Compare Darzalex vs. Sarclisa
Head-to-head comparisons of medication uses, side effects, warnings, and more.
- Darzalex (daratumumab)Sarclisa (isatuximab)
- Darzalex (daratumumab)Sarclisa (isatuximab)
Summary of Darzalex vs. Sarclisa
Summary for Anti-CD38 monoclonal antibodyPrescription onlyDarzalex (daratumumab) is an anti-CD38 monoclonal antibody. It's used to treat multiple myeloma in adults, often in combination with other anticancer medications. Darzalex (daratumumab) is given as an intravenous infusion through your vein (IV). Typically, you receive it every week or every few weeks, depending on where you are in the treatment process. Some common side effects of Darzalex (daratumumab) include infusion-related reactions, higher risk of infection, and feeling tired.
Summary for Anti-CD38 monoclonal antibodyPrescription onlySarclisa (isatuximab or isatuximab-irfc) is a monoclonal antibody that’s used to treat a type of blood cancer called multiple myeloma. It helps stop the cancer from growing and spreading. Sarclisa (isatuximab) is given as an intravenous infusion through your vein (IV). It’s typically given together with two other medications to treat cancer. Sarclisa (isatuximab) might cause side effects such as infusion-related reactions, low white blood cell counts, and diarrhea.
Indications of Darzalex vs. Sarclisa
Indications for•Adults newly diagnosed with multiple myeloma (MM), but not able to receive stem cell transplant (in combination with other anticancer medications)•Adults newly diagnosed with MM and able to receive stem cell transplant (in combination with other anticancer medications)•Adults with advanced MM who already received but didn’t respond well to at least one prior anticancer treatment (in combination with other anticancer medications)•Adults with advanced MM who already received but didn’t respond well to at least three prior anticancer treatments (given alone)Indications for•Multiple myeloma in adults who’ve received at least two previous therapies, given together with Pomalyst (pomalidomide) and dexamethasone•Multiple myeloma in adults who’ve received one to three previous therapies, given together with Kyprolis (carfilzomib) and dexamethasonePros and Cons of Darzalex vs. Sarclisa
Pros and Const for Anti-CD38 monoclonal antibodyPros•Recommended treatment option for people with multiple myeloma•Works in a more specific, targeted way than traditional chemotherapy•Not known to cause hair lossCons•Might cause serious infusion-related reactions•Each infusion lasts several hours long, so not very convenient•Infused into the veinsPros and Const for Anti-CD38 monoclonal antibodyPros•Recommended treatment option for previously-treated multiple myeloma•Works in a more specific, targeted way than traditional chemotherapy•Doesn’t commonly cause typical chemotherapy side effects, such as nausea, vomiting, or hair lossCons•Given as an infusion through the veins, so requires a needle for administration•Might cause serious infusion-related reactions•Might make it more difficult for your body to fight infectionCommon Side Effects of Darzalex vs. Sarclisa
Common Side Effects for•Infusion-related reactions•Decreases in blood cell counts•Cold-like symptoms (upper respiratory infection)•Diarrhea•Constipation•Nerve damage causing tingling, numbness or pain•Tiredness•Swollen hands, ankles, or feet•Nausea•Cough•Fever•Shortness of breath•Feeling weakCommon Side Effects for•Lower red blood cell counts (up to 99%)•Lower white blood cell counts (up to 96%)•Lower platelet counts (up to 94%)•Upper respiratory infection (e.g., sinus infections, bronchitis; up to 67%)•Infusion-related reaction (up to 46%)•Tiredness (42%)•Higher blood pressure (37%)•Pneumonia (up to 36%)•Diarrhea (up to 36%)•Trouble breathing (up to 29%)•Cough (23%)Warnings of Darzalex vs. Sarclisa
Common Side Effects for•Infusion-related reactions•Changes in lab test results for blood transfusions•Lower white blood cell counts (risk of infection)•Lower platelet counts (risk of bleeding)•Changes in test results for treatment responseCommon Side Effects for•Infusion-related reactions•Low white blood cell counts•New cancers•Changes to other lab test results•Harm to unborn babyPrices with our coupons for Darzalex vs. Sarclisa
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