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Sertraline vs. Amoxapine

Sertraline (Zoloft) is a selective serotonin reuptake inhibitor (SSRI). It's used to treat different mental health conditions, including depression and certain types of anxiety disorder, such as panic disorder. It's typically taken by mouth once per day. This medication is available as both a tablet and liquid. Common side effects of sertraline (Zoloft) include nausea, diarrhea, and dry mouth. It's best to avoid alcohol while taking sertraline (Zoloft) because this combination can worsen side effects of sertraline (Zoloft).

• Major depressive disorder (MDD)
• Obsessive-compulsive disorder (OCD)
• Panic disorder (PD)
• Post-traumatic stress disorder (PTSD)
• Premenstrual dysphoric disorder (PMDD)
• Social anxiety disorder (SAD)

• Nausea (26%)
• Diarrhea (20%)
• Difficulty sleeping (20%)
• Dry mouth (14%)
• Sleepiness (12%)

• Worsening depression, suicidal thoughts, and unusual behavior
• Serotonin syndrome
• Risk of bleeding
• Not for use alone in bipolar disorder
• Glaucoma
• Life-threatening abnormal heart rhythm (QT prolongation)
• Low blood sodium levels

Amoxapine is an antidepressant that's used for people who have both depression and anxiety. But, it's not a first-choice option because it has a higher risk of side effects. Drowsiness, dry mouth, constipation, and blurry vision are the most common side effects of amoxapine. The brand name Asendin is no longer sold in the United States, but it's still available as a lower-cost generic tablet.

• Depression that comes along with anxiety or agitation

• Drowsiness (14%)
• Dry mouth (14%)
• Constipation (12%)
• Blurred vision (7%)

• Suicidal thoughts and behavior
• Possible bipolar disorder
• Eye problems
• Difficulty controlling movements
• Neuroleptic malignant syndrome