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Estrace vs. Premarin

Head-to-head comparisons of medication uses, side effects, warnings, and more.

estradiol tablet

 

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Premarin tablet

 

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Summary for Estrace

Prescription only

Estradiol tablet is an estrogen hormone used to treat menopause symptoms like hot flashes, night sweats, and vaginal irritation. It also helps prevent bone loss (osteoporosis) after menopause. Though not as common, it's also FDA approved to treat certain advanced stages of breast and prostate cancer. The dose depends on your condition, but tablets are typically taken by mouth 1 to 3 times a day. Common side effects include nausea, vomiting, headache, and breast pain.

Indications for Estrace

Pros and Cons for Estrace

Pros

  • Relieves multiple menopausal symptoms
  • Available in many strengths, allowing you to customize your dose
  • Comes as a tablet that you take by mouth

Cons

  • Raises your risk of certain cancers, blood clots, and strokes
  • Some people might need to take it with another hormone called progestin
  • Not a first-choice medication for treating bone loss after menopause

Common Side Effects for Estrace

  • Headache
  • Breast pain
  • Abnormal vaginal bleeding or spotting
  • Stomach cramps or bloating
  • Nausea
  • Vomiting
  • Hair loss

Warnings for Estrace

  • Uterine (endometrial) cancer
  • Breast cancer
  • Blood clots and strokes
  • Heart disease and heart attacks
  • Dementia
  • Gallbladder and liver problems
  • Vision problems
  • High triglycerides
  • Low thyroid hormone levels (hypothyroidism)
  • Fluid Retention
  • Changes in calcium levels in the blood
  • Worsening of other health conditions

Summary for Premarin

Prescription only

Premarin (conjugated estrogens) oral tablet is an estrogen hormone replacement therapy (HRT) used to treat menopause symptoms, such as hot flashes and vaginal dryness, and other conditions caused by low estrogen levels. It can also help prevent osteoporosis after menopause and treat certain advanced breast or prostate cancers. Depending on why you're taking it, you might take it by mouth every day or in cycles. Common side effects include headache, stomach pain, nausea, and breast pain.

Indications for Premarin

Pros and Cons for Premarin

Pros

  • Relieves multiple menopause symptoms
  • Available in multiple strengths
  • Comes as a tablet that you take by mouth

Cons

  • Raises your risk of blood clots, stroke, and certain cancers
  • Some people might need to take it with another hormone called progestin
  • Can cause vaginal bleeding and spotting

Common Side Effects for Premarin

  • Headache (13-14%)
  • Abnormal vaginal bleeding (2-13%)
  • Breast pain (7-12%)
  • Stomach pain (8-11%)
  • Passing gas (4-6%)
  • Vaginal discharge (4-5%)
  • Back pain (3-5%)
  • General pain (3-5%)
  • Nausea (3-5%)
  • Insomnia (3-5%)
  • Depression (3-5%)
  • Weakness (2-5%)

Warnings for Premarin

  • Blood clots, heart attacks, and strokes
  • Uterine (endometrial) cancer
  • Breast cancer
  • Dementia
  • Ovarian cancer
  • Liver or gallbladder problems
  • Changes in calcium levels in the blood
  • Vision problems
  • High triglycerides (fat) levels
  • Low thyroid hormone levels
  • Buildup of fluids in your body (fluid retention)
  • Worsening of certain other health conditions

Prices with our coupons for Estrace vs. Premarin

Price Card Drug Icon
Estradiol90 tablets / 1mg
$19.72$71.63
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Price Card Drug Icon
Premarin Vaginal Cream1 tube / 30g of 0.625mg/g
$236.65$570.98
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