Skip to main content
HomeDrug Comparisons
Drug bottle and Pill

Compare Crinone vs. Prometrium

Head-to-head comparisons of medication uses, side effects, warnings, and more.

  • Crinone (progesterone)
    Progesterone (Prometrium)
  • Crinone (progesterone)
    Progesterone (Prometrium)

  • Summary of Crinone vs. Prometrium

    Summary for Progesterone
    Prescription only

    Crinone (progesterone) is a vaginal gel that's used in fertility treatments. It's also used to help restart menstrual periods. This medication contains progesterone, which is a hormone that's naturally made in the body. You insert Crinone (progesterone) into the vagina using a prefilled applicator. For fertility, it's inserted once or twice a day. And for menstrual periods, the medication is inserted every other day. Some possible side effects include headache, stomach pain, and vaginal discharge.

    Summary for Progesterone
    Prescription only

    Progesterone (Prometrium) is an oral medication used to protect the uterus in postmenopausal women (those who've gone through menopause) who are also taking estrogen. It can also help regulate menstrual cycles in people who aren't getting their period. The medication is typically taken by mouth once at bedtime for 10-12 days, depending on what you're taking it for. Potential side effects include headache, weight gain or weight loss, and breast tenderness.

  • Indications of Crinone vs. Prometrium

    Indications for
    •Infertility
    •Lack of menstrual periods
    Indications for
    •Protection of the uterus for postmenopausal women also taking estrogen medications
    •Lack of menstrual periods due to hormone imbalance

  • Pros and Cons of Crinone vs. Prometrium

    Pros and Const for Progesterone
    Pros
    •Comes with easy-to-use, prefilled applicators
    •Used less often than the alternative progesterone vaginal insert
    •Not as painful as progesterone injections
    Cons
    •Might cause breast growth and breast pain
    •Might be uncomfortable to use for some
    •Can cause messy discharge, so you might need to wear panty liners
    •Not available as a lower-cost generic
    Pros and Const for Progesterone
    Pros
    •Helps protect the uterus and regulate periods
    •Taken by mouth once a day
    •Might be easier to take than the injection form
    Cons
    •Not a good option for people with liver problems
    •Shouldn't be used in people with a peanut allergy
    •Potentially raises your risk of serious blood clots

  • Common Side Effects of Crinone vs. Prometrium

    Common Side Effects for
    •Breast growth (40%)
    •Sleepiness (27%)
    •Constipation (27%)
    •Nausea (22%)
    •Headache (17%)
    •Pain around the vaginal opening (17%)
    •Nervousness (16%)
    •Needing to urinate in the middle of the night (13%)
    •Stomach pain (12%)
    •Depression (11%)
    •Lowered sex drive (10%)
    Common Side Effects for
    •Headache (31%)
    •Breast tenderness (27%)
    •Joint pain (20%)
    •Depression (19%)
    •Dizziness (15%)
    •Stomach bloating (12%)
    •Hot flashes (11%)
    •Trouble urinating (11%)
    •Stomach pain (10%)
    •Vaginal discharge (10%)

  • Warnings of Crinone vs. Prometrium

    Common Side Effects for
    •Blood clots
    •Not FDA-approved for preventing miscarriage
    •Fluid buildup
    •Worsening depression
    •Possible rise in blood sugar levels
    Common Side Effects for
    •Blood clots
    •Breast cancer
    •Dementia
    •Vision problems
    •Dizziness and drowsiness
    •Fluid buildup

  • Prices with our coupons for Crinone vs. Prometrium

    Learn more about Crinone
    Learn more about Progesterone

Browse medications

View All

Research prescriptions and over-the-counter medications from A to Z, compare drug prices, and start saving.