Drowsiness, dry mouth, constipation, and blurry vision are the most common side effects of amoxapine. The brand name Asendin is no longer sold in the United States, but it's still available as a lower-cost generic tablet.

  • Indications of Sertraline vs. Amoxapine

    Indications for
    •Major depressive disorder (MDD)
    •Obsessive-compulsive disorder (OCD)
    •Panic disorder (PD)
    •Post-traumatic stress disorder (PTSD)
    •Premenstrual dysphoric disorder (PMDD)
    •Social anxiety disorder (SAD)
    Indications for
    •Depression that comes along with anxiety or agitation

  • Pros and Cons of Sertraline vs. Amoxapine

    Pros and Const for SSRI
    Pros
    •Taken by mouth once daily
    •A possible option during pregnancy and breastfeeding
    •Fewer interactions compared to other SSRIs
    •Less likely to cause weight gain compared to paroxetine (Paxil)
    •Available as a generic
    Cons
    •Can take up to 2 months before you feel the full benefits
    •More likely to cause diarrhea compared to other SSRIs
    •Might make it more difficult for you to fall asleep
    •Can cause withdrawal symptoms if you suddenly stop taking it
    •The liquid form contains alcohol
    Pros and Const for Tricyclic antidepressant
    Pros
    •Doses up to 300 mg can be taken once a day.
    •Might work faster than similar medications like amitriptyline or imipramine
    •Available as a lower-cost generic
    Cons
    •Causes a lot of side effects
    •Higher risk of side effects in older adults
    •Not a good option for people with a history of seizures

  • Common Side Effects of Sertraline vs. Amoxapine

    Common Side Effects for
    •Nausea (26%)
    •Diarrhea (20%)
    •Difficulty sleeping (20%)
    •Dry mouth (14%)
    •Sleepiness (12%)
    Common Side Effects for
    •Drowsiness (14%)
    •Dry mouth (14%)
    •Constipation (12%)
    •Blurred vision (7%)

  • Warnings of Sertraline vs. Amoxapine

    Common Side Effects for
    •Worsening depression, suicidal thoughts, and unusual behavior
    •Serotonin syndrome
    •Risk of bleeding
    •Not for use alone in bipolar disorder
    •Glaucoma
    •Life-threatening abnormal heart rhythm (QT prolongation)
    •Low blood sodium levels
    Common Side Effects for
    •Suicidal thoughts and behavior
    •Possible bipolar disorder
    •Eye problems
    •Difficulty controlling movements
    •Neuroleptic malignant syndrome

  • Prices with our coupons for Sertraline vs. Amoxapine

    Learn more about Sertraline
    Learn more about Amoxapine

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