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Compare Amvuttra vs. Onpattro

Head-to-head comparisons of medication uses, side effects, warnings, and more.

  • Amvuttra (vutrisiran)
    Onpattro (patisiran)
  • Amvuttra (vutrisiran)
    Onpattro (patisiran)

  • Summary of Amvuttra vs. Onpattro

    Summary for Small interfering ribonucleic acid (siRNA)
    Prescription only

    Amvuttra (vutrisiran) is a prescription injection used to treat nerve damage (polyneuropathy) in adults with a rare condition called hereditary transthyretin-mediated amyloidosis (hATTR). It's also FDA approved to treat heart muscle problems (cardiomyopathy) in adults with either wild-type transthyretin-mediated amyloidosis (ATTRwt) or hATTR. This medication belongs to a drug class called small interfering ribonucleic acids (siRNAs) and is injected under the skin once every 3 months by a healthcare professional. Some common side effects include joint pain and shortness of breath.

    Summary for Small interfering ribonucleic acid (siRNA)
    Prescription only

    Onpattro (patisiran) is a medication used for treating nerve damage (polyneuropathy) due to hereditary transthyretin-mediated amyloidosis (hATTR). It's given as an injection into the veins every 3 weeks by a healthcare provider.

  • Indications of Amvuttra vs. Onpattro

    Indications for
    •Polyneuropathy (nerve damage) from hereditary ATTR amyloidosis (hATTR)
    •Cardiomyopathy (heart muscle problems) from wild-type transthyretin-mediated amyloidosis (ATTRwt) or hATTR
    Indications for
    •Polyneuropathy from hereditary transthyretin-mediated amyloidosis (hATTR)

  • Pros and Cons of Amvuttra vs. Onpattro

    Pros and Const for Small interfering ribonucleic acid (siRNA)
    Pros
    •Injected once every 3 months
    •Given under the skin, instead of through the veins
    •Doesn't require pretreatment medications
    •Treats both nerve and heart problems from ATTR
    Cons
    •Likely to cause low vitamin A levels
    •Needs to be given by a healthcare professional
    •Unknown if safe or works well in children
    •Maybe not safe during pregnancy
    Pros and Const for Small interfering ribonucleic acid (siRNA)
    Pros
    •Works well to treat hATTR symptoms
    •Injected once every 3 weeks
    Cons
    •Needs to be given by a healthcare provider
    •Brand name only, which can be expensive
    •Requires you to take several medications 1 hour before the infusion to prevent infusion-related reactions

  • Common Side Effects of Amvuttra vs. Onpattro

    Common Side Effects for
    •Pain in arms and legs (15%)
    •Joint pain (11%)
    •Shortness of breath (7%)
    •Lower vitamin A levels (7%)
    Common Side Effects for
    •Upper respiratory infections (29%)
    •Infusion-related reactions (19%)
    •Indigestion (8%)
    •Shortness of breath (8%)
    •Muscle spasms (8%)
    •Joint pain (7%)
    •Skin redness (7%)
    •Bronchitis (7%)
    •Vertigo or a spinning sensation (5%)

  • Warnings of Amvuttra vs. Onpattro

    Common Side Effects for
    •Low vitamin A levels
    Common Side Effects for
    •Infusion reactions
    •Low vitamin A levels

  • Prices with our coupons for Amvuttra vs. Onpattro

    Learn more about Amvuttra
    Learn more about Onpattro

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