Amvuttra vs. Onpattro for Hereditary Transthyretin-Mediated Amyloidosis: Important Differences and Potential Risks.

Amvuttra

(vutrisiran)

Onpattro

(patisiran)

Summary for Amvuttra

Prescription only

Amvuttra (vutrisiran) is a prescription injection used to treat nerve damage (polyneuropathy) in adults with a rare condition called hereditary transthyretin-mediated amyloidosis (hATTR). It's also FDA approved to treat heart muscle problems (cardiomyopathy) in adults with either wild-type transthyretin-mediated amyloidosis (ATTRwt) or hATTR. This medication belongs to a drug class called small interfering ribonucleic acids (siRNAs) and is injected under the skin once every 3 months by a healthcare professional. Some common side effects include joint pain and shortness of breath.

Indications for Amvuttra

Polyneuropathy (nerve damage) from hereditary ATTR amyloidosis (hATTR)
Cardiomyopathy (heart muscle problems) from wild-type transthyretin-mediated amyloidosis (ATTRwt) or hATTR

Pros and Cons for Amvuttra

Pros

Injected once every 3 months
Given under the skin, instead of through the veins
Doesn't require pretreatment medications
Treats both nerve and heart problems from ATTR

Cons

Likely to cause low vitamin A levels
Needs to be given by a healthcare professional
Unknown if safe or works well in children
Maybe not safe during pregnancy

Common Side Effects for Amvuttra

Pain in arms and legs (15%)
Joint pain (11%)
Shortness of breath (7%)
Lower vitamin A levels (7%)

Warnings for Amvuttra

Low vitamin A levels

Summary for Onpattro

Prescription only

Onpattro (patisiran) is a medication used for treating nerve damage (polyneuropathy) due to hereditary transthyretin-mediated amyloidosis (hATTR). It's given as an injection into the veins every 3 weeks by a healthcare provider.

Indications for Onpattro

Polyneuropathy from hereditary transthyretin-mediated amyloidosis (hATTR)

Pros and Cons for Onpattro

Pros

Works well to treat hATTR symptoms
Injected once every 3 weeks

Cons

Needs to be given by a healthcare provider
Brand name only, which can be expensive
Requires you to take several medications 1 hour before the infusion to prevent infusion-related reactions