Key takeaways
Hydroxyzine hydrochloride and escitalopram (Lexapro) are both used to treat anxiety, but they belong to different medication classes. Hydroxyzine HCl is an antihistamine that also helps with itching and can act as a sedative, while escitalopram is a selective serotonin reuptake inhibitor (SSRI) primarily used for depression and generalized anxiety disorder (GAD). Hydroxyzine HCl is available as a tablet, oral solution or syrup, and injection, and it is typically taken up to four times a day. In contrast, escitalopram is taken once daily, either as a tablet or oral solution. Both hydroxyzine HCl and escitalopram are available as lower-cost generics. Common side effects of hydroxyzine HCl include sleepiness and dry mouth, while escitalopram may cause nausea, trouble sleeping, and dizziness. Hydroxyzine hydrochloride can interact with medications that cause drowsiness, while escitalopram can interact with medications that increase serotonin levels, potentially leading to a serotonin syndrome, which is a rare but serious side effect.
