Crinone
(progesterone)
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Summary for Crinone
Crinone (progesterone) is a vaginal gel that's used in fertility treatments. It's also used to help restart menstrual periods. This medication contains progesterone, which is a hormone that's naturally made in the body. You insert Crinone (progesterone) into the vagina using a prefilled applicator. For fertility, it's inserted once or twice a day. And for menstrual periods, the medication is inserted every other day. Some possible side effects include headache, stomach pain, and vaginal discharge.
Indications for Crinone
- Infertility
- Lack of menstrual periods
Pros and Cons for Crinone
Pros
- Comes with easy-to-use, prefilled applicators
- Used less often than the alternative progesterone vaginal insert
- Not as painful as progesterone injections
Cons
- Might cause breast growth and breast pain
- Might be uncomfortable to use for some
- Can cause messy discharge, so you might need to wear panty liners
- Not available as a lower-cost generic
Common Side Effects for Crinone
- Breast growth (40%)
- Sleepiness (27%)
- Constipation (27%)
- Nausea (22%)
- Headache (17%)
- Pain around the vaginal opening (17%)
- Nervousness (16%)
- Needing to urinate in the middle of the night (13%)
- Stomach pain (12%)
- Depression (11%)
- Lowered sex drive (10%)
Warnings for Crinone
- Blood clots
- Not FDA-approved for preventing miscarriage
- Fluid buildup
- Worsening depression
- Possible rise in blood sugar levels
Summary for Progesterone
Progesterone is an injection used to treat people who aren't getting their period or have abnormal bleeding due to hormone imbalance. It belongs to a group of medications called progestins and works by replacing progesterone hormone that's naturally made in the body. The medication is typically injected into the muscle daily for 6-8 days in a row. Potential side effects include pain at the injection site, weight gain or weight loss, and breast tenderness.
Indications for Progesterone
- Lack of menstrual periods due to hormone imbalance
- Abnormal bleeding from the uterus due to hormone imbalance
Pros and Cons for Progesterone
Pros
- Helps to regulate your menstrual period
- Only has to be taken once a day
- Might be a good option for people who can't swallow pills
Cons
- Not safe if you have liver problems
- Not a good option if you're allergic to sesame oil
- Potentially raises your risk of serious blood clots
Common Side Effects for Progesterone
- Pain, swelling, and/or redness at the injection site
- Breakthrough bleeding or spotting
- Changes in menstrual flow
- Changes in weight
- Swelling
- Vaginal discharge
- Breast tenderness
Warnings for Progesterone
- Blood clots
- Vision problems
- Fluid buildup
- Pneumonia
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