Myfembree
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Orilissa
(elagolix)
Get free couponsSummary for Myfembree
Myfembree is a combination medication containing relugolix, estradiol, and norethindrone. It's used to manage heavy menstrual bleeding related to uterine fibroids. This medication can also help relieve pain from endometriosis. Myfembree is approved for use in women who haven't reached menopause and is a tablet that's taken once daily. Common Myfembree side effects include hot flashes and headaches.
Indications for Myfembree
- Heavy menstrual bleeding related to uterine fibroids in women who haven't reached menopause
- Moderate-to-severe pain related to endometriosis in women who haven't reached menopause
Pros and Cons for Myfembree
Pros
- Only taken once a day
- Can also provide relief from pain and symptoms related to uterine fibroids like pelvic pressure or discomfort
- Can relieve different types of pain from endometriosis (e.g., pain during your menstrual period, pelvic pain unrelated to your period)
Cons
- Might have irregular menstrual bleeding patterns
- Can raise the risk of blood clots, heart attacks, or strokes
- Recommended to take for a maximum of 2 years because of the risk for bone loss
Common Side Effects for Myfembree
Uterine fibroids:
- Hot flashes, a lot of sweating, or night sweats (11%)
- New or worsening high blood pressure (7%)
- Unusual or irregular vaginal bleeding (6%)
- Hair loss or hair thinning (4%)
Endometriosis:
- Headache (33%)
- Hot flashes, a lot of sweating, or night sweats (13%)
- Mood problems or mood swings (9%)
- Unusual vaginal bleeding (7%)
- Nausea (6%)
Warnings for Myfembree
- Blood clots, heart attacks, and strokes
- Bone loss
- Can't take if you have certain hormone-sensitive cancers
- Change in menstrual bleeding patterns
- Not able to recognize pregnancy and risk of early pregnancy loss
- Depression, mood changes, and suicidal behavior
- Liver or gallbladder problems
- Risk of your fibroid coming out into the vagina
- Changes to certain lab test results
Summary for Orilissa
Orilissa (elagolix) is a hormone-free medication used to help manage moderate or severe pain caused by endometriosis in adults. It belongs to a drug class called gonadotropin-releasing hormone (GnRH) antagonists. Orilissa (elagolix) comes as a tablet that's taken by mouth. It's taken once or twice a day, depending on other health conditions you have. Common side effects include hot flashes and headaches.
Indications for Orilissa
- Moderate-to-severe pain caused by endometriosis
Pros and Cons for Orilissa
Pros
- Helps reduce pain due to endometriosis
- Doesn't contain hormones
- Taken once a day (or twice a day if you have pain during sex)
Cons
- Might not feel less pain right away (can take a month or longer)
- Taken for a set amount of time because of bone loss risk with long-term use
- Can cause hot flashes and change menstrual bleeding patterns
Common Side Effects for Orilissa
- Hot flash (24-46%)
- Headache (17-20%)
- Nausea (11-16%)
- Trouble sleeping (6-9%)
- Missing a menstrual period (4-7%)
- Mood swings (5-6%)
- Depressed mood (3-6%)
Warnings for Orilissa
- Bone loss
- Change in menstrual bleeding pattern and effect on recognizing pregnancy
- Suicidal thoughts or behavior or worsened mood problems
- Liver damage
- Interactions with hormonal birth control
- Risk of harm to an unborn baby
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