Amvuttra vs. Onpattro for Hereditary Transthyretin-Mediated Amyloidosis: Important Differences and Potential Risks.

Amvuttra

(vutrisiran)

Onpattro

(patisiran)

Summary for Amvuttra

Prescription only

Amvuttra (vutrisiran) is a prescription injection used to treat nerve damage (polyneuropathy) in adults with a rare condition called hereditary transthyretin-mediated amyloidosis (hATTR). It's also FDA approved to treat heart muscle problems (cardiomyopathy) in adults with either wild-type transthyretin-mediated amyloidosis (ATTRwt) or hATTR. This medication belongs to a drug class called small interfering ribonucleic acids (siRNAs) and is injected under the skin once every 3 months by a healthcare professional. Some common side effects include joint pain and shortness of breath.

Indications for Amvuttra

Polyneuropathy (nerve damage) from hereditary ATTR amyloidosis (hATTR)
Cardiomyopathy (heart muscle problems) from wild-type transthyretin-mediated amyloidosis (ATTRwt) or hATTR

Pros and Cons for Amvuttra

Pros

Injected once every 3 months
Given under the skin, instead of through the veins
Doesn't require pretreatment medications
Treats both nerve and heart problems from ATTR

Cons

Likely to cause low vitamin A levels
Needs to be given by a healthcare professional
Unknown if safe or works well in children
Maybe not safe during pregnancy

Common Side Effects for Amvuttra

Pain in arms and legs (15%)
Joint pain (11%)
Shortness of breath (7%)
Lower vitamin A levels (7%)

Warnings for Amvuttra

Low vitamin A levels

Summary for Onpattro

Prescription only

Onpattro (patisiran) is a medication used for treating nerve damage (polyneuropathy) due to hereditary transthyretin-mediated amyloidosis (hATTR). It's given as an injection into the veins every 3 weeks by a healthcare provider.

Indications for Onpattro

Polyneuropathy from hereditary transthyretin-mediated amyloidosis (hATTR)

Pros and Cons for Onpattro

Pros

Works well to treat hATTR symptoms
Injected once every 3 weeks

Cons

Needs to be given by a healthcare provider
Brand name only, which can be expensive
Requires you to take several medications 1 hour before the infusion to prevent infusion-related reactions

Common Side Effects for Onpattro

Upper respiratory infections (29%)
Infusion-related reactions (19%)
Indigestion (8%)
Shortness of breath (8%)
Muscle spasms (8%)
Joint pain (7%)
Skin redness (7%)
Bronchitis (7%)
Vertigo or a spinning sensation (5%)

Warnings for Onpattro

Infusion reactions
Low vitamin A levels

Prices with our coupons for Amvuttra vs. Onpattro

Amvuttra1 carton / 0.5ml prefilled syringe of 25mg/0.5ml

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Onpattro15 vials / 5ml of 10mg/5ml

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Amvuttra vs. Onpattro

Amvuttra

Onpattro

Summary for Amvuttra

Indications for Amvuttra

Pros and Cons for Amvuttra

Pros

Cons

Common Side Effects for Amvuttra

Warnings for Amvuttra

Summary for Onpattro

Indications for Onpattro

Pros and Cons for Onpattro

Pros

Cons

Common Side Effects for Onpattro

Warnings for Onpattro

Prices with our coupons for Amvuttra vs. Onpattro

Browse medications by letter

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Amvuttra

Onpattro

Summary for Amvuttra

Indications for Amvuttra

Pros and Cons for Amvuttra

Pros

Cons

Common Side Effects for Amvuttra

Warnings for Amvuttra

Summary for Onpattro

Indications for Onpattro

Pros and Cons for Onpattro

Pros

Cons

Common Side Effects for Onpattro

Warnings for Onpattro