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Comirnaty

Pfizer COVID-19 vaccine
Used for COVID-19
Used for COVID-19

Comirnaty (Pfizer COVID-19 vaccine) is an mRNA vaccine that's used to prevent infection from the virus that causes COVID-19. It's FDA approved for people 65 years and older, and for children and adults ages 5 to 64 years old who have at least one risk factor for severe COVID. The vaccine is given as a single booster shot into the muscle by a healthcare professional. Common side effects include pain at the injection site, tiredness, headache, and chills.

Reviewed by:
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Daisy Chau, PharmD
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Connie Zheng, PharmD
Last reviewed on October 24, 2025
BasicsSide effectsPros & consPharmacist tipsFAQsWarningsDosageCostAlternativesLatest newsImagesReferencesPricesMedicare
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What is Comirnaty?

What is Comirnaty used for?

  • Prevention of COVID-19 infection in people 65 years of age and older

  • Prevention of COVID-19 infection in people ages 5 to 64 years old with at least one condition that puts them at high risk of serious problems from illness

How Comirnaty works

Comirnaty is an mRNA vaccine. It contains lab-made mRNA (genetic information). This piece of mRNA teaches your body to make a part of the "spike protein" found on the COVID-19 virus.

Your immune system sees this spike protein as something that doesn't belong in your body. This causes your immune system to make antibodies against the protein. These antibodies tell other immune cells to get rid of the protein from the body.

Afterwards, your immune system remembers what the COVID spike protein looks like. So if you get exposed to COVID, your immune system is ready to fight and protect you from getting very sick.

Are you looking for information on Spikevax (Moderna COVID-19 vaccine) or mNEXSPIKE (Moderna COVID-19 vaccine) instead?
When does Comirnaty start working?
Time passed since treatment started:
HOURS
DAYS
WEEKS
MONTHS
Full effect

Drug Facts

Common BrandsComirnaty
Drug ClassmRNA vaccine
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityPrescription only

More on Comirnaty essentials

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What are the side effects of Comirnaty?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

People 12 years and older:
  • Pain at the injection site (up to 91%)
  • Tiredness (up to 78%)
  • Headache (up to 76%)
  • Chills (up to 50%)
  • Muscle pain (up to 46%)
  • Joint pain (up to 28%)
  • Fever (up to 24%)
  • Swelling at the injection site (up to 12%)
  • Redness at the injection site (up to 10%)
People ages 5 to 11 years old:
  • Pain at the injection site (up to 84%)
  • Tiredness (up to 52%)
  • Headache (up to 38%)
  • Redness at the injection site (up to 26%)
  • Swelling at the injection site (up to 20%)
  • Muscle pain (up to 18%)
  • Chills (up to 13%)
  • Fever (up to 8%)
  • Joint pain (up to 8%)

Other Side Effects

  • Diarrhea
  • Vomiting
  • Nausea
  • Weakness
  • Reduced appetite
  • Excessive sweating
  • Night sweats
  • Swollen lymph nodes
  • Fainting
  • Dizziness
  • Arm pain

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Inflammation or swelling of the heart: chest pain, shortness of breath, a racing heart, fainting, tiredness, vomiting, stomach pain, cool or pale skin
  • Serious allergic reactions: difficulty breathing, swelling of the face and throat, fast heartbeat, rash all over the body, dizziness, weakness
When do Comirnaty possible side effects begin and end?
Time passed since treatment started:
MINUTES
HOURS
DAYS
WEEKS
MONTHS
Pain at injection site
Feeling tired
Headache
Muscle pain
Chills

Source: DailyMed

More on Comirnaty side effects

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What Are the COVID-19 Vaccine Side Effects?

