Aldosterone-antagonist-thiazide-diuretic combinations are used to treat high blood pressure and managing edema (swelling due to fluid retention) from certain health conditions, such as heart failure. These medications work by combining two types of diuretics: aldosterone antagonists, which block the hormone aldosterone to reduce sodium and water retention, and thiazide diuretics, which help your kidneys remove excess salt and water from your body. These combinations are typically available in oral pill form. Examples include spironolactone/hydrochlorothiazide (Aldactazide). You can take these medications to help manage your condition and improve your quality of life.