Key takeaways
Fluphenazine (generic, formerly known as Prolixin) and Perphenazine (generic, formerly known as Trilafon) are both typical antipsychotics used to treat psychotic disorders, but they have some differences. Fluphenazine is available in both short-acting and long-acting forms, which can be taken orally or via injection, while Perphenazine is only available in oral form. Fluphenazine is primarily used for psychotic disorders, whereas Perphenazine is also approved to treat severe nausea and vomiting. Both medications can cause movement problems, drowsiness, and weight gain. Perphenazine and fluphenazine oral forms need to be taken multiple times a day, while fluphenazine long-acting injection is given every 4 to 6 weeks. Both medications are not recommended for older adults with dementia-related psychosis due to an increased risk of death.
