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Compare Evrysdi vs. Spinraza

Head-to-head comparisons of medication uses, side effects, warnings, and more.

  • Evrysdi (risdiplam)
    Spinraza (nusinersen)
  • Evrysdi (risdiplam)
    Spinraza (nusinersen)

  • Summary of Evrysdi vs. Spinraza

    Summary for SMN2 splicing modifier
    Prescription only

    Evrysdi (risdiplam) is used to treat a genetic condition called spinal muscular atrophy (SMA) in adults and children. It's a type of medication called an RNA splicing modifier. It works to help improve the motor function of people with SMA. Evrysdi (risdiplam) comes as a tablet and oral solution, and you take the medication by mouth once per day. But your specific dose depends on your age and weight. Side effects can include fever, diarrhea, and rash.

    Summary for Antisense oligonucleotide
    Prescription only

    Spinraza (nusinersen) is an injectable medication used to treat spinal muscular atrophy (SMA) in children and adults. This medication is injected into the spinal canal by a trained healthcare provider at a treatment facility.

  • Indications of Evrysdi vs. Spinraza

    Indications for
    •Spinal muscular atrophy (SMA) in adults and children
    Indications for
    •Treatment of spinal muscular atrophy (SMA) in children and adults

  • Pros and Cons of Evrysdi vs. Spinraza

    Pros and Const for SMN2 splicing modifier
    Pros
    •Taken by mouth once a day
    •Okay for people of all ages with SMA to take
    •Available as a tablet and a liquid
    Cons
    •Can cause diarrhea
    •Must follow a lot of instructions to take the liquid safely (e.g., refrigeration, no mixing with food)
    •Can take months to notice better muscle strength
    Pros and Const for Antisense oligonucleotide
    Pros
    •Can be given to both children and adults of all ages
    •Maintenance dose only has to be given every 4 months
    •Medication gets injected directly into the spinal area, where movement is controlled
    Cons
    •Must be given by injection, so it might be uncomfortable
    •Only given by a trained healthcare provider
    •Must complete blood work and urine test before each dose

  • Common Side Effects of Evrysdi vs. Spinraza

    Common Side Effects for
    •Fever (22%)
    •Diarrhea (17%)
    •Rash (17%)
    Common Side Effects for

    Infantile-onset SMA (affects infants)

    •Lower respiratory infection (55%)
    •Constipation (35%)
    •Teething (18%)
    •Urinary tract infection (9%)
    •Stuffy nose (8%)
    •Ear infection (6%)
    •Passing gas (5%)
    •Weight loss (5%)

    Later-onset SMA (affects children and adults)

    •Fever (43%)
    •Headache (29%)
    •Vomiting (29%)
    •Back pain (25%)
    •Nosebleed (7%)
    •Falls (5%)
    •Stuffy nose (5%)
    •Seasonal allergy (5%)

  • Warnings of Evrysdi vs. Spinraza

    Common Side Effects for
    •Possible interactions with other medications
    •Possible harm to an unborn baby
    •Possible fertility problems in males
    Common Side Effects for
    •Bleeding risk
    •Kidney damage

  • Prices with our coupons for Evrysdi vs. Spinraza

    Learn more about Evrysdi
    Learn more about Spinraza

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