What is Androxy?

Commonly Used Brand Name(s)Anadrol-50, Androderm, Androgel, Android, Androxy, Axiron, Danocrine, DHEA, First-Testosterone, First-Testosterone MC, Fortesta, Methitest, Teslac, Testopel Pellets, Testred, Vogelxo, Andriol, Androplex

OverviewTOP

Androgens are male hormones. Some androgens are naturally produced in the body and are necessary for the normal sexual development of males.

Androgens are used for several reasons, such as:

To replace the hormone when the body is unable to produce enough on its own.
To stimulate the beginning of puberty in certain boys who are late starting puberty naturally.
To treat certain types of breast cancer in females.

In addition, some of these medicines may be used for other conditions as determined by your doctor.

Androgens are available only with your doctor's prescription.

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Proper UseTOP

Take this medicine only as directed. Do not take more of it and do not take it more often than your doctor ordered . Doing so may increase the chance of side effects.

There are two types of testosterone skin patches. The matrix-type is applied to skin of the scrotum. The reservoir-type is never applied to the skin of the scrotum. It is applied to other parts of the body. Be sure you know which type you are using so that you will apply it properly. These skin patches come with patient directions. Read them carefully before using the patch.

For patients taking fluoxymesterone or methyltestosterone:

Take this medicine with food to lessen possible stomach upset, unless otherwise directed by your doctor.

For patients using the matrix-type skin patch of testosterone (Testoderm or Testoderm with Adhesives):

You must apply the patch to the scrotum because the medicine easily passes into your body at this area. Other areas of your skin are too thick for the medicine to work properly.
Wash and dry your hands thoroughly before and after handling the patch.
- Before applying the patch:
  - Clean and dry your scrotum.
  - You should also dry-shave this area once a week by using a shaver only (no soap or water). To dry-shave, stretch the skin of your scrotum with your fingers. Use short gentle strokes with no pressure on the razor to remove the hair. Do not use shaving cream or hair-removing creams (e.g., Nair).
  - You may sit with your legs apart or stand while applying the patch.
- To apply the patch:
  - Open the wrapper containing the patch at the point shown on the package.
  - Carefully remove the patch from its protective plastic liner by peeling the patch from the liner starting at the corner.
  - Warm your scrotum for a few seconds before applying the patch to achieve the best results. Stretch the skin of your scrotum gently to remove the folds by pulling the penis up and to the side. Another way is to pull your scrotum down. Use your first and middle fingers to stretch the skin of your scrotum.
  - Place the shiny side of the patch onto the warm stretched skin of your scrotum.
  - Press the shiny side of the patch firmly in place with the palm of your hand for about 10 seconds. Make sure there is good contact, especially around the edges. The patch should stick to your scrotum and show the natural wrinkles of your scrotum.
  - Put on comfortable, close-fitting briefs (underwear) after applying the patch.
  - If a patch becomes loose or falls off, you may reapply it or discard it and apply a new patch.
- To remove the skin patch:
  - Gently peel the patch from the skin.
  - You may reuse the patch after removing it for swimming, bathing, showering, or sexual activity. First, remove the patch and place the shiny (sticky) side up on a counter. Before you reapply the patch, be sure the skin on your scrotum is dry. Then, follow the directions to reapply the patch.
  - When the wearing period is over, fold the patch in half with the sticky sides together. Place the folded, used patch in its protective pouch or in aluminum foil. Be sure to throw it away out of the reach of children and pets.

For patients using the reservoir-type skin patch of testosterone (Androderm or Testoderm TTS):

Apply the patch called Androderm to the abdomen, back, thighs, or arms. Apply the patch called Testoderm TTS to the back, arms, or upper buttocks. Do not apply these patches to the scrotum.
Do not apply the patch to areas of the body that seem bony, such as the top of the shoulders or near the elbows, or to areas that may have to support your body while sleeping or sitting, such as the hips or shoulder blades. Apply each new patch to a different place. Do not reapply a patch to the same area of skin for 7 days.
Wash and dry your hands thoroughly before and after handling the patch.
- Before applying the patch, clean and dry the application site.
- To apply the patch:
  - Open the wrapper containing the patch at the point shown on the package.
  - Carefully remove the patch from its protective plastic liner by peeling the patch from the liner, starting at the corner.
  - Place the shiny side of the patch onto the skin.
  - Press the shiny side of the patch firmly in place with the palm of your hand for about 10 seconds. Be sure there is good contact, especially around the edges.
  - If a patch becomes loose or falls off, you may reapply it or discard it and apply a new patch.
- To remove the skin patch:
  - Gently peel the patch from the skin.
  - You do not need to remove this patch for swimming, bathing, showering, or sexual activity.
  - When the wearing period is over, fold the patch in half with the sticky sides together. Place the folded, used patch in its protective pouch or in aluminum foil. Be sure to throw it away out of the reach of children and pets.

DosingTOP

The dose medicines in this class will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of these medicines. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For fluoxymesterone

For oral dosage form (tablets):
- For androgen hormone replacement in men:
  - Adults—5 milligrams (mg) one to four times a day.
- For treatment of breast cancer in women:
  - Adults—10 to 40 mg a day in divided doses.
- For treatment of delayed sexual development in boys:
  - Children—2.5 to 10 mg a day for four to six months.

For methyltestosterone

For oral dosage forms (capsules or tablets):
- For androgen hormone replacement in men:
  - Adults—10 to 50 milligrams (mg) a day.
- For treatment of breast cancer in women:
  - Adults—50 mg one to four times a day. Your doctor may decrease your dose to 50 mg two times a day after two to four weeks.
- For treatment of delayed sexual development in boys:
  - Children—5 to 25 mg a day for four to six months.

