Otulfi vs. Stelara for Plaque Psoriasis and Ulcerative Colitis: Important Differences and Potential Risks.

Otulfi

(ustekinumab)

Stelara

(ustekinumab)

Summary for Otulfi

Prescription only

Otulfi (ustekinumab or ustekinumab-aauz) is a biologic medication and a biosimilar to Stelara (ustekinumab). Like Stelara (ustekinumab), it's FDA approved to treat several autoimmune conditions, such as plaque psoriasis, psoriatic arthritis, Crohn's disease, and ulcerative colitis. It works by lowering inflammation through blocking proteins in the body called interleukins. The medication is typically given as an injection under the skin, with doses spaced every 8 to 12 weeks based on your condition. Common side effects include tiredness, headache, and cold-like symptoms.

Indications for Otulfi

Moderate-to-severe plaque psoriasis (Ps) - adults and children 6 years and older
Psoriatic arthritis (PsA) - adults and children 6 years and older
Moderate-to-severe Crohn's disease (CD) - adults only
Moderate-to-severe ulcerative colitis (UC) - adults only

Pros and Cons for Otulfi

Pros

Biosimilar that's interchangeable with Stelara (ustekinumab)
Syringes can be stored at room temperature for up to 30 days
Approved for children as young as 6 years old for certain conditions
Stopper isn't made of natural rubber latex

Cons

Can weaken your immune system and raise your risk of infection
Potential to cause serious allergic reactions
For CD and UC, the first dose must be given as an IV infusion
Can't receive live vaccines while taking this medication

Common Side Effects for Otulfi

Plaque psoriasis

Common cold symptoms (7-8%)
Upper respiratory tract infection (4-5%)
Headache (5%)

Psoriatic arthritis

Joint pain (3%)
Nausea (3%)

Crohn's disease

Common cold symptoms (11%)
Redness at the injection site (5%)
Yeast infection (5%)
Bronchitis (5%)

Ulcerative colitis:

Common cold symptoms (24%)
Headache (10%)
Stomach pain (7%)
Flu infection (6%)
Fever (5%)

Warnings for Otulfi

Infections
Cancers
Severe allergic reaction
Brain condition
Vaccines
Lung problems

Summary for Stelara

Prescription only

Stelara (ustekinumab) is an injectable medication used to treat autoimmune conditions like plaque psoriasis, psoriatic arthritis, Crohn's disease, and ulcerative colitis. As an interleukin antagonist, it works by blocking certain proteins that cause inflammation in your body, which helps reduce swelling and ease symptoms. You typically get it as an injection under your skin. Common side effects include common cold symptoms, headache, and feeling tired. This medication also has many biosimilars available.

Indications for Stelara

Moderate-to-severe plaque psoriasis (Ps) - adults and children 6 years and older
Psoriatic arthritis (PsA) - adults and children 6 years and older
Moderate-to-severe Crohn's disease (CD) - adults only
Moderate-to-severe ulcerative colitis (UC) - adults only

Pros and Cons for Stelara

Pros

After the first few doses, only need a shot every 8 to 12 weeks
Available as a prefilled syringe or vial
Syringes can be stored at room temperature for up to 30 days
Approved for children as young as 6 years old

Cons

Can weaken your immune system and raise your risk of infection
Potential to cause serious allergic reactions
For CD and UC, the first dose must be given as an IV infusion
Can't receive live vaccines while taking this medication

Common Side Effects for Stelara

Plaque psoriasis

Common cold symptoms (7-8%)
Upper respiratory tract infection (4-5%)
Headache (5%)

Psoriatic arthritis

Joint pain (3%)
Nausea (3%)

Crohn's disease

Common cold symptoms (11%)
Redness at the injection site (5%)
Yeast infection (5%)
Bronchitis (5%)

Ulcerative colitis:

Common cold symptoms (24%)
Headache (10%)
Stomach pain (7%)
Flu infection (6%)
Fever (5%)

Warnings for Stelara

Infections
Cancers
Severe allergic reaction
Brain condition
Vaccines
Lung problems

Prices with our coupons for Otulfi vs. Stelara

Otulfi1 syringe / 1ml of 90mg/ml

$3,481.03-

Get free coupons

More Information

Ustekinumab1 syringe / 1ml of 90mg/ml

$7,002.73$10,599.65

Get free coupons

More Information

Browse medications by letter

Show All

Browse prescription and over-the-counter medications from A to Z, compare drug prices, and start saving.

Compare
Otulfi vs. Stelara

Otulfi

Stelara

Summary for Otulfi

Indications for Otulfi

Pros and Cons for Otulfi

Pros

Cons

Common Side Effects for Otulfi

Warnings for Otulfi

Summary for Stelara

Indications for Stelara

Pros and Cons for Stelara

Pros

Cons

Common Side Effects for Stelara

Warnings for Stelara

Prices with our coupons for Otulfi vs. Stelara

Browse medications by letter

Good news for your inbox

Otulfi

Stelara

Summary for Otulfi

Indications for Otulfi

Pros and Cons for Otulfi

Pros

Cons

Common Side Effects for Otulfi

Warnings for Otulfi

Summary for Stelara

Indications for Stelara

Pros and Cons for Stelara

Pros

Cons

Common Side Effects for Stelara

Warnings for Stelara