Compare Estrace vs. Premarin
Head-to-head comparisons of medication uses, side effects, warnings, and more.
- Estradiol (Estrace) vaginal creamPremarin
- Estradiol (Estrace) vaginal creamPremarin
Summary of Estrace vs. Premarin
Summary for Estrogen replacementPrescription onlyEstradiol (Estrace) vaginal cream is used to lessen certain symptoms related to menopause, such as vaginal itching and dryness. It's a hormone replacement therapy that's made of estradiol, a form of estrogen. Estradiol (Estrace) vaginal cream is applied vaginally with an applicator. Typically, your gynecologist or healthcare professional (HCP) will prescribe it daily for a few weeks, and then lower the dose to a few times a week after that. Some side effects of estradiol (Estrace) vaginal cream include vaginal burning and irritation.
Summary for Estrogen replacementPrescription onlyPremarin (conjugated estrogens) is an oral estrogen hormone tablet that's used to treat various conditions in adults. Most commonly, it relieves menopausal symptoms such as vaginal dryness and hot flashes. The medication is also used for treating low estrogen levels, certain advanced stages of breast or prostate cancers, and osteoporosis after menopause. Depending on what you're using it for, the medication can be taken daily or in cycles. Side effects include headache, stomach pain, nausea, and breast pain.
Indications of Estrace vs. Premarin
Indications for•Treatment of vaginal itching, dryness, and burning due to menopauseIndications for•Hot flashes, night sweats, and flushes caused by menopause•Vaginal dryness caused by menopause•Low estrogen levels due to certain conditions•Certain advanced stages of breast cancer•Certain advanced stages of prostate cancer•Prevention of bone loss (osteoporosis) after menopausePros and Cons of Estrace vs. Premarin
Pros and Const for Estrogen replacementPros•Only need to use it 1 to 3 times per week after your symptoms improve•Applied directly to the vagina where symptoms are occurring•Available as a lower-cost genericCons•Might be challenging and uncomfortable to use•Raises your risk for certain cancers, blood clots, and strokes•Some people might need to take it with another hormone called progestinPros and Const for Estrogen replacementPros•Relieves multiple menopausal symptoms•Available in multiple strengths, allowing you to customize your dose•Comes as a tablet that you take by mouthCons•Raises your risk of certain cancers, blood clots, and strokes•Some people might need to take it with another hormone called progestin•Not a first-choice medication for treating bone loss after menopauseCommon Side Effects of Estrace vs. Premarin
Common Side Effects for•Application site burning and irritation•Headache•Irregular vaginal bleeding or spotting•Nausea or vomiting•Bloating•Hair loss•Vaginal yeast infectionCommon Side Effects for•Headache (13-14%)•Abnormal vaginal bleeding (2-13%)•Breast pain (7-12%)•Stomach pain (8-11%)•Passing gas (4-6%)•Vaginal discharge (4-5%)•Back pain (3-5%)•General pain (3-5%)•Nausea (3-5%)•Insomnia (3-5%)•Depression (3-5%)•Weakness (2-5%)Warnings of Estrace vs. Premarin
Common Side Effects for•Uterine (endometrial) cancer•Breast cancer•Blood clots and strokes•Heart disease and heart attacks•Dementia•Gallbladder and liver problems•Changes in calcium levels in the blood•Vision problems•High triglycerides•Low thyroid hormone levels (hypothyroidism)•Fluid retention (edema)•Worsening of other health conditionsCommon Side Effects for•Uterine (endometrial) cancer•Breast cancer•Blood clots and stroke•Heart disease and heart attacks•Dementia•Gallbladder and liver problems•Vision problems•High triglycerides•Low thyroid hormone levels (hypothyroidism)•Fluid Retention•Changes in calcium levels in the blood•Worsening of other health conditionsPrices with our coupons for Estrace vs. Premarin
Browse medications
View AllResearch prescriptions and over-the-counter medications from A to Z, compare drug prices, and start saving.