Evrysdi vs. Spinraza for Musculoskeletal Conditions: Important Differences and Potential Risks.

Evrysdi

(risdiplam)

Spinraza

(nusinersen)

Summary for Evrysdi

Prescription only

Evrysdi (risdiplam) is used to treat a genetic condition called spinal muscular atrophy (SMA) in adults and children. It's a type of medication called an RNA splicing modifier. It works to help improve the motor function of people with SMA. Evrysdi (risdiplam) comes as a tablet and oral solution, and you take the medication by mouth once per day. But your specific dose depends on your age and weight. Side effects can include fever, diarrhea, and rash.

Indications for Evrysdi

Spinal muscular atrophy (SMA) in adults and children

Pros and Cons for Evrysdi

Pros

Taken by mouth once a day
Okay for people of all ages with SMA to take
Available as a tablet and a liquid

Cons

Can cause diarrhea
Must follow a lot of instructions to take the liquid safely (e.g., refrigeration, no mixing with food)
Can take months to notice better muscle strength

Common Side Effects for Evrysdi

Fever (22%)
Diarrhea (17%)
Rash (17%)

Warnings for Evrysdi

Possible interactions with other medications
Possible harm to an unborn baby
Possible fertility problems in males

Summary for Spinraza

Prescription only

Spinraza (nusinersen) is an injectable medication used to treat spinal muscular atrophy (SMA) in children and adults. This medication is injected into the spinal canal by a trained healthcare provider at a treatment facility.

Indications for Spinraza

Treatment of spinal muscular atrophy (SMA) in children and adults

Pros and Cons for Spinraza

Pros

Can be given to both children and adults of all ages
Maintenance dose only has to be given every 4 months
Medication gets injected directly into the spinal area, where movement is controlled

Cons

Must be given by injection, so it might be uncomfortable
Only given by a trained healthcare provider
Must complete blood work and urine test before each dose

Common Side Effects for Spinraza

Infantile-onset SMA (affects infants)

Lower respiratory infection (55%)
Constipation (35%)
Teething (18%)
Urinary tract infection (9%)
Stuffy nose (8%)
Ear infection (6%)
Passing gas (5%)
Weight loss (5%)

Later-onset SMA (affects children and adults)

Fever (43%)
Headache (29%)
Vomiting (29%)
Back pain (25%)
Nosebleed (7%)
Falls (5%)
Stuffy nose (5%)
Seasonal allergy (5%)

Warnings for Spinraza

Bleeding risk
Kidney damage

Prices with our coupons for Evrysdi vs. Spinraza

Evrysdi2 ml / 80ml of 0.75mg/ml

$30,199.29-

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Spinraza1 vial / 5ml of 2.4mg/ml

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Evrysdi vs. Spinraza

Evrysdi

Spinraza

Summary for Evrysdi

Indications for Evrysdi

Pros and Cons for Evrysdi

Pros

Cons

Common Side Effects for Evrysdi

Warnings for Evrysdi

Summary for Spinraza

Indications for Spinraza

Pros and Cons for Spinraza

Pros

Cons

Common Side Effects for Spinraza

Warnings for Spinraza

Prices with our coupons for Evrysdi vs. Spinraza

Browse medications by letter

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Evrysdi

Spinraza

Summary for Evrysdi

Indications for Evrysdi

Pros and Cons for Evrysdi

Pros

Cons

Common Side Effects for Evrysdi

Warnings for Evrysdi

Summary for Spinraza

Indications for Spinraza

Pros and Cons for Spinraza

Pros

Cons

Common Side Effects for Spinraza

Warnings for Spinraza