Darzalex vs. Sarclisa for Multiple Myeloma: Important Differences and Potential Risks.

Darzalex

(daratumumab)

Sarclisa

(isatuximab)

Summary for Darzalex

Prescription only

Darzalex (daratumumab) is an anti-CD38 monoclonal antibody. It's used to treat multiple myeloma in adults, often in combination with other anticancer medications. Darzalex (daratumumab) is given as an intravenous infusion through your vein (IV). Typically, you receive it every week or every few weeks, depending on where you are in the treatment process. Some common side effects of Darzalex (daratumumab) include infusion-related reactions, higher risk of infection, and feeling tired.

Indications for Darzalex

Adults newly diagnosed with multiple myeloma (MM), but not able to receive stem cell transplant (in combination with other anticancer medications)
Adults newly diagnosed with MM and able to receive stem cell transplant (in combination with other anticancer medications)
Adults with advanced MM who already received but didn’t respond well to at least one prior anticancer treatment (in combination with other anticancer medications)
Adults with advanced MM who already received but didn’t respond well to at least three prior anticancer treatments (given alone)

Pros and Cons for Darzalex

Pros

Recommended treatment option for people with multiple myeloma
Works in a more specific, targeted way than traditional chemotherapy
Not known to cause hair loss

Cons

Might cause serious infusion-related reactions
Each infusion lasts several hours long, so not very convenient
Infused into the veins

Common Side Effects for Darzalex

Infusion-related reactions
Decreases in blood cell counts
Cold-like symptoms (upper respiratory infection)
Diarrhea
Constipation
Nerve damage causing tingling, numbness or pain
Tiredness
Swollen hands, ankles, or feet
Nausea
Cough
Fever
Shortness of breath
Feeling weak

Warnings for Darzalex

Infusion-related reactions
Changes in lab test results for blood transfusions
Lower white blood cell counts (risk of infection)
Lower platelet counts (risk of bleeding)
Changes in test results for treatment response
Harm to unborn baby

Summary for Sarclisa

Prescription only

Sarclisa (isatuximab or isatuximab-irfc) is a monoclonal antibody that’s used to treat a type of blood cancer called multiple myeloma. It helps stop the cancer from growing and spreading. Sarclisa (isatuximab) is given as an intravenous infusion through your vein (IV). It’s typically given together with two other medications to treat cancer. Sarclisa (isatuximab) might cause side effects such as infusion-related reactions, low white blood cell counts, and diarrhea.

Indications for Sarclisa

Multiple myeloma in adults who’ve received at least two previous therapies, given together with Pomalyst (pomalidomide) and dexamethasone
Multiple myeloma in adults who’ve received one to three previous therapies, given together with Kyprolis (carfilzomib) and dexamethasone

Pros and Cons for Sarclisa

Pros

Recommended treatment option for previously-treated multiple myeloma
Works in a more specific, targeted way than traditional chemotherapy
Doesn’t commonly cause typical chemotherapy side effects, such as nausea, vomiting, or hair loss

Cons

Given as an infusion through the veins, so requires a needle for administration
Might cause serious infusion-related reactions
Might make it more difficult for your body to fight infection

Common Side Effects for Sarclisa

Lower red blood cell counts (up to 99%)
Lower white blood cell counts (up to 96%)
Lower platelet counts (up to 94%)
Upper respiratory infection (e.g., sinus infections, bronchitis; up to 67%)
Infusion-related reaction (up to 46%)
Tiredness (42%)
Higher blood pressure (37%)
Pneumonia (up to 36%)
Diarrhea (up to 36%)
Trouble breathing (up to 29%)
Cough (23%)

Warnings for Sarclisa

Infusion-related reactions
Low white blood cell counts
New cancers
Changes to other lab test results
Harm to unborn baby

Prices with our coupons for Darzalex vs. Sarclisa

Darzalex2 vials / 20ml of 20mg/ml

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Sarclisa2 vials / of 500mg/25ml

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Darzalex vs. Sarclisa

Darzalex

Sarclisa

Summary for Darzalex

Indications for Darzalex

Pros and Cons for Darzalex

Pros

Cons

Common Side Effects for Darzalex

Warnings for Darzalex

Summary for Sarclisa

Indications for Sarclisa

Pros and Cons for Sarclisa

Pros

Cons

Common Side Effects for Sarclisa

Warnings for Sarclisa

Prices with our coupons for Darzalex vs. Sarclisa

Compare other Multiple Myeloma drugs

Browse medications by letter

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Darzalex

Sarclisa

Summary for Darzalex

Indications for Darzalex

Pros and Cons for Darzalex

Pros

Cons

Common Side Effects for Darzalex

Warnings for Darzalex

Summary for Sarclisa

Indications for Sarclisa

Pros and Cons for Sarclisa

Pros

Cons

Common Side Effects for Sarclisa

Warnings for Sarclisa