Penicillin antibiotic / potassium-competitive acid blocker combinations are used to treat Helicobacter pylori (H. pylori) infection. These combinations work by using a penicillin antibiotic to kill the bacteria causing the infection and a potassium-competitive acid blocker to reduce stomach acid, which helps prevent further irritation to the stomach lining. These medications are typically available in oral form. An example of this combination is Voquezna Dual Pak (amoxicillin / vonoprazan). This combination helps you manage your condition effectively by targeting both the infection and the acid production in your stomach.