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ACAM2000 vs. Jynneos

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Summary for ACAM2000

Prescription only

ACAM2000 is a live vaccine that's used to prevent smallpox and mpox. It's FDA approved for certain people who are at high risk of being exposed to these viruses. The vaccine is administered as a single dose using a special method where a healthcare professional makes a few small pricks on your skin. A small blister will form at the spot where it was given, showing that the vaccine is working. Common side effects can include redness or pain at the injection site, headache, and tiredness.

Indications for ACAM2000

Pros and Cons for ACAM2000

Pros

  • Protects against both smallpox and mpox
  • Not a routine vaccine that everyone needs to get
  • Only one dose is needed to complete vaccination

Cons

  • Given as multiple pricks into the skin
  • Risk of serious side effects, including heart and skin problems
  • Requires careful aftercare to prevent the virus from spreading

Common Side Effects for ACAM2000

  • Itching at the injection site (up to 92%)
  • Redness at the injection site (up to 74%)
  • Pain at the injection site (up to 67%)
  • Lymph node pain (up to 57%)
  • Headache (up to 50%)
  • Tiredness (up to 48%)
  • Swelling at the injection site (up to 48%)
  • Muscle pain (up to 46%)
  • Feeling unwell (up to 37%)
  • Feeling hot (up to 32%)

Warnings for ACAM2000

  • Serious health problems
  • Heart problems
  • Eye infections
  • Severe skin reactions
  • Harm to unborn baby
  • Severe allergic reactions
  • Prevent spreading the vaccine virus
  • Delay blood and organ donation

Summary for Jynneos

Prescription only

Jynneos is a vaccine that helps lower your risk of getting smallpox and monkeypox infections. This vaccine is only approved by the FDA for adults 18 years and older who are at high risk for these infections. If you're looking to find this vaccine, use our monkeypox vaccine finder.

Indications for Jynneos

  • Prevention of smallpox and monkeypox in adults

Pros and Cons for Jynneos

Pros

Cons

  • Not studied in children
  • Only available as an injection, which can be painful
  • Must be given by a healthcare provider at an office, clinic, or pharmacy

Common Side Effects for Jynneos

  • Pain at injection site (up to 85%)
  • Redness at injection site (up to 81%)
  • Hard lump at injection site (up to 70%)
  • Swelling at injection site (up to 67%)
  • Itching at injection site (up to 43%)
  • Muscle pain (up to 43%)
  • Headache (up to 35%)
  • Feeling tired (up to 34%)

Warnings for Jynneos

  • Severe allergic reaction
  • Might not prevent monkeypox or smallpox

Prices with our coupons for ACAM2000 vs. Jynneos

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Acam20001 vial / 0.3ml
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Price Card Drug Icon
Jynneos1 vial / 0.5ml
$294.42$354.31
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