Fluoxymesterone vs. Delatestryl for Breast Cancer and Testosterone Replacement: Important Differences and Potential Risks.

Key takeaways

Fluoxymesterone (Androxy) and testosterone enanthate are both medications used to treat low testosterone levels in males and metastatic breast cancer in females. However, they differ in several ways. Fluoxymesterone was available as an oral medication but has been discontinued in the United States. Testosterone enanthate, on the other hand, is given as an intramuscular injection, typically every 2 to 4 weeks. Common side effects of testosterone enanthate include acne and pain at the injection site. Additionally, testosterone enanthate has specific warnings about risks like blood clots, liver problems, and high calcium levels.

Androxy

(fluoxymesterone)

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testosterone enanthate

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Summary for Fluoxymesterone

Discontinued

Androxy (fluoxymesterone) is a medication used for treating conditions caused by low testosterone in males. It is also used to treat breast cancer in females. Androxy (fluoxymesterone) is no longer available in the United States because it was discontinued.

Pros and Cons for Fluoxymesterone

Pros

Cons

Summary for Delatestryl

Prescription only

Testosterone enanthate is a testosterone replacement therapy. It's mainly used in males to treat low testosterone levels and delayed puberty. It's also FDA-approved in females for treating metastatic breast cancer, but it's not a first-choice option for this condition. Testosterone enanthate is given as a deep injection into the muscle of the buttock, typically every 2 to 4 weeks by a healthcare professional (HCP). Side effects can include acne and pain or swelling at the injection site.

Indications for Delatestryl

Low testosterone (hypogonadism) in males
Delayed puberty in males
Metastatic breast cancer that have spread to the bones in females who've started menopause in the past 1 to 5 years

Pros and Cons for Delatestryl

Pros

Starts to work in 1-3 days to raise testosterone levels
Only needs to be used once every 2 to 4 weeks
Can be injected at home for some people
Available in a lower-cost, generic form

Cons

In females, can cause the development of male features, including deepening of the voice, acne, absence of menstrual periods, and more facial and body hair
Needs to be injected into the buttock muscle
Only available as an injection
Contains sesame oil, so might not be a good option if you have an allergy to sesame