Protease inhibitor / CYP3A4 inhibitor / HIV NRTI combinations are used to treat and manage HIV infection. These medications work by blocking the HIV protease and reverse transcriptase enzyme to prevent the virus from making copies of itself, with the CYP3A4 inhibitor helping to boost medication levels in the body. These combinations are typically available in oral form. An example is Symtuza. Discuss with your HIV specialist to see whether these medications are right for you to help control your HIV infection.