Written by Jennifer Gershman, PharmD, CPh, PACS

The following side effects have also been reported

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • Heart muscle inflammation—unusual weakness or fatigue, shortness of breath, chest pain, fast or irregular heartbeat, dizziness, swelling of the ankles, feet, or hands

Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):

pros-and-cons

Pros and cons of Comirnaty

thumbs-up

Pros

Only need 1 shot to be fully vaccinated

Approved for older adults and certain people 5 years and older

thumbs-down

Cons

Doesn't guarantee that you won't get COVID-19 (but helps lessen severity)

Commonly causes temporary pain at injection site, fever, and tiredness

pharmacist-tips

Pharmacist tips for Comirnaty

pharmacist

  • Comirnaty is injected into your muscle by a healthcare professional at an office, clinic, or pharmacy.

    • Comirnaty can cause mild side effects like pain at the injection site, tiredness, muscle aches, fever, and chills. These are normal signs that your body is building protection and usually go away on their own within a few days.

      • If side effects from Comirnaty get worse after 24 hours or don't go away after a few days, contact a healthcare professional.

        • You can place a clean, cool, wet washcloth on the area where you got Comirnaty to help relieve pain or swelling. Moving your arm around can also help reduce soreness.

          • After getting Comirnaty, ask a healthcare professional which medications are safe to take if you have side effects.

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            faqs

            Frequently asked questions about Comirnaty

            How long does Comirnaty last?
            It’s not exactly known how long protection from Comirnaty lasts. In general, each updated shot helps protect you for at least a few months. It's also known that this protection lessens over time. Keep in mind that even if you've been vaccinated, you could still get COVID, but the vaccine usually makes the illness less severe.
            Is Comirnaty the same as the Pfizer vaccine?
            Yes. Comirnaty is the brand name for the Pfizer COVID-19 vaccine.
            Is Comirnaty approved by the FDA?
            Yes. Comirnaty was first approved by the FDA in August 2021 to prevent COVID-19 in people 16 years and older. It's now approved for people 65 years and older, and for children and adults ages 5 to 64 years old at high risk for severe COVID.
            What's the difference between Comirnaty and Spikevax?
            Comirnaty and Spikevax are both mRNA vaccines that help protect people from severe COVID-19. Comirnaty is made by Pfizer, and Spikevax is by Moderna. Both are approved for people 65 years and older. Comirnaty is also approved for people ages 5 to 64 years old with at least one risk factor for severe COVID. But Spikevax is approved for children as young as 6 months of age with at least one risk factor. Talk to a healthcare professional to learn more about the differences or to compare the vaccines.
            Is it okay to switch from Spikevax to Comirnaty?
            It's typically okay to switch from Spikevax to Comirnaty since you can usually mix and match between the different COVID-19 vaccine brands. But if your child is younger than 5 years old, they will mostl likely receive Spikevax since Comirnaty is only approved for children ages 5 and older. Always check with your healthcare professional to confirm which vaccine and timing are best for you or your child.
            Is Comirnaty for seniors?
            Yes. Comirnaty is FDA approved for seniors (people 65 years and older). The vaccine helps protect older adults from getting seriously ill from COVID-19, which is especially important because this age group is at a higher risk for severe illness and complications. If you’re 65 or older, talk to a healthcare professional about getting Comirnaty to help protect yourself from COVID-19.
            How long do Comirnaty side effects last?
            Typically, side effects from Comirnaty are mild and can last up to a few days after the injection. Injection site reactions like redness, pain, or swelling usually start within minutes after the injection and can last for about 1 to 2 days. Other side effects like muscle pain, tiredness, headache, and fever can also take a few days to go away. If any of these side effects become bothersome or don't get better, let a healthcare professional know.
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            What are the risks and warnings for Comirnaty?

            Comirnaty can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

            risk-warning

            Heart inflammation (swelling)

            • Risk factors: Males between ages 12 to 24

              Although very rare, Comirnaty has been linked to heart inflammation, such as myocarditis (swelling of the heart muscle) and pericarditis (swelling of the tissue lining the outside of the heart).

              From reported data, this risk has been higher in males between 12 and 24 years old. Symptoms have typically shown up in the first week after vaccination. Most people recover within a few days after they get medical help and supportive care.

