Key takeaways
Chlorhexidine (Peridex) and chlorhexidine (Hibiclens) are both antiseptic medications used to kill germs, but they are used for different purposes. Chlorhexidine (Peridex) is a prescription mouthwash used to treat gingivitis, a gum inflammation, by preventing dental plaque. You typically rinse with it twice a day after brushing your teeth. On the other hand, chlorhexidine (Hibiclens) is an over-the-counter skin cleanser used to prevent skin infections, prepare skin for surgery, and for hand washing in healthcare settings. It comes in forms like solutions, gels, and cloths. While both medications can cause allergic reactions, chlorhexidine (Peridex) can stain your teeth and change your taste, whereas chlorhexidine (Hibiclens) might cause skin irritation if used on sensitive areas. Chlorhexidine (Peridex) is available as a lower-cost generic, but you need a prescription, while chlorhexidine (Hibiclens) is available over the counter.
