Jynarque vs. Samsca for Kidney Disease and Hyponatremia: Important Differences and Potential Risks.

Jynarque

(tolvaptan)

Tolvaptan

(Samsca)

Summary for Jynarque

Prescription only

Jynarque (tolvaptan) helps protect kidney function in adults with autosomal dominant polycystic kidney disease (ADPKD) who are at risk of their condition getting worse quickly. It works as a vasopressin-2 (V2) receptor antagonist. Jynarque (tolvaptan) comes as a tablet that's taken by mouth twice a day (8 hours apart). At the start, your dose is slowly raised based on how you respond. Common side effects include feeling thirsty and needing to urinate more often. It can also cause serious liver damage. Because of this risk, it's only available through a special Risk Evaluation and Mitigation Strategy (REMS) program.

Indications for Jynarque

Protect kidney function in adults with autosomal dominant polycystic kidney disease (ADPKD) who are at risk of their condition worsening quickly

Pros and Cons for Jynarque

Pros

The only FDA-approved treatment that helps slow the loss of kidney function in people with ADPKD
Comes as a tablet that's taken by mouth
Can take with or without food

Cons

Must take twice a day with specific timing (taken 8 hours apart)
Can make you urinate more often and also feel very thirsty
Need to get blood work done regularly to check your liver for safety

Common Side Effects for Jynarque

More frequent urination (70%)
Feeling very thirsty (64%)
Dry mouth (16%)
Tiredness (14%)
Diarrhea (13%)
Dizziness (11%)
Indigestion (8%)
Lower appetite (7%)

Warnings for Jynarque

Liver damage
High sodium levels, dehydration, and low blood volume
Interactions with other medications

Summary for Samsca

Prescription only

Tolvaptan (Samsca) is used to treat hyponatremia (low blood sodium levels) caused by certain medical conditions. It's available as brand name and generic tablets, and it's taken by mouth once a day. You'll need to be monitored in the hospital when you first start the medication so your provider can check that your sodium levels aren't rising too quickly. Common side effects of tolvaptan (Samsca) include feeling thirsty, dry mouth, and needing to urinate more often.

Indications for Samsca

Low blood sodium levels with a high blood volume (hypervolemic hyponatremia)
Low blood sodium levels with a normal blood volume (euvolemic hyponatremia)

Pros and Cons for Samsca

Pros

Taken by mouth once per day
Can be taken with or without food (but avoid grapefruit juice)
Available as a lower-cost generic

Cons

Can cause you to urinate more often
Can cause serious liver problems
Must be started in the hospital

Common Side Effects for Samsca

Feeling thirsty (16%)
Dry mouth (13%)
Urinating more often and more volume (11%)
Lack of energy (9%)
Constipation (7%)
High blood sugar (6%)

Warnings for Samsca

Too rapid correction of blood sodium levels
Liver problems and liver failure
Dehydration and losing too much body fluid
Interactions with other medications
High blood potassium levels
Trouble with urination

Prices with our coupons for Jynarque vs. Samsca

Tolvaptan (Jynarque)60 tablets / 15mg

$16,848.30-

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Tolvaptan (Samsca)10 tablets / 15mg

$281.70-

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Jynarque vs. Samsca

Jynarque

Tolvaptan

Summary for Jynarque

Indications for Jynarque

Pros and Cons for Jynarque

Pros

Cons

Common Side Effects for Jynarque

Warnings for Jynarque

Summary for Samsca

Indications for Samsca

Pros and Cons for Samsca

Pros

Cons

Common Side Effects for Samsca

Warnings for Samsca

Prices with our coupons for Jynarque vs. Samsca

Browse medications by letter

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Jynarque

Tolvaptan

Summary for Jynarque

Indications for Jynarque

Pros and Cons for Jynarque

Pros

Cons

Common Side Effects for Jynarque

Warnings for Jynarque

Summary for Samsca

Indications for Samsca

Pros and Cons for Samsca

Pros

Cons

Common Side Effects for Samsca

Warnings for Samsca