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Penicillin vs. Bactrim

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Sulfamethoxazole/trimethoprim (Bactrim) and penicillin v potassium (Penicillin VK) are antibiotics used to treat bacterial infections but differ in their classes and applications. Bactrim, a sulfonamide antibiotic combining sulfamethoxazole and trimethoprim, is effective for urinary tract infections, ear infections, and traveler's diarrhea. It is available in tablet, liquid, and injection forms but is not suitable for those with a sulfa allergy or pregnant women. Common side effects include nausea, vomiting, and diarrhea. Penicillin VK, a penicillin antibiotic, is primarily used for strep infections and some pneumococcal and staph infections. It is available as a generic in tablet and suspension forms and has fewer side effects, such as nausea and diarrhea. However, many bacteria are resistant to it, and it is not recommended for those allergic to penicillin or cephalosporins. Both medications require completing the full course to prevent bacterial resistance.

Penicillin V potassium

(Penicillin VK)

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Sulfamethoxazole/trimethoprim

 

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Summary for Penicillin

Prescription only

Penicillin V potassium (Penicillin VK) is an antibiotic used to treat several types of infections throughout the body in adults and children. It's available as tablets and suspension that are taken by mouth. The dosage depends on the type of infection you have and how severe it is, but the medication is typically taken every 6 to 12 hours. Side effects include nausea, diarrhea, and vomiting.

Indications for Penicillin

Pros and Cons for Penicillin

Pros

  • Works well to treat many different bacterial infections
  • Can use for adults and children
  • Can be taken with or without food
  • Available as a tablet and suspension

Cons

  • Can cause stomach side effects like nausea, vomiting, and diarrhea
  • Might not be able to take this medication if you've had a severe allergy to penicillin
  • Not recommended for treating a cold or the flu because these are viral infections
  • Needs to be taken every 6 to 8 hours

Common Side Effects for Penicillin

  • Nausea
  • Vomiting
  • Stomach upset
  • Diarrhea

Warnings for Penicillin

  • Allergic reaction
  • Infectious diarrhea
  • Development of drug-resistant bacteria

Summary for Bactrim

Prescription only

Sulfamethoxazole/trimethoprim (sometimes known as SMZ/TMP) is a combination medication containing an antifolate and sulfa antibiotic. It's used to treat different types of infections, such as urinary tract infections (UTIs), ear infections, and lung infections. This antibiotic has two different brand names, Bactrim and Septra, and it's also available as a lower-cost generic. It's a tablet that's taken by mouth, typically twice daily for most types of infections. This antibiotic also comes as a suspension under the brand name Sulfatrim for people who can't swallow tablets and as an injection for people in the hospital. Common side effects include nausea, diarrhea, and rash.

Indications for Bactrim

Pros and Cons for Bactrim

Pros

  • Treats many types of bacterial infections
  • Can be given to children as young as 2 months old to treat certain infections
  • Available as a lower-cost generic

Cons

  • Can upset your stomach and make your skin more sensitive to the sun
  • Not the best choice for people with liver or kidney problems
  • Not recommended if you're pregnant
  • Can't take if you have a sulfa allergy

Common Side Effects for Bactrim

Warnings for Bactrim

  • Not for use during pregnancy
  • Severe allergic reactions and skin reactions
  • Low platelet counts and risk for bleeding
  • Diarrhea from Clostridioides difficile infection
  • Low sodium levels and high potassium levels
  • Blood cell-related problems
  • Problems with processing phenylalanine - for people with phenylketonuria (PKU) only

Prices with our coupons for Penicillin vs. Bactrim

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Penicillin V Potassium28 tablets / 500mg
$13.97-
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Sulfamethoxazole/Trimethoprim14 tablets / 800mg/160mg
$8.90$10.89
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