              Call a healthcare professional right away if you have possible signs of heart inflammation after your Comirnaty shot. Look out for chest pain, shortness of breath, or a racing heart.

              risk-warning

              Possible fainting after vaccination

              Some people have fainted shortly after getting vaccines that are injected into the muscle. Tell the healthcare professional if you've ever fainted after a vaccination. They can keep a close eye on you for about 15 minutes after you get Comirnaty to make sure everything is okay. To prevent getting hurt from fainting, it's best to sit down to get your shot and while the care team is watching you.

              risk-warning

              Lowered response to Comirnaty in people with weakened immune systems

              • Risk factors: Medical conditions that weaken the immune system | Taking medications that lower the activity of the immune system

                Comirnaty might not work as well for people with a weakened immune system. This means they could still get very sick from COVID-19, even after getting the vaccine.

                Before getting vaccinated, tell your care team about your health problems and any medications you take. Some conditions, like human immunodeficiency virus (HIV) and cancer, can weaken the immune system. And some medications, like high-dose steroids and transplant medications, can also make your immune system weaker.

                If you have a weak immune system, keep taking steps to protect yourself from COVID. Talk to a healthcare professional about more ways to prevent getting sick.

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                dosage

                Comirnaty dosage forms

                The average cost for 1 syringe of 0.3ml/dose of Comirnaty is $152.73 with a free GoodRx coupon. This is 30.14% off the average retail price of $218.63.
                syringe
                Syringe
                DosageQuantityPrice as low asPrice per unit
                0.3ml/dose1 syringe$152.73$152.73
                vial
                Vial
                DosageQuantityPrice as low asPrice per unit
                0.3ml/dose1 vial$89.23$89.23

                Typical dosing for Comirnaty

                Comirnaty is injected into the muscle by a healthcare professional.

                The typical dose is 1 injection (0.3 mL) into the muscle for the year.

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                How much does Comirnaty cost?

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                Comirnaty (brand)
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                What are alternatives to Comirnaty?

                There are a number of medications that your doctor can prescribe in place of Comirnaty. Compare a few possible alternatives below.
                Comirnaty
                Used for:

                • Prevention of COVID-19 infection in people 65 years of age and older

                • Prevention of COVID-19 infection in people ages 5 to 64 years old with at least one condition that puts them at high risk of serious problems from illness

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                Novavax COVID-19 vaccine
                Used for:

                • Prevention of COVID-19 infection in people aged 12 years and older

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                Used for:

                • Prevention of COVID-19 infection in people 65 years of age and older

                • Prevention of COVID-19 infection in people between 6 months and 64 years old with at least one condition that puts them at high risk of serious problems from illness

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                What is the latest news about Comirnaty?

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                images

                Comirnaty images

                white - COMIRNATY COVID-19 2025-2026 Formula 30mcg / 0.3mL Vaccine Pre-Filled Syringe Suspension for Injection
                This medicine is White Syringe.white - COMIRNATY COVID-19 2025-2026 Formula 30mcg / 0.3mL Vaccine Pre-Filled Syringe Suspension for Injection
                white - COMIRNATY COVID-19 2025-2026 Formula 30mcg / 0.3mL Vaccine Pre-Filled Syringe Suspension for Injection
                This medicine is White Syringe.white - COMIRNATY COVID-19 2025-2026 Formula 30mcg / 0.3mL Vaccine Pre-Filled Syringe Suspension for Injection

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                References

                Best studies we found

                American Lung Association. (2025). Preventing COVID-19.

                Berg, S. (2023). What doctors wish patients knew now about COVID-19 risk and age. American Medical Association.

                Centers for Disease Control and Prevention. (2025). People with Certain Medical Conditions and COVID-19 Risk Factors.

                View All References (6)

                Immunize.org. (2023). Fainting related to vaccination: What you need to know.

                MedlinePlus. (2024). Myocarditis.

                MedlinePlus. (2024). Pericarditis.

                National Human Genome Research Institute. (2025). Antibody.

                National Human Genome Research Institute. (2021). Understanding COVID-19 mRNA vaccines.

                Pfizer Laboratories Div Pfizer Inc. (2025). COMIRNATY- covid-19 vaccine, mrna injection, suspension [package insert]. DailyMed.

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