For testosterone

For injection dosage form:
- For androgen hormone replacement in men:
  - Adults—25 to 50 milligrams (mg) injected into a muscle two or three times a week.
- For treatment of breast cancer in women:
  - Adults—50 to 100 mg injected into a muscle three times a week.
- For treatment of delayed sexual development in boys:
  - Children—Up to 100 mg injected into a muscle once a month for four to six months.
For subcutaneous dosage form (implants):
- For androgen hormone replacement in men:
  - Adults—150 to 450 milligram (mg) (two to six implants) inserted into the skin every three to six months.
- For treatment of delayed sexual development in boys:
  - Children—Use and dose must be determined by your doctor.
For topical dosage forms:
- For androgen hormone replacement in men:
  - Adults—The recommended starting dose is 5 grams applied once daily (preferably in the morning) to clean, dry , intact skin of the shoulders and upper arms and/or abdomen. Allow the application sites to dry prior to dressing and wash hands with soap and water after application.
  - Children—Use and dose must be determined by your doctor.
  - Adults—4 or 6 mg (one patch) applied to your scrotum once a day at about 8 a.m. The patch should be worn at least twenty-two of the twenty-four hours in a day.
  - Children—Use and dose must be determined by your doctor.
  - Adults and teenagers 15 years of age and older—2.5 to 7.5 mg (one to three patches) applied to the abdomen, back, thighs, or upper arms once a day at about 10 p.m. The patch(es) should be worn for twenty-four hours a day.
  - Children up to 15 years of age—Use and dose must be determined by your doctor.
  - Adults—5 mg (one patch) applied to the back, arms, or upper buttocks once a day at about 8 a.m. Your doctor may increase your dose if necessary. The patch should be worn at least twenty-two of the twenty-four hours in a day.
  - Children up to 18 years of age—Use and dose must be determined by your doctor.

For testosterone cypionate or testosterone enanthate

For injection dosage form:
- For androgen hormone replacement in men:
  - Adults—50 to 400 milligrams (mg) injected into a muscle every two to four weeks.
- For treatment of breast cancer in women:
  - Adults—200 to 400 mg injected into a muscle every two to four weeks.
- For treatment of delayed sexual development in boys:
  - Children—Up to 100 mg injected into a muscle once a month for four to six months.

For testosterone propionate

For injection dosage form:
- For androgen hormone replacement in men:
  - Adults—25 to 50 milligrams (mg) injected into a muscle two or three times a week.
- For treatment of breast cancer in women:
  - Adults—50 to 100 mg injected into a muscle three times a week.
- For treatment of delayed sexual development in boys:
  - Children—Up to 100 milligrams injected into a muscle once a month for four to six months.

For testosterone undecanoate

For oral dosage form (capsules):
- For androgen hormone replacement in men:
  - Adults—120 to 160 milligrams (mg) divided into two doses a day taken with meals for two to three weeks. Then dose is reduced to 40 to 120 mg a day, taken with meals, and divided into 2 doses a day when possible.

Missed DoseTOP

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

If you forget to wear or change a patch, put one on as soon as you can. If it is almost time to put on your next patch, wait until then to apply a new patch and skip the one you missed. Do not apply extra patches to make up for a missed dose.

For topical dosage forms (patches): If you miss a dose of this medicine or your patch falls off within 12 hours after applying it and cannot be reapplied, skip the rest of the dose and go back to your regular dosing schedule. Do not double doses.

If you have any questions about this, check with your doctor.

Use & StorageTOP

Keep out of the reach of children.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Do not keep outdated medicine or medicine no longer needed.

AllergiesTOP

Tell your doctor if you have ever had any unusual or allergic reaction to medicines in this group or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

PediatricTOP

Androgens may cause children to stop growing. In addition, androgens may make male children develop too fast sexually and may cause male-like changes in female children

GeriatricTOP

When older male patients are treated with androgens, they may have an increased risk of enlarged prostate (a male gland) or their existing prostate cancer may get worse. For these reasons, a prostate examination and a blood test to check for prostate cancer is often done before androgens are prescribed for men over 50 years of age. These examinations may be repeated during treatment.

PregnancyTOP

Androgens are not recommended during pregnancy. When given to pregnant women, the medicine has caused male features to develop in female babies.

Breast FeedingTOP

Use is not recommended in nursing mothers, since androgens may pass into the breast milk and may cause unwanted effects in the nursing baby, such as premature (too early) sexual development in males and development of male features in female babies.

Drug InteractionsTOP

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking any of these medicines, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using medicines in this class with any of the following medicines is not recommended. Your doctor may decide not to treat you with a medication in this class or change some of the other medicines you take.

Simvastatin

Using medicines in this class with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Acenocoumarol
Anisindione
Atorvastatin
Bupropion
Dasabuvir
Dicumarol
Fluvastatin
Lovastatin
Paclitaxel
Paclitaxel Protein-Bound
Phenindione
Phenprocoumon
Warfarin

Other InteractionsTOP

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

PrecautionsTOP

Your doctor should check your progress at regular visits to make sure this medicine does not cause unwanted effects.

For patients with diabetes mellitus (sugar diabetes):

This medicine may affect blood sugar levels. If you notice a change in the results of your blood or urine sugar tests or if you have any questions, check with your doctor.

For patients using the brand name Androgel:

Wait 5 or 6 hours after applying the gel before showering or swimming.
Gel contains alcohol which is flammable- avoid fire, flame or smoking until the gel is dried.