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Escitalopram vs. Sertraline

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Escitalopram

(Lexapro)

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Sertraline

(Zoloft)

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Summary for Escitalopram

Prescription only

Escitalopram, also known by its brand name, Lexapro, is a selective serotonin reuptake inhibitor (SSRI). It's a first-choice antidepressant to treat depression and anxiety in adults and children. The medication is available as a tablet and oral solution, in both brand and generic forms. A dose is typically taken by mouth once per day. Some common side effects include nausea, trouble sleeping (insomnia), and dizziness.

Indications for Escitalopram

Pros and Cons for Escitalopram

Pros

  • First-choice medication for anxiety and depression
  • Only need to take it once a day
  • Generally has fewer side effects compared to other antidepressants
  • Can be taken with or without food

Cons

  • Can take up to 2 months before you feel the the full benefits
  • Risk of certain sexual problems
  • Can raise your risk for bleeds
  • Can cause withdrawal symptoms if you suddenly stop taking it

Common Side Effects for Escitalopram

  • Headache (24%)
  • Nausea (15-18%)
  • Ejaculation problems (9-14%)
  • Sleepiness (6-13%)
  • Trouble sleeping (9-12%)
  • Dry mouth (6-9%)
  • Diarrhea (8%)
  • Tiredness (5-8%)

Warnings for Escitalopram

  • Worsening depression, suicidal thoughts, and unusual behavior
  • Serotonin syndrome
  • Stopping escitalopram (Lexapro) too suddenly
  • Risk of bleeding
  • Not for use alone in bipolar disorder
  • Glaucoma
  • Life-threatening abnormal heart rhythm (QT prolongation)
  • Low blood sodium levels
  • Sexual problems

Summary for Sertraline

Prescription only

Sertraline (Zoloft) is a selective serotonin reuptake inhibitor (SSRI). It's used to treat different mental health conditions, including depression and certain types of anxiety disorder, such as panic disorder. It's typically taken by mouth once per day. This medication is available as both a tablet and liquid. Common side effects of sertraline (Zoloft) include nausea, diarrhea, and dry mouth. It's best to avoid alcohol while taking sertraline (Zoloft) because this combination can worsen side effects of sertraline (Zoloft).

Indications for Sertraline

Pros and Cons for Sertraline

Pros

Cons

  • Can take up to 2 months before you feel the full benefits
  • More likely to cause diarrhea compared to other SSRIs
  • Might make it more difficult for you to fall asleep
  • Can cause withdrawal symptoms if you suddenly stop taking it
  • The liquid form contains alcohol

Common Side Effects for Sertraline

  • Nausea (26%)
  • Diarrhea (20%)
  • Difficulty sleeping (20%)
  • Dry mouth (14%)
  • Sleepiness (12%)

Warnings for Sertraline

  • Worsening depression, suicidal thoughts, and unusual behavior
  • Serotonin syndrome
  • Risk of bleeding
  • Not for use alone in bipolar disorder
  • Glaucoma
  • Life-threatening abnormal heart rhythm (QT prolongation)
  • Low blood sodium levels

Prices with our coupons for Escitalopram vs. Sertraline

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Escitalopram30 tablets / 10mg
$9.51$17.23
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Sertraline30 tablets / 50mg
$9.26$33.63
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