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Compare Jynarque vs. Samsca

Head-to-head comparisons of medication uses, side effects, warnings, and more.

  • Jynarque (tolvaptan)
    Tolvaptan (Samsca)
  • Jynarque (tolvaptan)
    Tolvaptan (Samsca)

  • Summary of Jynarque vs. Samsca

    Summary for Vasopressin receptor antagonist, V2
    Prescription only

    Jynarque (tolvaptan) is a vasopressin-2 (V2) receptor antagonist that helps protect kidney function in adults with autosomal dominant polycystic kidney disease (ADPKD) who are at risk of their condition worsening quickly. It comes as a tablet that's taken by mouth twice a day, with doses spaced 8 hours apart. Treatment starts with a low dose and is slowly raised based on how you respond. Common side effects include feeling thirsty and needing to urinate often. Because this medication can cause serious liver damage, it's only available through a Risk Evaluation and Mitigation Strategy (REMS) program to make sure it's used safely.

    Summary for Vasopressin receptor antagonist, V2
    Prescription only

    Tolvaptan (Samsca) is used to treat hyponatremia (low blood sodium levels) caused by certain medical conditions. It's available as brand name and generic tablets, and it's taken by mouth once a day. You'll need to be monitored in the hospital when you first start the medication so your provider can check that your sodium levels aren't rising too quickly. Common side effects of tolvaptan (Samsca) include feeling thirsty, dry mouth, and needing to urinate more often.

  • Indications of Jynarque vs. Samsca

    Indications for
    •Protect kidney function in people with autosomal dominant polycystic kidney disease (ADPKD) at risk of their condition worsening quickly
    Indications for
    •Low blood sodium levels with a high blood volume (hypervolemic hyponatremia)
    •Low blood sodium levels with a normal blood volume (euvolemic hyponatremia)

  • Pros and Cons of Jynarque vs. Samsca

    Pros and Const for Vasopressin receptor antagonist, V2
    Pros
    •The only FDA-approved ADPKD treatment option to slow kidney function decline
    •Comes as a tablet that's taken by mouth
    •Can be taken with or without food
    Cons
    •Must be taken twice a day
    •Can make you urinate more often
    •Need to get blood work done regularly to check your liver
    Pros and Const for Vasopressin receptor antagonist, V2
    Pros
    •Taken by mouth once per day
    •Can be taken with or without food (but avoid grapefruit juice)
    •Available as a lower-cost generic
    Cons
    •Can cause you to urinate more often
    •Can cause serious liver problems
    •Must be started in the hospital

  • Common Side Effects of Jynarque vs. Samsca

    Common Side Effects for
    •Frequent urination (70%)
    •Feeling very thirsty (64%)
    •Dry mouth (16%)
    •Tiredness (14%)
    •Diarrhea (13%)
    •Dizziness (11%)
    •Indigestion (8%)
    •Poor appetite (7%)
    •Feeling bloated (5%)
    •Dry skin (5%)
    Common Side Effects for
    •Feeling thirsty (16%)
    •Dry mouth (13%)
    •Urinating more often and more volume (11%)
    •Lack of energy (9%)
    •Constipation (7%)
    •High blood sugar (6%)

  • Warnings of Jynarque vs. Samsca

    Common Side Effects for
    •Liver damage
    •High sodium levels, dehydration, and low blood volume
    •Interactions with other medications
    Common Side Effects for
    •Too rapid correction of blood sodium levels
    •Liver problems and liver failure
    •Dehydration and losing too much body fluid
    •Interactions with other medications
    •High blood potassium levels
    •Trouble with urination

  • Prices with our coupons for Jynarque vs. Samsca

    Learn more about Jynarque
    Learn more about Tolvaptan

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