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Bomyntra vs. Xgeva

Bomyntra (denosumab or denosumab-bnht) is an FDA-approved biosimilar to Xgeva (denosumab). It's a RANKL inhibitor that helps prevent bone complications in people with certain types of cancer. The medication is also used to treat giant cell tumor of bone and high calcium levels caused by cancer. Bomyntra (denosumab) is a prefilled syringe that's injected under the skin by a healthcare professional, usually once a month. Common side effects include nausea, tiredness, and diarrhea.

• Prevention of bone problems in adults with multiple myeloma or certain cancers that have spread to the bones
• Giant cell tumor of bone in adults and certain teens who can't have surgery
• High calcium levels caused by cancer (hypercalcemia of malignancy) in adults after bisphosphonate treatment hasn't worked

Cancer that has spread to the bones:

• Tiredness (45%)
• Low phosphate levels (32%)
• Nausea (31%)

Multiple myeloma:

• Diarrhea (34%)
• Nausea (32%)
• Low red blood cells (22%)
• Back pain (21%)

Giant cell tumor of bone: (all ≥ 10%)

• Joint pain
• Back pain
• Pain in the arms and legs
• Tiredness
• Headache
• Nausea
• Common cold symptoms
• Muscle or bone pain
• Toothache
• Vomiting
• Low phosphate levels
• Constipation
• Diarrhea
• Cough

High calcium due to cancer:

• Nausea (30%)
• Shortness of breath (27%)
• Reduced appetite (24%)
• Headache (24%)
• Swelling (24%)
• Vomiting (24%)
• Low red blood cell count (21%)
• Constipation (21%)
• Diarrhea (21%)

• Serious allergic reactions
• Low calcium levels
• Jaw bone problems (osteonecrosis of the jaw)
• Thigh bone fractures
• High calcium levels after stopping treatment
• Spinal fractures after stopping treatment
• Harm to unborn baby

Xgeva (denosumab) is a RANKL inhibitor used to help prevent serious bone problems caused by cancer. It's also approved to treat giant cell tumor of bone and high calcium levels due to cancer. The medication is given as an injection under the skin by a healthcare professional, typically once a month. Common side effects include nausea, tiredness, and diarrhea. Several biosimilar versions of Xgeva (denosumab) are also available.

• Prevention of bone problems in adults with multiple myeloma or certain cancers that have spread to the bones
• Giant cell tumor of bone in adults and certain teens who can't have surgery
• High calcium levels caused by cancer (hypercalcemia of malignancy) in adults after bisphosphonate treatment hasn't worked

Cancer that has spread to the bones:

• Tiredness (45%)
• Low phosphate levels (32%)
• Nausea (31%)

Multiple myeloma:

• Diarrhea (34%)
• Nausea (32%)
• Low red blood cells (22%)
• Back pain (21%)

Giant cell tumor of bone: (all ≥ 10%)

• Joint pain
• Back pain
• Pain in the arms and legs
• Tiredness
• Headache
• Nausea
• Common cold symptoms
• Muscle or bone pain
• Toothache
• Vomiting
• Low phosphate levels
• Constipation
• Diarrhea
• Cough

High calcium due to cancer:

• Nausea (30%)
• Shortness of breath (27%)
• Reduced appetite (24%)
• Headache (24%)
• Swelling (24%)
• Vomiting (24%)
• Low red blood cell count (21%)
• Constipation (21%)
• Diarrhea (21%)

• Serious allergic reactions
• Low calcium levels
• Jaw bone problems (osteonecrosis of the jaw)
• Thigh bone fractures
• High calcium levels after stopping treatment
• Spinal fractures after stopping treatment
• Harm to unborn baby