Myfembree vs. Orilissa for Endometriosis: Important Differences and Potential Risks.

Myfembree

Orilissa

(elagolix)

Summary for Myfembree

Prescription only

Myfembree is a combination medication containing relugolix, estradiol, and norethindrone. It's used to manage heavy menstrual bleeding related to uterine fibroids. This medication can also help relieve pain from endometriosis. Myfembree is approved for use in women who haven't reached menopause and is a tablet that's taken once daily. Common Myfembree side effects include hot flashes and headaches.

Indications for Myfembree

Heavy menstrual bleeding related to uterine fibroids in women who haven't reached menopause
Moderate-to-severe pain related to endometriosis in women who haven't reached menopause

Pros and Cons for Myfembree

Pros

Only taken once a day
Can also provide relief from pain and symptoms related to uterine fibroids like pelvic pressure or discomfort
Can relieve different types of pain from endometriosis (e.g., pain during your menstrual period, pelvic pain unrelated to your period)

Cons

Might have irregular menstrual bleeding patterns
Can raise the risk of blood clots, heart attacks, or strokes
Recommended to take for a maximum of 2 years because of the risk for bone loss

Common Side Effects for Myfembree

Uterine fibroids:

Hot flashes, a lot of sweating, or night sweats (11%)
New or worsening high blood pressure (7%)
Unusual or irregular vaginal bleeding (6%)
Hair loss or hair thinning (4%)

Endometriosis:

Headache (33%)
Hot flashes, a lot of sweating, or night sweats (13%)
Mood problems or mood swings (9%)
Unusual vaginal bleeding (7%)
Nausea (6%)

Warnings for Myfembree

Blood clots, heart attacks, and strokes
Bone loss
Can't take if you have certain hormone-sensitive cancers
Change in menstrual bleeding patterns
Not able to recognize pregnancy and risk of early pregnancy loss
Depression, mood changes, and suicidal behavior
Liver or gallbladder problems
Risk of your fibroid coming out into the vagina
Changes to certain lab test results

Summary for Orilissa

Prescription only

Orilissa (elagolix) is a hormone-free medication used to help manage moderate or severe pain caused by endometriosis in adults. It belongs to a drug class called gonadotropin-releasing hormone (GnRH) antagonists. Orilissa (elagolix) comes as a tablet that's taken by mouth. It's taken once or twice a day, depending on other health conditions you have. Common side effects include hot flashes and headaches.

Indications for Orilissa

Moderate-to-severe pain caused by endometriosis

Pros and Cons for Orilissa

Pros

Helps reduce pain due to endometriosis
Doesn't contain hormones
Taken once a day (or twice a day if you have pain during sex)

Cons

Might not feel less pain right away (can take a month or longer)
Taken for a set amount of time because of bone loss risk with long-term use
Can cause hot flashes and change menstrual bleeding patterns

Common Side Effects for Orilissa

Hot flash (24-46%)
Headache (17-20%)
Nausea (11-16%)
Trouble sleeping (6-9%)
Missing a menstrual period (4-7%)
Mood swings (5-6%)
Depressed mood (3-6%)

Warnings for Orilissa

Bone loss
Change in menstrual bleeding pattern and effect on recognizing pregnancy
Suicidal thoughts or behavior or worsened mood problems
Liver damage
Interactions with hormonal birth control
Risk of harm to an unborn baby

Prices with our coupons for Myfembree vs. Orilissa

Myfembree28 tablets / 40mg/1mg/0.5mg

$1,276.39$1,655.57

Get free coupons

More Information

Orilissa1 dose pack / 28 tablets of 150mg

$1,232.38$1,589.72

Get free coupons

More Information

Compare other Endometriosis drugs

Orilissa vs. Myfembree Clomiphene vs. Leuprolide Leuprolide vs. Orilissa

Browse medications by letter

Show All

Browse prescription and over-the-counter medications from A to Z, compare drug prices, and start saving.

Compare
Myfembree vs. Orilissa

Myfembree

Orilissa

Summary for Myfembree

Indications for Myfembree

Pros and Cons for Myfembree

Pros

Cons

Common Side Effects for Myfembree

Warnings for Myfembree

Summary for Orilissa

Indications for Orilissa

Pros and Cons for Orilissa

Pros

Cons

Common Side Effects for Orilissa

Warnings for Orilissa

Prices with our coupons for Myfembree vs. Orilissa

Compare other Endometriosis drugs

Browse medications by letter

Good news for your inbox

Myfembree

Orilissa

Summary for Myfembree

Indications for Myfembree

Pros and Cons for Myfembree

Pros

Cons

Common Side Effects for Myfembree

Warnings for Myfembree

Summary for Orilissa

Indications for Orilissa

Pros and Cons for Orilissa

Pros

Cons

Common Side Effects for Orilissa

Warnings for Orilissa