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Onyda XR vs. Kapvay

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Onyda XR

(clonidine)

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Clonidine ER

(Kapvay)

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Summary for Onyda XR

Prescription only

Onyda XR (clonidine) is a non‑stimulant medication for attention-deficit hyperactivity disorder (ADHD). It's FDA approved for children 6 years and older. It can be used by itself or with stimulant ADHD medications. Onyda XR (clonidine) is an extended‑release liquid you take by mouth once each night at bedtime. Common effects include sleepiness, tiredness, and headache. Onyda XR (clonidine) can also lower blood pressure and slow the heart rate, so your care team might check these regularly.

Indications for Onyda XR

Pros and Cons for Onyda XR

Pros

  • Non‑stimulant option for ADHD
  • Taken once at night, so it could be a good option for people with busy morning routines
  • Is a liquid, so it's an option for children who can't swallow pills
  • Can be used alone or with a stimulant ADHD medication

Cons

Common Side Effects for Onyda XR

  • Drowsiness (31%–38%)
  • Headache (13%–20%)
  • Feeling tired (13%–16%)
  • Upper stomach pain (10%–15%)
  • Irritability (5%–9%)
  • Dizziness (3%–7%)
  • Trouble sleeping (5%–6%)
  • Constipation (1%–6%)
  • Nausea (4-5%)

Warnings for Onyda XR

  • Low blood pressure and slow heart rate
  • Possible heart rhythm problems
  • Sleepiness and dizziness
  • Dangerously high blood pressure after stopping Onyda XR (clonidine) suddenly
  • Allergic reaction

Summary for Kapvay

Prescription only

Extended-release clonidine (Kapvay) is an alpha-2 agonist. It's a non-stimulant medication used to treat attention deficit-hyperactivity disorder (ADHD) in adults and children. Clonidine ER (Kapvay) is taken by mouth, typically twice per day. Some of the more common side effects include sleepiness and headache. This medication rarely causes insomnia (trouble sleeping), and isn't known to cause weight gain. Brand name Kapvay has been discontinued; clonidine ER (Kapvay) is only available as a generic medication.

Indications for Kapvay

Pros and Cons for Kapvay

Pros

Cons

  • Not a first-choice option for ADHD
  • Need to take twice daily
  • Can cause withdrawal symptoms if stopped suddenly

Common Side Effects for Kapvay

  • Sleepiness (up to 38%)
  • Headache (up to 20%)
  • Fatigue (up to 16%)
  • Upper stomach pain (up to 15%)

Warnings for Kapvay

  • Blood pressure, heart rate, and heart rhythm problems
  • Extreme sleepiness and dizziness
  • Allergic reaction

Prices with our coupons for Onyda XR vs. Kapvay

Price Card Drug Icon
Onyda XR1 bottle / 30ml of 0.1mg/ml
$398.33$505.06
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Clonidine ER60 tablets / 0.1mg
$29.10$250.99
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