Key takeaways
Mucinex DM (guaifenesin/dextromethorphan) and Delsym (dextromethorphan) are both over-the-counter medications used to relieve cough caused by minor throat or lung irritation, such as the common cold. They both contain dextromethorphan, a cough suppressant. However, Mucinex DM also includes guaifenesin, an expectorant that helps loosen mucus in the airways, making it easier to cough out. Mucinex DM is available in tablets, oral liquid, and dissolvable granules, while Delsym is available as an extended-release syrup and immediate-release caplets. Mucinex DM is typically taken every 4 to 12 hours depending on the formulation, whereas Delsym is taken every 6 to 12 hours, depending on the formulation. Both medications can cause drowsiness and stomach upset. Do not take either medication with other products containing dextromethorphan.
