Key takeaways
Estradiol patch (Climara) and estradiol spray (Evamist) are both estrogen replacement therapies used to relieve menopause symptoms like hot flashes and night sweats. They are similar in that they both replace estrogen lost during menopause. However, they differ in their application methods and specific uses. Climara is a transdermal patch applied once a week to the lower stomach or upper buttocks, while Evamist is a topical spray applied daily to the inner forearm. Climara is also used to prevent osteoporosis after menopause, whereas Evamist is specifically for moderate-to-severe vasomotor symptoms. Climara is available as a lower-cost generic, but Evamist does not have a generic version. Both medications can cause breast tendersness and headaches and increase the risk of certain cancers, blood clots, and strokes. If you have a uterus, you may need to take progestin with either medication.
