Estrace vs. Premarin Vaginal Cream for Atrophic Vaginitis: Important Differences and Potential Risks.

Estradiol

(Estrace)

Premarin vaginal cream

Summary for Estrace

Prescription only

Estradiol (Estrace) vaginal cream is used to lessen certain symptoms related to menopause, such as vaginal itching and dryness. It's a hormone replacement therapy that's made of estradiol, a form of estrogen. Estradiol (Estrace) vaginal cream is applied vaginally with an applicator. Typically, your gynecologist or healthcare professional (HCP) will prescribe it daily for a few weeks, and then lower the dose to a few times a week after that. Some side effects of estradiol (Estrace) vaginal cream include vaginal burning and irritation.

Indications for Estrace

Treatment of vaginal itching, dryness, and burning due to menopause

Pros and Cons for Estrace

Pros

Only need to use it 1 to 3 times per week after your symptoms improve
Applied directly to the vagina where symptoms are occurring
Available as a lower-cost generic

Cons

Might be challenging and uncomfortable to use
Raises your risk for certain cancers, blood clots, and strokes
Some people might need to take it with another hormone called progestin

Common Side Effects for Estrace

Application site burning and irritation
Breast pain or tenderness
Headache
Irregular vaginal bleeding or spotting
Nausea or vomiting
Bloating
Hair loss
Vaginal yeast infection

Warnings for Estrace

Uterine (endometrial) cancer
Breast cancer
Blood clots and strokes
Heart disease and heart attacks
Dementia
Gallbladder and liver problems
Changes in calcium levels in the blood
Vision problems
High triglycerides
Low thyroid hormone levels (hypothyroidism)
Fluid retention (edema)
Worsening of other health conditions

Summary for Premarin Vaginal Cream

Prescription only

Premarin (conjugated estrogens) vaginal cream is an estrogen hormone cream used to treat adults with vaginal symptoms due to menopause, such as vaginal dryness and pain during sex. Depending on what you're taking the vaginal cream for, the dosage can be different. You might apply it in cycles (daily for 3 weeks, then no cream for 1 week) or simply just twice a week. Common side effects include headache, pelvic pain, and breast pain.

Indications for Premarin Vaginal Cream

Vaginal dryness and irritation
Pain during sex caused by menopause

Pros and Cons for Premarin Vaginal Cream

Pros

Is applied directly into the vagina to relieve symptoms locally
Good option if for those who have trouble swallow pills
Smaller amounts are absorbed into the body compared to tablets or injections

Cons

Applying the cream can be messy
Need to remember stop taking it for a week if your dosage is in cycles
Can take several weeks to improve symptoms

Common Side Effects for Premarin Vaginal Cream

Breast pain (2-5%)
Headache (2-4%)
Pelvic pain (3%)
Vaginal discharge (2-3%)

Warnings for Premarin Vaginal Cream

Uterine (endometrial) cancer
Breast cancer
Blood clots and stroke
Heart disease and heart attacks
Dementia
Gallbladder and liver problems
Vision problems
High triglycerides
Low thyroid hormone levels (hypothyroidism)
Fluid Retention
Changes in calcium levels in the blood
Worsening of other health conditions

Prices with our coupons for Estrace vs. Premarin Vaginal Cream

Estradiol90 tablets / 1mg

$20.22$71.34

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Premarin Vaginal Cream1 tube / 30g of 0.625mg/g

$236.65$570.99

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Estrace vs. Premarin Vaginal Cream

Estradiol

Premarin vaginal cream

Summary for Estrace

Indications for Estrace

Pros and Cons for Estrace

Pros

Cons

Common Side Effects for Estrace

Warnings for Estrace

Summary for Premarin Vaginal Cream

Indications for Premarin Vaginal Cream

Pros and Cons for Premarin Vaginal Cream

Pros

Cons

Common Side Effects for Premarin Vaginal Cream

Warnings for Premarin Vaginal Cream

Prices with our coupons for Estrace vs. Premarin Vaginal Cream

Browse medications by letter

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Estradiol

Premarin vaginal cream

Summary for Estrace

Indications for Estrace

Pros and Cons for Estrace

Pros

Cons

Common Side Effects for Estrace

Warnings for Estrace

Summary for Premarin Vaginal Cream

Indications for Premarin Vaginal Cream

Pros and Cons for Premarin Vaginal Cream

Pros

Cons

Common Side Effects for Premarin Vaginal Cream

Warnings for Premarin Vaginal Cream