Doptelet vs. Promacta for Thrombocytopenia: Important Differences and Potential Risks.

Doptelet

(avatrombopag)

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Promacta

(eltrombopag)

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Summary for Doptelet

Prescription only

Doptelet (avatrombopag) is a prescription medication that helps the body make more platelets, which can lower the risk of bleeding. It’s used to treat low platelet levels in adults with chronic liver disease who are having a medical procedure and in adults and children with chronic immune thrombocytopenia (ITP). It comes as Doptelet tablets and Doptelet Sprinkle oral granules, both taken by mouth with a starting dose of once a day. Common side effects include headache, tiredness, and fever.

Indications for Doptelet

Low platelet counts in people with chronic liver disease (CLD) who are scheduled for a medical procedure - adults only
Low platelet counts in people with chronic immune thrombocytopenia (ITP) when other treatments haven’t worked - adults and children 1 year and older

Pros and Cons for Doptelet

Pros

Helps raise platelet levels without a platelet transfusion
Taken by mouth as a tablet or sprinkle capsule
Approved for both adults and children

Cons

Must be taken with food
Requires regular platelet blood tests for ITP
Not safe in pregnancy or breastfeeding

Common Side Effects for Doptelet

Adults with CLD before a procedure:

Fever (10%)
Stomach pain (7%)
Nausea (7%)
Headache (6%)
Tiredness (4%)
Swelling in the arms or legs(3%)

Adults with ITP:

Headache (31%)
Tiredness (28%)
Bruising (26%)
Nosebleed (19%)
Upper respiratory tract infection (15%)
Joint pain (13%)
Bleeding Gums (13%)
Small red or purple spots on the skin (11%)
Common cold symptoms (10%)

Children with ITP:

Viral infection (20%)
Common cold symptoms (20%)
Cough (17%)
Mouth and throat pain (13%)

Warnings for Doptelet

Blood Clots

Summary for Promacta

Prescription only

Promacta (eltrombopag) is an oral medication used to treat specific blood-related conditions like immune thrombocytopenic purpura (ITP). It’s also used with other medications to raise platelet levels in people with long-term hepatitis C. Common side effects include nausea, fever, tiredness, and headache. Currently Promacta (eltrombopag) is a brand-name medication only, so generics aren't available on the market.

Indications for Promacta

Low platelet count in people with immune thrombocytopenic purpura (ITP) when other medications haven’t worked - adults and children
Low platelet count in people with long-term hepatitis C - adults only
Used alone or with other medications in people who can’t make enough blood cells (severe aplastic anemia) - adults and children

Pros and Cons for Promacta

Pros

Oral tablet taken once daily by mouth
Also available as an oral suspension, which is a good option for people who have trouble swallowing
Can be used in young children
No injection is required

Cons

Risk of blood clots and liver damage
Is a specialty drug that might not be available at all local pharmacies
Might need to undergo many dose changes until the right dose is found
Oral suspension preparation and administration can be difficult for some people

Common Side Effects for Promacta

Long-term ITP and severe/refractory aplastic anemia:

Nausea (4-33%)
Fever (9-14%)
Tiredness (5-28%)
Cough (9-23%)
Headache (10-21%)
Diarrhea (9-21%)

The risk of developing these side effects depends on your dose.

Long-term hepatitis C:

Low red blood cell levels (anemia) (40%)
Fever (30%)
Tiredness (28%)
Headache (21%)
Nausea (19%)
Diarrhea (19%)

People with hepatitis C who reported side effects were also taking interferon and ribavirin together with Promacta (eltrombopag). All of the listed side effects for people with long-term hepatitis C might not be caused by Promacta (eltrombopag) alone.

Warnings for Promacta

Liver damage
Blood clots
Higher risk of serious blood cancer and death in people with myelodysplastic syndromes (MDS)
Cataracts

Prices with our coupons for Doptelet vs. Promacta

Doptelet1 package / 30 tablets of 20mg

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Eltrombopag30 tablets / 50mg of

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Doptelet vs. Promacta

Doptelet

Promacta

Summary for Doptelet

Indications for Doptelet

Pros and Cons for Doptelet

Pros

Cons

Common Side Effects for Doptelet

Warnings for Doptelet

Summary for Promacta

Indications for Promacta

Pros and Cons for Promacta

Pros

Cons

Common Side Effects for Promacta

Warnings for Promacta

Prices with our coupons for Doptelet vs. Promacta

Browse medications by letter

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Doptelet

Promacta

Summary for Doptelet

Indications for Doptelet

Pros and Cons for Doptelet

Pros

Cons

Common Side Effects for Doptelet

Warnings for Doptelet

Summary for Promacta

Indications for Promacta

Pros and Cons for Promacta

Pros

Cons

Common Side Effects for Promacta

Warnings for Promacta