Nuzyra
(omadacycline)
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Summary for Nuzyra
Nuzyra (omadacycline) is a tetracycline antibiotic that's used to treat community-acquired bacterial pneumonia and skin infections in adults. It's available as a tablet taken by mouth and an injection into the veins (IV). On the first day of treatment, Nuzyra (omadacycline) might be given twice during the day. After that, it's taken once per day until treatment is complete. Side effects can include nausea and vomiting. Nuzyra (omadacycline) is currently available as a brand-name medication only.
Indications for Nuzyra
- Community-acquired pneumonia
- Skin infections (e.g., cellulitis)
Pros and Cons for Nuzyra
Pros
- Works against a wide range of bacteria, including some resistant bacteria
- Taken once a day (after the first day of treatment)
- Safe for people who have kidney or liver problems
Cons
- Need take the tablets on an empty stomach (requires specific timing)
- Not safe for use in children, during pregnancy, or while breastfeeding
- No lower-cost generic available; a brand-name medication only
Common Side Effects for Nuzyra
- Nausea (22%)
- Vomiting (11%)
- Elevated liver enzyme levels (up to 4%)
Warnings for Nuzyra
- More reported deaths in studies when treating pneumonia
- Color changes to the teeth
- Slower growth in children
- Allergic reaction
- Severe infectious diarrhea (called C. diff-associated diarrhea or CDAD)
- Side effects related to tetracycline antibiotics
- Drug-resistant bacteria
Summary for Vibramycin
Doxycycline hyclate is an antibiotic that treats many conditions, including acne, chlamydia, sinus infection, and urinary tract infection (UTI). It's taken by mouth, typically once or twice daily. It comes as capsules, tablets, and a liquid syrup. Side effects of doxycycline hyclate include stomach upset, nausea, and vomiting.
Indications for Vibramycin
Doxycycline hyclate is used to prevent malaria due to the parasite Plasmodium falciparum and to treat many different infections caused by bacteria. Some examples include:
- Respiratory tract infections, including in the nose, throat, and lungs
- Infections caused by ticks, mites, or fleas (Rocky Mountain spotted fever or typhus fever)
- Sexually-transmitted infections (STIs) like chlamydia, gonorrhea, chancroid, and syphilis
- Lyme disease
- Urinary tract infections (UTIs)
- Severe acne
- Anthrax
- Plague
- Cholera
Pros and Cons for Vibramycin
Pros
- Good alternative for some infections if you're allergic to penicillins
- Treats many different infections, including severe acne and sexually transmitted infections (STIs) like chlamydia
- Available as a liquid for those who have trouble swallowing pills
- Likely safe for people who have kidney problems
Cons
- Can raise your risk of sunburns
- Can sometimes cause stomach discomfort or stomach upset
- Interacts with blood thinners and birth control pills
- Not safe for young children or pregnant females
Common Side Effects for Vibramycin
- Stomach upset
- Nausea
- Vomiting
- Loss of appetite
- Sunburn
Warnings for Vibramycin
- Permanent tooth discoloration
- Severe diarrhea
- Severe skin reactions
- High pressure in the brain (intracranial hypertension or pseudotumor cerebri)
- Harm to unborn and young babies
- Sunburn
- Damage to the esophagus
- New infections
- Drug-resistant bacteria
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